Specific Heat of Disordered 3^{3}He

Porous aerogel is a source of elastic scattering in superfluid 3He and modifies the properties of the superfluid, suppressing the transition temperature and order parameter. The specific heat jumps for the B-phase of superfluid 3He in aerogel have been measured as a function of pressure and interpreted using the homogeneous and inhomogeneous isotropic scattering models. The specific heat jumps for other p-wave states are estimated for comparison.Comment: Manuscript prepared for LT 2

The benefits of in silico modeling to identify possible small-molecule drugs and their off-target interactions

Accepted for publication in a future issue of Future Medicinal Chemistry.The research into the use of small molecules as drugs continues to be a key driver in the development of molecular databases, computer-aided drug design software and collaborative platforms. The evolution of computational approaches is driven by the essential criteria that a drug molecule has to fulfill, from the affinity to targets to minimal side effects while having adequate absorption, distribution, metabolism, and excretion (ADME) properties. A combination of ligand- and structure-based drug development approaches is already used to obtain consensus predictions of small molecule activities and their off-target interactions. Further integration of these methods into easy-to-use workflows informed by systems biology could realize the full potential of available data in the drug discovery and reduce the attrition of drug candidates.Peer reviewe

Kondo resonance of a Co atom exchange coupled to a ferromagnetic tip

The Kondo effect of a Co atom on Cu(100) was investigated with a low-temperature scanning tunneling microscope using a monoatomically sharp nickel tip. Upon a tip-Co contact, the differential conductance spectra exhibit a spin-split asymmetric Kondo resonance. The computed ab initio value of the exchange coupling is too small to suppress the Kondo effect, but sufficiently large to produce the splitting observed. A quantitative analysis of the line shape using the numerical renormalization group technique indicates that the junction spin polarization is weak.Comment: 5 pages, 4 figure

Signature of high temperature superconductivity in electron doped Sr2IrO4

Sr2IrO4 was predicted to be a high temperature superconductor upon electron doping since it highly resembles the cuprates in crystal structure, electronic structure and magnetic coupling constants. Here we report a scanning tunneling microscopy/spectroscopy (STM/STS) study of Sr2IrO4 with surface electron doping by depositing potassium (K) atoms. At the 0.5-0.7 monolayer (ML) K coverage, we observed a sharp, V-shaped gap with about 95% loss of density of state (DOS) at EFand visible coherence peaks. The gap magnitude is 25-30 meV for 0.5-0.6 ML K coverage and it closes around 50 K. These behaviors exhibit clear signature of superconductivity. Furthermore, we found that with increased electron doping, the system gradually evolves from an insulating state to a normal metallic state, via a pseudogap-like state and possible superconducting state. Our data suggest possible high temperature superconductivity in electron doped Sr2IrO4, and its remarkable analogy to the cuprates.Comment: 11 pages, 5 figure

Measuring Which-Path Information with Coupled Electronic Mach-Zehnder Interferometers

We theoretically investigate a generalized "which-path" measurement on an electronic Mach-Zehnder Interferometer (MZI) implemented via Coulomb coupling to a second electronic MZI acting as a detector. The use of contextual values, or generalized eigenvalues, enables the precise construction of which-path operator averages that are valid for any measurement strength from the available drain currents. The form of the contextual values provides direct physical insight about the measurement being performed, providing information about the correlation strength between system and detector, the measurement inefficiency, and the proper background removal. We find that the detector interferometer must display maximal wave-like behavior to optimally measure the particle-like which-path information in the system interferometer, demonstrating wave-particle complementarity between the system and detector. We also find that the degree of quantum erasure that can be achieved by conditioning on a specific detector drain is directly related to the ambiguity of the measurement. Finally, conditioning the which-path averages on a particular system drain using the zero frequency cross-correlations produces conditioned averages that can become anomalously large due to quantum interference; the weak coupling limit of these conditioned averages can produce both weak values and detector-dependent semi-weak values.Comment: 17 pages, 12 figures, published version including appendi