837 research outputs found

    The effect of school size, socioeconomic status, and grade -level configuration on academic achievement in Louisiana public schools

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    The national emphasis on continually improving education for all students coupled with accountability requires educators and policymakers to identify and implement effective schooling structures and strategies. In this study, the researcher examined the relationship among school size, socioeconomic status of students, the interaction of school size and socioeconomic status (SES), grade-level configuration, and academic achievement in Louisiana. An extensive data set representing 1362 public PK–12 schools was analyzed at the 4th, 8th, and 10th grade levels. The construct of schooling as a production process was used as a theoretical model wherein the education production function was used to describe the relation between school inputs and student outcomes. To determine the impact of input variables on student achievement, thirty-six hypotheses were tested. Ordinary Least Squares (OLS) procedures were used to assess the relationships among variables. Moreover, to determine the differential impact of school size, SES, and the interaction of school size and SES on academic achievement across grade-level configurations, a variant of the F-test known as the “Chow test” was utilized. Further, Multivariate Analysis of Variance (MANOVA) was used to determine the effects of school size, SES, and the interaction of school size and SES on academic achievement. Where significant interaction effects were found, a univariate ANOVA was calculated. Post-hoc tests, namely Tukey\u27s HSD, were then conducted on each of the models. The results of this study indicate that there is a relationship among the variables investigated. The poverty level was found to impact significantly the percentage of students passing the state\u27s high stakes tests across the 4th, 8th, and 10th grade levels. At all grades and across all SES levels within an elementary, middle/junior high, and secondary configuration, the mean percentage of students passing the LEAP 21 increased as enrollment size increased. The level of poverty did not alter the positive impact of school size on academic achievement. The results of this study support the notion that the effectiveness and efficiency of school size may best be represented by a U-shaped curve wherein schools may either be too small or too large to operate at optimal levels

    In praise of the referee

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    There has been a lively debate in many fields, including statistics and related applied fields such as psychology and biomedical research, on possible reforms of the scholarly publishing system. Currently, referees contribute so much to improve scientific papers, both directly through constructive criticism and indirectly through the threat of rejection. We discuss ways in which new approaches to journal publication could continue to make use of the valuable efforts of peer reviewers.Comment: 13 page

    Intrinsic time gravity and the Lichnerowicz-York equation

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    We investigate the effect on the Hamiltonian structure of general relativity of choosing an intrinsic time to fix the time slicing. 3-covariance with momentum constraint is maintained, but the Hamiltonian constraint is replaced by a dynamical equation for the trace of the momentum. This reveals a very simple structure with a local reduced Hamiltonian. The theory is easily generalised; in particular, the square of the Cotton-York tensor density can be added as an extra part of the potential while at the same time maintaining the classic 2 + 2 degrees of freedom. Initial data construction is simple in the extended theory; we get a generalised Lichnerowicz-York equation with nice existence and uniqueness properties. Adding standard matter fields is quite straightforward.Comment: 4 page

    Complex organisation and structure of the ghrelin antisense strand gene GHRLOS, a candidate non-coding RNA gene

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    <p>Abstract</p> <p>Background</p> <p>The peptide hormone ghrelin has many important physiological and pathophysiological roles, including the stimulation of growth hormone (GH) release, appetite regulation, gut motility and proliferation of cancer cells. We previously identified a gene on the opposite strand of the ghrelin gene, ghrelinOS (<it>GHRLOS</it>), which spans the promoter and untranslated regions of the ghrelin gene (<it>GHRL</it>). Here we further characterise <it>GHRLOS</it>.</p> <p>Results</p> <p>We have described <it>GHRLOS </it>mRNA isoforms that extend over 1.4 kb of the promoter region and 106 nucleotides of exon 4 of the ghrelin gene, <it>GHRL</it>. These <it>GHRLOS </it>transcripts initiate 4.8 kb downstream of the terminal exon 4 of <it>GHRL </it>and are present in the 3' untranslated exon of the adjacent gene <it>TATDN2 </it>(TatD DNase domain containing 2). Interestingly, we have also identified a putative non-coding <it>TATDN2-GHRLOS </it>chimaeric transcript, indicating that <it>GHRLOS </it>RNA biogenesis is extremely complex. Moreover, we have discovered that the 3' region of <it>GHRLOS </it>is also antisense, in a tail-to-tail fashion to a novel terminal exon of the neighbouring <it>SEC13 </it>gene, which is important in protein transport. Sequence analyses revealed that <it>GHRLOS </it>is riddled with stop codons, and that there is little nucleotide and amino-acid sequence conservation of the <it>GHRLOS </it>gene between vertebrates. The gene spans 44 kb on 3p25.3, is extensively spliced and harbours multiple variable exons. We have also investigated the expression of <it>GHRLOS </it>and found evidence of differential tissue expression. It is highly expressed in tissues which are emerging as major sites of non-coding RNA expression (the thymus, brain, and testis), as well as in the ovary and uterus. In contrast, very low levels were found in the stomach where sense, <it>GHRL </it>derived RNAs are highly expressed.</p> <p>Conclusion</p> <p><it>GHRLOS </it>RNA transcripts display several distinctive features of non-coding (ncRNA) genes, including 5' capping, polyadenylation, extensive splicing and short open reading frames. The gene is also non-conserved, with differential and tissue-restricted expression. The overlapping genomic arrangement of <it>GHRLOS </it>with the ghrelin gene indicates that it is likely to have interesting regulatory and functional roles in the ghrelin axis.</p

