Variations in suprascapular notch morphology and its clinical importance

Background: Suprascapular notch (SSN) is present towards the medial end of superior border of scapula. The morphometric variations of the SSN have been identified. The suprascapular nerve compression is commonly noted at the site of SSN.Methods: The study was carried out in the department of anatomy, SRMS-IMS medical college, Bareilly and SGRRIM-HS Dehradun. The 120 dried scapulae were randomly selected. The age, sex and race of the scapulae were not known. The scapulae were observed carefully for the different shapes of the suprascapular notch. The various dimensions of suprascapular notch were taken by using a digital vernior caliper.  Results: In the present study six types of SSN were noted based on the description by Rengachary SS. et al.22 Type I (15.83%); type II (41.66%); type III (25.00%); type iv (12.50%); type v (1.67%) and type VI (3.33%). We also classified the SSN based on the description by M. Polguj et al. 2011,28 the frequencies were: type I (MVD>STD), 20%; type II (MVD=STD=MTD), 3.33%; type III (STD >MVD), 55.83%; type IV (bony foramen), 3.33% and type V (Without a discrete notch), 17.5%.Conclusion: The suprascapular neuropathy may occur at the various anatomical locations of its course and has a variety of causes. Our study is important for clinician because the narrow SSN increase the risk of suprascapular entrapment neuropathy. So the knowledge of these variations should be kept in the mind of clinicians in the diagnosis and treatment of suprascapular neuropathies.

Morphological status of assimilated atlas vertebra with occipital bone and its clinical significance

Background: Atlas is the first cervical vertebra. Sometimes there is partial or complete fusion of atlas with basal part of the occipital bone known as assimilation of atlas or atlanto-occipital fusion. It is normally congenital. It may be associated with the constriction of foramen magnum which may compress the spinal cord or brain stem.Methods: The 1000 human dry skulls were selected from the anthropology museum of department of anatomy, GSVM medical college, Kanpur. The age and sex of the skulls were not taken into consideration. The skulls were examined for the bony union between the atlas and skull and other variations in assimilated atlas.Results: Fused atlas with skull was seen in 20 skulls (2.0%). Partial fusion of anterior arch of atlas with the occipital bone was seen in 1 specimen (5%) and in 10% it was found complete fusion. In 10% skulls the posterior arch fused with the occipital bone. Bilateral fusion of transverse process with occipital bone was noted in 2 (10%) specimen. The incomplete foramen transversarium was found in 1 skull (5%) {bilateral} and in 2 skulls (10%), the transverse process was noted without the foramen transversarium {bilateral}.Conclusion: Out of 1000 examined skulls, fusion of atlas with the occipital bone was noted in 20 skulls (2%). The knowledge of incidence of assimilation of atlas and its variations may be helpful for the embryologist, neurosurgeons and orthopedic surgeons.

Functional outcome evaluation of distal humerus fracture fixation

Background: Distal humerus fracture are complex, difficult to reduce and fix, cumbersome post-operative mobilization, and yet functional outcome is doubtful. Though various treatment modalities available for past many decades ranging from conservative management, K wire fixation to plate and screws, but still treatment remains difficult. The objective of the study was to assess functional outcome of operative fixation of distal humerus with locking plate and screws.Methods: Prospective study was done in during November 2015 to June 2016 in Vydehi Institute of Medical Sciences and Research Centre, Bengaluru. Patients with distal humerus fractures who were admitted into hospital for operative treatment after fulfilling inclusion and exclusion criteria were included into study. They were followed up to 6 months post-operatively. Functional outcome evaluation was done with Mayo’s elbow performance score.Results: 30 patients were included into study with full data. We had excellent, good, fair and poor outcome in 17, 8, 3, 2 patients respectively. Except for infection in one, elbow stiffness in two and non-union in two patients, we had no other complications.Conclusions: Management of distal humerus fractures with preoperative evaluation, pre-operative planning, use of locking plate and screws, early mobilization can result in good functional outcome

LeGo-Drive: Language-enhanced Goal-oriented Closed-Loop End-to-End Autonomous Driving

Existing Vision-Language models (VLMs) estimate either long-term trajectory waypoints or a set of control actions as a reactive solution for closed-loop planning based on their rich scene comprehension. However, these estimations are coarse and are subjective to their "world understanding" which may generate sub-optimal decisions due to perception errors. In this paper, we introduce LeGo-Drive, which aims to address this issue by estimating a goal location based on the given language command as an intermediate representation in an end-to-end setting. The estimated goal might fall in a non-desirable region, like on top of a car for a parking-like command, leading to inadequate planning. Hence, we propose to train the architecture in an end-to-end manner, resulting in iterative refinement of both the goal and the trajectory collectively. We validate the effectiveness of our method through comprehensive experiments conducted in diverse simulated environments. We report significant improvements in standard autonomous driving metrics, with a goal reaching Success Rate of 81%. We further showcase the versatility of LeGo-Drive across different driving scenarios and linguistic inputs, underscoring its potential for practical deployment in autonomous vehicles and intelligent transportation systems

