Fabrication and Characterization of Electrospun Drug-eluting Nanofibers from Polycaprolactone/Chitosan Blends

Electrospinning has emerged as a widely accepted technique with ability to produce nanofibers that can be employed in many biomedical applications. In particular, drug-eluting nanofibers have become very popular in controlled release of small molecule drugs. In this study, nanofibers from blends of polylactocaprone (PCL) and chitosan (CHI) were electrospun with the ability to load a model drug, acetylsalicylic acid (ASA), at 10 wt%. PCL/CHI fibers exhibited smooth surface morphology at polymer compositions ranging from 100/0 to 40/60 with or without the incorporation of ASA. Mechanical properties suggested a brittle failure mechanism for fibers loaded with drug. In vitro drug release study displayed a controlled release profile of ASA up to 48 h. Our study aims to explore the drug-polymer interactions and their effects on fiber structure, mechanical properties and drug release profile.Cockrell School of Engineerin

Water Content and Thermoplastic Polyurethane Effects on Thrombosis Clotting

One of the main factors that can increase the chance of heart disease is unwanted blood clotting, or thrombosis. In addition, implantable biomaterials and/or medical devices are likely to trigger a series of adverse reactions that can lead to unwanted blood clotting. Herein, we study a thromboresistant polymeric material, specifically thermoplastic polyurethanes (TPUs), on their physical properties and anticoagulation performance. Their hydrophobic nature and superior mechanical properties make them an ideal candidate for coating materials on implantable medical devices, such as vascular stents. Our results show that hydrophobic TPUs absorbed minimal to negligible water content and provided excellent thromboresistant properties against human plasma.Cockrell School of Engineerin

Prevention Strategies of Traumatic Brain Injury in Football Players

In this project, we study the effects of the impact angle during a helmet-to-helmet collision on stress distribution and deacceleration values of the brain tissue in efforts to reduce brain injuries for football players. The overall goal is to provide sufficient information to improve the design of helmet technology. In addition, our study will be able to inform the athletes to avoid a helmet-to-helmet collision, such that, they can be trained to shift their heads in the horizontal direction to create a “glancing blow” effect. It is suggested that by avoiding a helmet-to-helmet collision, both rotational acceleration and stress can be reduced leading to a lower probability of receiving concussions and subsequent brain injuries [1].Cockrell School of Engineerin

Overview of Power Electronic Converter Topologies Enabling Large-Scale Hydrogen Production via Water Electrolysis

Renewable power-to-hydrogen (P2H) technology is one of the most promising solutions for fulfilling the increasing global demand for hydrogen and to buffer large-scale, fluctuating renewable energies. The high-power, high-current ac/dc converter plays a crucial role in P2H facilities, transforming medium-voltage (MV) ac power to a large dc current to supply hydrogen electrolyzers. This work introduces the general requirements, and overviews several power converter topologies for P2H systems. The performances of different topologies are evaluated and compared from multiple perspectives. Moreover, the future trend of eliminating the line frequency transformer (LFT) is discussed. This work can provide guidance for future designing and implementing of power-electronics-based P2H systems