    The proximal first exon architecture of the murine ghrelin gene is highly similar to its human orthologue

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    BACKGROUND: The murine ghrelin gene (Ghrl), originally sequenced from stomach tissue, contains five exons and a single transcription start site in a short, 19 bp first exon (exon 0). We recently isolated several novel first exons of the human ghrelin gene and found evidence of a complex transcriptional repertoire. In this report, we examined the 5' exons of the murine ghrelin orthologue in a range of tissues using 5' RACE. -----FINDINGS: 5' RACE revealed two transcription start sites (TSSs) in exon 0 and four TSSs in intron 0, which correspond to 5' extensions of exon 1. Using quantitative, real-time RT-PCR (qRT-PCR), we demonstrated that extended exon 1 containing Ghrl transcripts are largely confined to the spleen, adrenal gland, stomach, and skin. -----CONCLUSION: We demonstrate that multiple transcription start sites are present in exon 0 and an extended exon 1 of the murine ghrelin gene, similar to the proximal first exon organisation of its human orthologue. The identification of several transcription start sites in intron 0 of mouse ghrelin (resulting in an extension of exon 1) raises the possibility that developmental-, cell- and tissue-specific Ghrl mRNA species are created by employing alternative promoters and further studies of the murine ghrelin gene are warranted

    Parameterized Inapproximability of Target Set Selection and Generalizations

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    In this paper, we consider the Target Set Selection problem: given a graph and a threshold value thr(v)thr(v) for any vertex vv of the graph, find a minimum size vertex-subset to "activate" s.t. all the vertices of the graph are activated at the end of the propagation process. A vertex vv is activated during the propagation process if at least thr(v)thr(v) of its neighbors are activated. This problem models several practical issues like faults in distributed networks or word-to-mouth recommendations in social networks. We show that for any functions ff and ρ\rho this problem cannot be approximated within a factor of ρ(k)\rho(k) in f(k)nO(1)f(k) \cdot n^{O(1)} time, unless FPT = W[P], even for restricted thresholds (namely constant and majority thresholds). We also study the cardinality constraint maximization and minimization versions of the problem for which we prove similar hardness results

    Quantum Gravity and Inflation

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    Using the Ashtekar-Sen variables of loop quantum gravity, a new class of exact solutions to the equations of quantum cosmology is found for gravity coupled to a scalar field, that corresponds to inflating universes. The scalar field, which has an arbitrary potential, is treated as a time variable, reducing the hamiltonian constraint to a time-dependent Schroedinger equation. When reduced to the homogeneous and isotropic case, this is solved exactly by a set of solutions that extend the Kodama state, taking into account the time dependence of the vacuum energy. Each quantum state corresponds to a classical solution of the Hamiltonian-Jacobi equation. The study of the latter shows evidence for an attractor, suggesting a universality in the phenomena of inflation. Finally, wavepackets can be constructed by superposing solutions with different ratios of kinetic to potential scalar field energy, resolving, at least in this case, the issue of normalizability of the Kodama state.Comment: 18 Pages, 2 Figures; major corrections to equations but prior results still hold, updated reference

    Innovative Use of Technology Media to Establish a Common Research Agenda in Educational Leadership

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    This study utilized innovative technologies toestablish a common research agenda among senior and juniorprofessors. The focus is the use of innovative technology-infusedmethodology by (1) individual blogging about leadership at midcenturyto six prompts, (2) collaborative analysis of the six blogprompts and other comments posted at the NCPEA TalkingPoints Blog, and (3) utilizing other media to encourage theresearch habits of these junior professors and advance the studyof educational leadership

    Brst Cohomology and Invariants of 4D Gravity in Ashtekar Variables

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    We discuss the BRST cohomologies of the invariants associated with the description of classical and quantum gravity in four dimensions, using the Ashtekar variables. These invariants are constructed from several BRST cohomology sequences. They provide a systematic and clear characterization of non-local observables in general relativity with unbroken diffeomorphism invariance, and could yield further differential invariants for four-manifolds. The theory includes fluctuations of the vierbein fields, but there exits a non-trivial phase which can be expressed in terms of Witten's topological quantum field theory. In this phase, the descent sequences are degenerate, and the corresponding classical solutions can be identified with the conformally self-dual sector of Einstein manifolds. The full theory includes fluctuations which bring the system out of this sector while preserving diffeomorphism invariance.Comment: 15 page

    Invariant Regularization of Anomaly-Free Chiral Theories

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    We present a generalization of the Frolov-Slavnov invariant regularization scheme for chiral fermion theories in curved spacetimes. local gauge symmetries of the theory, including local Lorentz invariance. The perturbative scheme works for arbitrary representations which satisfy the chiral gauge anomaly and the mixed Lorentz-gauge anomaly cancellation conditions. Anomalous theories on the other hand manifest themselves by having divergent fermion loops which remain unregularized by the scheme. Since the invariant scheme is promoted to also include local Lorentz invariance, spectator fields which do not couple to gravity cannot be, and are not, introduced. Furthermore, the scheme is truly chiral (Weyl) in that all fields, including the regulators, are left-handed; and only the left-handed spin connection is needed. The scheme is, therefore, well suited for the study of the interaction of matter with all four known forces in a completely chiral fashion. In contrast with the vectorlike formulation, the degeneracy between the Adler-Bell-Jackiw current and the fermion number current in the bare action is preserved by the chiral regularization scheme.Comment: 28pgs, LaTeX. Typos corrected. Further remarks on singlet current
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