TOPICAL APPLICATION OF ELADI TAILA AND GHRITAKUMARI IN PESTICIDE- INDUCED CUTANEOUS TOXICITY

The vast and liberal use of pesticides in agriculture has resulted in occurrence of cutaneous toxicity; produced by the irritating chemical substances, is one of the most noticeable effects of exposure to chemicals, prominently by cutaneous, oral or inhalation routes. Thus arises the need to identify a topical remedy to prevent, reduce or nullify them. Open Randomized Clinical Trial was conducted and selected patients were randomly allotted into two groups, Control and Trial. The control group consisted of 10 patients whereas the trial group was further subdivided into 3 groups of 10 patients each. Thus, the total sample size of the study was 40, calculated on the basis of rate of incidence of the condition. Patients of the Group A did not receive any trial drug but followed symptomatic treatment as and when required. Patients of Group T1 were made to apply Ghritakumari prior to commencement of pesticidal spraying. Patients of Group T2 were not subjected to pre spraying application of Ghritakumari but post spraying Eladi taila was applied after decontamination. Patients of Group T3 were advised to follow both pre and post spraying regimens of groups T1 and T2 and were continued daily upto 2 days after the end of the complete spraying procedure with daily follow up. The primary end point of the present study was achieved and the results were found to be statistically significant

Paediatric lateral humeral condyle fractures managed by k-wire fixation, should the wires be buried or left exposed: a dilemma

Background: Fractures of the lateral condyle of the humerus in children are common injuries. If displaced or unstable they may require surgical reduction and fixation with Kirschner wires (K-wires). These may be passed through the skin and left exposed or buried subcutaneously.Methods: A prospective study was carried out in department of orthopaedics at my college from January 2019 to March 2020.  A total number of 37 subjects were included in the study.Results: Patients were followed for a period of 3 months and results were drawn on basis of union, infection, carrying angle at the elbow, and range of motion (ROM) which was assessed by clinico-radiological means.Conclusions: Buried wire group has shown better union rate than exposed group, wires could be removed under local anaesthesia thereby avoiding any major procedure and also the risk of infection is low making this a better option than the exposed cohort

Impact of oral contraceptives on periodontal health

Background: Oral contraceptives pills (OCPs) are common and a convenient form of contraception. The use of hormonal contraceptives by women has been considered to influence gingival and periodontal disease progression.Aim: This study was conducted to assess the effect of oral contraceptive pills on the periodontal health.Materials and method: A cross-sectional comparative study was conducted among 200 females aged 18 years and above of Jaipur city. The study subjects were divided into two groups i.e. contraceptive users and non-contraceptive users, each group consisted 100 females. Data was collected using Modified WHO Performa (1997). Periodontal status was examined using Com- munity Periodontal Index (CPI) and Loss of Attachment (LOA). Chi-square test and one sample t-test was used for statistical analysis and P value was set (p< 0.05) as significant.Results: Mean CPI score in subjects and non-contraceptive users was 2.34+ 0.81 and 1.16+ 0.89 respectively. Mean LOA score in each group was 0.28+ 0.45 and 0.19+ 0.50 respectively.Conclusion: Oral Contraceptive pills had adverse effects on periodontal health.Keywords: Oral contraceptive, community periodontal index, loss of attachment, periodontal healt

Pair-Interactions of Self-Propelled SiO2-Pt Janus Colloids

Driven by the necessity to achieve a thorough comprehension of the bottom-up fabrication process of functional materials, this experimental study investigates the pair-wise interactions or collisions between chemically active SiO2-Pt Janus Colloids. These collisions are categorized based on the Janus colloids' orientations before and after they make physical contact. In addition to the hydrodynamic interactions, the Janus colloids are also known to affect each other's chemical field, resulting in chemophoretic interactions, which depend on the reactive nature of the metal site. These interactions lead to a noticeable decrease in particle speed and changes in orientation, which depends on the duration of contact, yielding different collision types. Our findings reveal distinct configurations of contact during collisions, whose mechanisms and likelihood is found to be dependent primarily on the chemical interactions. Such estimates of collision and their characterization in dilute suspensions shall have key impact in determining the arrangement and time scales of dynamical structures and assemblies of denser suspensions, and potentially the functional materials of the future.Comment: 15 pages, 11 figures

Does sex matter? The influence of gender on gastrointestinal physiology and drug delivery.

