Random Forest-Integrated Analysis in AD and LATE Brain Transcriptome-Wide Data to Identify Disease-Specific Gene Expression

Alzheimer\u27s disease (AD) is a complex neurodegenerative disorder that affects thinking, memory, and behavior. Limbic-predominant age-related TDP-43 encephalopathy (LATE) is a recently identified common neurodegenerative disease that mimics the clinical symptoms of AD. The development of drugs to prevent or treat these neurodegenerative diseases has been slow, partly because the genes associated with these diseases are incompletely understood. A notable hindrance from data analysis perspective is that, usually, the clinical samples for patients and controls are highly imbalanced, thus rendering it challenging to apply most existing machine learning algorithms to directly analyze such datasets. Meeting this data analysis challenge is critical, as more specific disease-associated gene identification may enable new insights into underlying disease-driving mechanisms and help find biomarkers and, in turn, improve prospects for effective treatment strategies. In order to detect disease-associated genes based on imbalanced transcriptome-wide data, we proposed an integrated multiple random forests (IMRF) algorithm. IMRF is effective in differentiating putative genes associated with subjects having LATE and/or AD from controls based on transcriptome-wide data, thereby enabling effective discrimination between these samples. Various forms of validations, such as cross-domain verification of our method over other datasets, improved and competitive classification performance by using identified genes, effectiveness of testing data with a classifier that is completely independent from decision trees and random forests, and relationships with prior AD and LATE studies on the genes linked to neurodegeneration, all testify to the effectiveness of IMRF in identifying genes with altered expression in LATE and/or AD. We conclude that IMRF, as an effective feature selection algorithm for imbalanced data, is promising to facilitate the development of new gene biomarkers as well as targets for effective strategies of disease prevention and treatment

Superconductivity and Magnetism in REFeAsO1-xFx (RE=Rare Earth Elements)

Fluoride-doped iron-based oxypnictides containing rare-earth gadolinium (GdFeAsO0.8F0.2) and co-doping with yttrium (Gd0.8Y0.2FeAsO0.8F0.2) have been prepared via conventional solid state reaction at ambient pressure. The non-yttrium substituted oxypnictide show superconducting transition as high as 43.9 K from temperature dependent resistance measurements with the Meissner effect observed at a lower temperature of 40.8 K from temperature dependent magnetization measurements. By replacing a small amount of gadolinium with yttrium Tc was observed to be lowered by 10 K which might be caused by a change in the electronic or magnetic structures since the crystal structure was not altered.Comment: 4 pages, 4 figures, Journal of Physics: Conference Series (Proceedings in the LT25 Low Temperature Physics Conference) Submitte

Top quark chromomagnetic dipole moment in the littlest Higgs model with T-parity

The littlest Higgs model with T-parity, which is called $LHT$ model, predicts the existence of the new particles, such as heavy top quark, heavy gauge bosons, and mirror fermions. We calculate the one-loop contributions of these new particles to the top quark chromomagnetic dipole moment $(CMDM)$ $\Delta K$. We find that the contribution of the $LHT$ model is one order of magnitude smaller than the standard model prediction value.Comment: latex files, 12 pages, 3 figure

Pair production of the T-odd leptons at the LHC

The T-odd leptons predicted by the littlest $Higgs$ model with T-parity can be pair produced via the subprocesses $gg\to \ell^{+}_{H}\ell^{-}_{H}$, $q\bar{q}\to \ell^{+}_{H}\ell^{-}_{H}$, $\gamma\gamma\to \ell^{+}_{H}\ell^{-}_{H}$ and $VV \to \ell^{+}_{H}\ell^{-}_{H}$ ($V$=$W$ or $Z$) at the $CERN$ Large Hadron Collider $(LHC)$. We estimate the hadronic production cross sections for all of these processes and give a simply phenomenology analysis. We find that the cross sections for most of the above processes are very small. However, the value of the cross section for the $Drell-Yan$ process $q\bar{q}\to \ell^{+}_{H}\ell^{-}_{H}$ can reach $270fb$.Comment: 12 pages, 2 figure

