Self-nano Emulsifying Formulations: An Encouraging Approach for Bioavailability Enhancement and Future Perspective

Currently lipid-based formulations are playing a vital and promising role in improving the oral bioavailability of poorly water-soluble drugs. Lipid based formulations mainly consist of a drug dissolved in lipids such as triglycerides, glycerides, oils and surface active agent. Self nanoemulsifying formulations (SNEF) are isotropic mixtures of lipids/oils, surfactants and co-surfactants. On mild agitation followed by dilution in aqueous media, such as GI fluids, SNEF can form fine oil-in-water (o/w) nanoemulsions. Present chapter summarizes different types of lipid formulations with special emphasis on SNEF, availability of dosage forms, different components with natural surfactants from medicinal plants, mechanism of SNEF, recent advancements in oral drug delivery, solid SNEDDS, patents on SNEF and future prospects. SNEF emerging as powerful technique to improve solubility and commercialization of solid SNEF is the future novel drug delivery to improve bioavailability of poorly water soluble drugs

Role of Drug Repurposing in Cancer Treatment and Liposomal Approach of Drug Targeting

Cancer is the leading cause of death, and incidences are increasing significantly and patients suffering from it desperately need a complete cure from it. The science of using an already-invented drug that has been approved by the FDA for a new application is known as “drug repurposing.” Currently, scientists are drawn to drug repositioning science in order to investigate existing drugs for newer therapeutic uses and cancer treatment. Because of their unique ability to target cancer cells, recently repurposed drugs and the liposomal approach are effective in the treatment of cancer. Liposomes are nanovesicles that are drastically flexible, rapidly penetrate deeper layers of cells, and enhance intracellular uptake. More importantly, liposomes are biocompatible, biodegradable; entrap both hydrophobic and hydrophilic drugs. This chapter summarizes various approaches to drug repurposing, as well as drug repurposing methods, advantages and limitations of drug repurposing, and a liposomal approach to using repurposed drugs in cancer targeting. This chapter also summarizes liposomal structure, drug loading, and the mechanism of liposomes in targeted cancer treatment. The lipid-based liposomal approach is emerging as a powerful technique for improving drug solubility, bioavailability, reducing side effects, and improving the therapeutic efficacy of repurposed drugs for cancer treatment

REVIEW ON ADVANCES IN MANUFACTURING “ 4D PRINTING ”

3D printing, is additionally mentioned as “Additive Manufacturing Process”, move from digital blueprints to physical objects by crating them layer by layer. The 4D printing is predicated on this technology. along one major distinction: It utilizes exceptional materials and refined plans that are "customized" to incite your 3D print to shift its shape. In this way, essentially, 4D printing might be a headway of 3D printing wherein unique materials to print protests that change structure after creation. A trigger could even be water, warmth, wind and different sorts of energy.. 4D printing is also be an extra evolution of 3D printing and is  nearly close to completely alter how we create and produce materials by adding the dimension of transformation over time into the creation process

Review On Advances In Manufacturing “ 4d Printing ”

3D printing, is additionally mentioned as “Additive Manufacturing Process”, move from digital blueprints to physical objects by crating them layer by layer. The 4D printing is predicated on this technology. along one major distinction: It utilizes exceptional materials and refined plans that are "customized" to incite your 3D print to shift its shape. In this way, essentially, 4D printing might be a headway of 3D printing wherein unique materials to print protests that change structure after creation. A trigger could even be water, warmth, wind and different sorts of energy.. 4D printing is also be an extra evolution of 3D printing and is  nearly close to completely alter how we create and produce materials by adding the dimension of transformation over time into the creation process

Role of Leptin in Obesity Management: Current and Herbal Treatment

Obesity is an excessive accumulation of fat in the body associated with numerous complications such as development of hypertension, type 2 diabetes (T2DM), dyslipidemia, sleep apnea, and respiratory disorders; and ultimately life-threatening cardiovascular disease (CVD), stroke, certain types of cancer and osteoarthritis. In 2016, more than 1.9 billion adults aged 18 years and older were overweight. Of these, over 650 million adults were obese, that is over 39% of men and 40% of women were overweight. Rapid rise in obesity cases in both developed and developing countries and people suffering from it needs rapid and complete cure form it without any side effects. Herbal medicine has been used for the treatment of disease for more than 2000 years, and it has proven efficacy. Many studies have confirmed that herbal medicines are effective in the treatment of obesity. Various plants from different families and several phytochemical constituents are responsible for the anti-obesity activity such as fenugreek cinnamon, cardamom, ginger, etc. Present work mainly cover herbal species having leptin-stimulating potential for weight management, importance of leptin, its mechanism of action, current and herbal treatment for effective weight management