Designing multi-period supply chain network considering risk and emission: a multi-objective approach

This research formulates a multi-objective problem (MOP) for supply chain network (SCN) design by incorporating the issues of social relationship, carbon emissions, and supply chain risks such as disruption and opportunism. The proposed MOP includes three conflicting objectives: maximization of total profit, minimization of supply disruption and opportunism risks, and minimization of carbon emission considering a number of supply chain constraints. Furthermore, this research analyses the effect of social relationship levels between different tiers of SCN on the profitability, risk, and emission over the time. In this regard, we focus on responding to the following questions. (1) How does the evolving social relationship affect the objectives of the supply chain (SC)? (2) How do the upstream firms’ relationships affect the relationships of downstream firms, and how these relationships influence the objectives of the SC? (3) How does the supply disruption risk interact with the opportunism risk through supply chain relationships, and how these risks affect the objectives of the SC? (4) How do these three conflicting objectives trade-off? A Pareto-based multi-objective evolutionary algorithm–non-dominated sorting genetic algorithm-II (NSGA-II) has been employed to solve the presented problem. In order to improve the quality of solutions, tuning parameters of the NSGA-II are modulated using Taguchi approach. An illustrative example is presented to manifest the capability of the model and the algorithm. The results obtained evince the robust performance of the proposed MOP

Emerging trends in the recovery of ferrospheres and plerospheres from coal fly ash waste and their emerging applications in environmental cleanup

Coal fly ash (CFA) is a major global problem due to its production in huge volumes. Fly ash has numerous toxic heavy metals; thus, it is considered a hazardous material. However, it also has several value-added minerals like ferrous, alumina, and silica along with other minerals. Fly ash also has several natural micro- to nano-structured materials; for instance, spherical ferrous-rich particles, cenospheres, plerospheres, carbon nanomaterials, and unburned soot. These micron- to nano-sized particles are formed from the molten slag of coal, followed by condensation. Among these particles, plerospheres which are hollow spherical particles, and ferrospheres which are ferrous-rich particles, have potential applications in the environmental cleanup, research, catalytic industries, and glass and ceramics industries. Additionally, these particles could be further surface-functionalized or purified for other applications. Moreover, these particles are widely explored for their potential in the army and other defense systems like lightweight materials and sensing The recovery of such particles from waste fly ash will make the process and remediation technology economically and environmentally friendly. The current review focuses on the various structural and elemental properties of ferrospheres and plerospheres from fly ash. This review also focuses on the emerging applications of both naturally formed materials in CFA

A comprehensive appraisal of mechanism of anti-CRISPR proteins: an advanced genome editor to amend the CRISPR gene editing

The development of precise and controlled CRISPR-Cas tools has been made possible by the discovery of protein inhibitors of CRISPR-Cas systems, called anti-CRISPRs (Acrs). The Acr protein has the ability to control off-targeted mutations and impede Cas protein–editing operations. Acr can help with selective breeding, which could help plants and animals improve their valuable features. In this review, the Acr protein–based inhibitory mechanisms that have been adopted by several Acrs, such as (a) the interruption of CRISPR-Cas complex assembly, (b) interference with target DNA binding, (c) blocking of target DNA/RNA cleavage, and (d) enzymatic modification or degradation of signalling molecules, were discussed. In addition, this review emphasizes the applications of Acr proteins in the plant research

Detection of anti-Mycobacterium avium subspecies paratuberculosis antibodies in thyroid and type-1 diabetes patients

49-52Mycobacterium avium subspecies paratuberculosis (MAP) causes granulomatous intestinal disease in animals (Johne’s diseases). MAP has also been associated with several autoimmune disorders. In this study, we screened serum samples from confirmed patients of thyroid and type 1 diabetes for the presence of antibody against MAP. We used newly developed 'cocktail ELISA' (based on recombinant secretary proteins) and extensively validated 'indigenous ELISA' (based on whole cell protoplasmic antigen) and both the tests were also compared for their diagnostic potential. A total of 90 serums samples were included of which anti-MAP antibodies was detected in 28.8% and 26.6% of samples by indigenous ELISA (iELISA) and cocktail ELISA (cELISA), respectively. There was almost perfect agreement between the two tests in detecting the anti-MAP antibodies. Study raises concern on high detection of anti-MAP antibodies in human, thus warranting necessary control measure to minimize MAP exposure in human beings