Effects of the littlest Higgs model with T-parity on Higgs boson production at high energy e+e−e^{+}e^{-} colliders

The Higgs boson production processes $e^{+}e^{-}\to ZH$, $e^{+}e^{-}\to \bar{\nu_{e}}\nu_{e}H$, and $e^{+}e^{-}\to t\bar{t}H$ are very important for studying Higgs boson properties and further testing new physics beyond the standard model($SM$) in the high energy linear $e^{+}e^{-}$ collider($ILC$). We estimate the contributions of the littlest Higgs model with T-parity($LHT$ model) to these processes and find that the $LHT$ model can generate significantly corrections to the production cross sections of these processes. We expect the possible signals of the $LHT$ model can be detected via these processes in the future $ILC$ experiments.Comment: 9 pages, 2 figures, references adde

Towards End-to-end Video-based Eye-Tracking

Estimating eye-gaze from images alone is a challenging task, in large parts due to un-observable person-specific factors. Achieving high accuracy typically requires labeled data from test users which may not be attainable in real applications. We observe that there exists a strong relationship between what users are looking at and the appearance of the user's eyes. In response to this understanding, we propose a novel dataset and accompanying method which aims to explicitly learn these semantic and temporal relationships. Our video dataset consists of time-synchronized screen recordings, user-facing camera views, and eye gaze data, which allows for new benchmarks in temporal gaze tracking as well as label-free refinement of gaze. Importantly, we demonstrate that the fusion of information from visual stimuli as well as eye images can lead towards achieving performance similar to literature-reported figures acquired through supervised personalization. Our final method yields significant performance improvements on our proposed EVE dataset, with up to a 28 percent improvement in Point-of-Gaze estimates (resulting in 2.49 degrees in angular error), paving the path towards high-accuracy screen-based eye tracking purely from webcam sensors. The dataset and reference source code are available at https://ait.ethz.ch/projects/2020/EVEComment: Accepted at ECCV 202

Oxalate formation under the hyperarid conditions of the Atacama desert as a mineral marker to provide clues to the source of organic carbon on Mars

In this study, we report the detection and characterization of the organic minerals weddellite (CaC2O4 · 2H2O) and whewellite (CaC2O4 · H2O) in the hyperarid, Mars-like conditions of the Salar Grande, Atacama desert, Chile. Weddellite and whewellite are commonly of biological origin on Earth and have great potential for preserving records of carbon geochemistry and possible biological activity on Mars if they are present there. Weddellite and whewellite have been found as secondary minerals occurring inside the lower detrital unit that fills the Salar Grande basin. The extremely low solubility of most oxalate minerals inhibits detection of oxalate by ion chromatography (IC). Crystalline oxalates, including weddellite and whewellite, were detected by X-ray diffraction (XRD). The association of weddellite with surface biota and its presence among subsurface detrital materials suggest the potential of a biological origin for Salar Grande weddellite and whewellite. In this regard, biological activity is uniquely capable of concentrating oxalates at levels detectable by XRD. The complementary detection of oxalate-bearing phases through IC in the upper halite-rich unit suggests the presence of a soluble oxalate phase in the basin that is not detected by XRD. The formation, transport, and concentration of oxalate in the Salar Grande may provide a geochemical analogue for oxalate-bearing minerals recently suggested to exist on Mars

Regulatory T Cells: Potential Target in Anticancer Immunotherapy

SummaryThe concept of regulatory T cells was first described in the early 1970s, and regulatory T cells were called suppressive T cells at that time. Studies that followed have demonstrated that these suppressive T cells negatively regulated tumor immunity and contributed to tumor growth in mice. Despite the importance of these studies, there was extensive skepticism about the existence of these cells, and the concept of suppressive T cells left the center stage of immunologic research for decades. Interleukin-2 receptor α-chain, CD25, was first demonstrated in 1995 to serve as a phenotypic marker for CD4+ regulatory cells. Henceforth, research of regulatory T cells boomed. Regulatory T cells are involved in the pathogenesis of cancer, autoimmune disease, transplantation immunology, and immune tolerance in pregnancy. Recent evidence has demonstrated that regulatory T cellmediated immunosuppression is one of the crucial tumor immune evasion mechanisms and the main obstacle of successful cancer immunotherapy. The mechanism and the potential clinical application of regulatory T cells in cancer immunotherapy are discussed