We all respond differently to drugs. Personalised medicine aims to improve efficacy and reduce side effects, and efforts are being made to understand the physiological differences that underlie responses to drugs. Genetics, diet and disease state can be key; however, gender also plays an important role in pharmacokinetics, pharmacodynamics and drug toxicity. Differences in metabolism and clearance of drugs as a consequence of distinct hepatic and renal processes in males and females are now much better understood but little is known about gender differences in the gastrointestinal tract. As the recipient of all orally administered medications, differences at this level can have a major impact on drug delivery and bioavailability; yet these continue to be ignored and insufficiently studied in the context of drug disposition. The aim of this review is to highlight the known gender differences in gut physiology. Clinical case studies are presented, where possible, to illustrate the influence of these differences on drug disposition and gaps in current knowledge are highlighted to encourage further research in this area

Association analysis in chia (Salvia hispanica L.)

The present study was carried out in a set of germplasm accessions for yield related traits in Chia. Results of the correlation coefficient revealed a highly significant and positive effect of the number of primary branches, harvest index and oil content on seed yield per plant on both genotypic and phenotypic levels, while plant height had a positive significant correlation with seed yield only at the genotypic level. Through analysis of path coefficients, the positive and significant direct effect of harvest index on genotypic as well as phenotypic levels was inferred, whilst days to 50% flowering and plant height illustrated positive direct effects on seed yield per plant only at the genotypic level. Moderate direct and positive effects of days to maturity at the genotypic level along with the number of primary branches at the phenotypic level were observed on seed yield per plant. The study revealed that harvesting index, days to 50% flowering and fruiting branches could be used as selection criteria traits, which will be very useful in future breeding programmes to enhance yield in Chia

EXPLORING THE LINK BETWEEN CHRONIC OBSTRUCTIVE PULMONARY DISEASE, BRONCHIAL ASTHMA, AND LIPID PROFILES: A CROSS-SECTIONAL STUDY.

Introduction:  This pilot cross-sectional study intended to explore the relationship between Chronic Obstructive Pulmonary Disease (COPD), Bronchial Asthma, and serum lipid levels (HDL, LDL, Total Cholesterol, Triglycerides) as well as serum urea and creatinine. Conducted at Patna Medical College and Hospital, Patna it involved 21 clinically diagnosed stable COPD and bronchial asthma patients. The study cohort was categorized into Mild, Moderate, and Severe COPD based on GOLD criteria.                           Methods:  Data collection involved detailed medical histories and fasting blood specimens. Serum lipids were assessed via enzymatic colorimetric assays, and LDL, HDL, and total cholesterol levels were calculated. Fasting and postprandial blood sugar levels were measured. Results:  The study revealed associations between COPD severity and lipid profiles. Notably, Total Cholesterol was 177.19 mg/dL, HDL was 41.87 mg/dL, LDL was 109.92 mg/dL, and Triglycerides were 115.58 mg/dL. An increase in airway resistance, detectable with an impulse oscillometer, was observed even with minor airway alterations. The study indicated significant correlations between serum triglycerides, LDL, LDL/HDL ratio, cholesterol/HDL ratio, and elevated airway resistance in individuals with bronchial asthma and COPD. Conclusion:  This pilot study provides initial insights into the interplay between COPD, Bronchial Asthma, and lipid profiles. While lipid findings generally fell within the normal range, elevated LDL levels emphasize the need for monitoring and potential interventions to mitigate cardiovascular risk in COPD patients.  Recommendations:  Healthcare providers should regularly monitor serum lipid levels, urea, and creatinine in COPD and bronchial asthma patients, particularly those with severe COPD, to detect and manage abnormalities early, potentially enhancing patient outcomes. Further research with larger sample sizes is required to validate these findings and develop comprehensive guidelines for the care of COPD and bronchial asthma patients