1,067 research outputs found
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Fabrication and Characterization of Electrospun Drug-eluting Nanofibers from Polycaprolactone/Chitosan Blends
Electrospinning has emerged as a widely accepted technique with ability to produce nanofibers that can be employed in many biomedical applications. In particular, drug-eluting nanofibers have become very popular in controlled release of small molecule drugs. In this study, nanofibers from blends of polylactocaprone (PCL) and chitosan (CHI) were electrospun with the ability to load a model drug, acetylsalicylic acid (ASA), at 10 wt%. PCL/CHI fibers exhibited smooth surface morphology at polymer compositions ranging from 100/0 to 40/60 with or without the incorporation of ASA. Mechanical properties suggested a brittle failure mechanism for fibers loaded with drug. In vitro drug release study displayed a controlled release profile of ASA up to 48 h. Our study aims to explore the drug-polymer interactions and their effects on fiber structure, mechanical properties and drug release profile.Cockrell School of Engineerin
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Water Content and Thermoplastic Polyurethane Effects on Thrombosis Clotting
One of the main factors that can increase the chance of
heart disease is unwanted blood clotting, or thrombosis. In
addition, implantable biomaterials and/or medical devices are
likely to trigger a series of adverse reactions that can lead to
unwanted blood clotting. Herein, we study a thromboresistant
polymeric material, specifically thermoplastic polyurethanes
(TPUs), on their physical properties and anticoagulation
performance. Their hydrophobic nature and superior
mechanical properties make them an ideal candidate for
coating materials on implantable medical devices, such as
vascular stents. Our results show that hydrophobic TPUs
absorbed minimal to negligible water content and provided
excellent thromboresistant properties against human plasma.Cockrell School of Engineerin
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Prevention Strategies of Traumatic Brain Injury in Football Players
In this project, we study the effects of the impact angle
during a helmet-to-helmet collision on stress distribution and
deacceleration values of the brain tissue in efforts to reduce
brain injuries for football players. The overall goal is to
provide sufficient information to improve the design of helmet
technology. In addition, our study will be able to inform the
athletes to avoid a helmet-to-helmet collision, such that, they
can be trained to shift their heads in the horizontal direction to
create a “glancing blow” effect. It is suggested that by avoiding
a helmet-to-helmet collision, both rotational acceleration and
stress can be reduced leading to a lower probability of
receiving concussions and subsequent brain injuries [1].Cockrell School of Engineerin
Modified Instantaneous Power Control with Phase Compensation and Current-limited Function under Unbalanced Grid Faults
Overview of Power Electronic Converter Topologies Enabling Large-Scale Hydrogen Production via Water Electrolysis
Renewable power-to-hydrogen (P2H) technology is one of the most promising solutions for fulfilling the increasing global demand for hydrogen and to buffer large-scale, fluctuating renewable energies. The high-power, high-current ac/dc converter plays a crucial role in P2H facilities, transforming medium-voltage (MV) ac power to a large dc current to supply hydrogen electrolyzers. This work introduces the general requirements, and overviews several power converter topologies for P2H systems. The performances of different topologies are evaluated and compared from multiple perspectives. Moreover, the future trend of eliminating the line frequency transformer (LFT) is discussed. This work can provide guidance for future designing and implementing of power-electronics-based P2H systems
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