Charmless hadronic decays B→PP,PV,VVB \to PP, PV, VV and new physics effects in the general two-Higgs doublet models

Based on the low-energy effective Hamiltonian with the generalized factorization, we calculate the new physics contributions to the branching ratios of the two-body charmless hadronic decays of $B_u$ and $B_d$ mesons induced by the new gluonic and electroweak charged-Higgs penguin diagrams in the general two-Higgs doublet models (models I, II and III). Within the considered parameter space, we find that: (a) the new physics effects from new gluonic penguin diagrams strongly dominate over those from the new $\gamma$- and $Z^0$- penguin diagrams; (b) in models I and II, new physics contributions to most studied B meson decay channels are rather small in size: from -15% to 20%; (c) in model III, however, the new physics enhancements to the penguin-dominated decay modes can be significant, $\sim (30 -200)$, and therefore are measurable in forthcoming high precision B experiments; (d) the new physics enhancements to ratios {\cal B}(B \to K \etap) are significant in model III, $\sim (35 -70)$, and hence provide a simple and plausible new physics interpretation for the observed unexpectedly large B \to K \etap decay rates; (e) the theoretical predictions for ${\cal B}(B \to K^+ \pi)$ and ${\cal B}(B \to K^0 \pi^+)$ in model III are still consistent with the data within $2\sigma$ errors; (f) the significant new physics enhancements to the branching ratios of $B \to K^0 \pi^0, K^* \eta, K^{*+} \pi^-, K^+ \phi, K^{*0} \omega, K^{*+} \phi$ and $K^{*0} \phi$ decays are helpful to improve the agreement between the data and the theoretical predictions; (g) the theoretical predictions of ${\cal B}(B \to PP, PV, VV)$ in the 2HDM's are generally consistent with experimental measurements and upper limits ($90$)Comment: 55 pages, Latex file, 17 PS and EPS figures. With minor corrections, final version to be published in Phys.Rev. D. Repot-no: PKU-TH-2000-4

Branching ratios and CP-violating asymmetries of Bs→h1h2B_s \to h_1 h_2 decays in the general two-Higgs doublet models

Based on the low-energy effective Hamiltonian with the generalized factorization, we calculate the new physics contributions to branching ratios and CP-violating asymmetries of the charmless hadronic decays $B_s \to h_1 h_2$ in the standard model and the general two-Higgs doublet models (models I, II, and III). Within the considered paramter space, we find the following. (a) In models I and II, the new physics corrections are always small in size and will be masked by other larger known theoretical uncertainties. (b) In model III, the new physics corrections to the branching ratios of those QCD penguin-dominated decays \ov B_s \to K^0\etapp, K^+ K^{-*}, etc., are large in size and insensitive to the variations of \mhp and \nceff. For tree- or electroweak penguin-dominated decay modes, however, the new physics corrections are very small in size. (c) For \ov B_s \to K^+ K^{-*} and other seven decay modes, the branching ratios are at the level of $(1-3)\times 10^{-5}$ and will be measurable at the future hadron colliders with large $b$ production. (d) Among the studied thirty nine $B_s$ meson decay modes, seven of them can have a CP-violating asymmetry ${\cal A}_{CP}$ larger than 20% in magnitude. The new physics corrections are small or moderate in magnitude. (e) Because of its large and \nceff stable branching ratio and CP violating asymmetry, the decay \ov B_s \to K^+ K^{-*} seems to be the "best" channel to find CP violation of $B_s$ system through studies of two-body charmless decays of $B_s$ meson.Comment: 39 pages, Revtex, 9 eps figures, final version accepted for publication in Phys.Rev.