43 research outputs found
Additions to the known range of Bembidion rufotinctum Chaudoir (Coleoptera: Carabidae: Bembidiini)
Previously known from northeastern United States and Virginia, Bembidion rufotinctum Chaudoir is recorded from North Carolina, Tennessee, South Carolina, and Georgia. Habitat preference for this species appears to remain the same throughout its range. Specimens may be found hiding in cracks in rocks exposed to rapidly flowing water. The presence of this species may be indicated by Pentacora ligata (Say)(Hemiptera: Saldidae) that occurs on the same rocks
Additions to the known range of \u3ci\u3eBembidion rufotinctum \u3c/i\u3eChaudoir (Coleoptera: Carabidae: Bembidiini)
Previously known from northeastern United States and Virginia, Bembidion rufotinctum Chaudoir is recorded from North Carolina, Tennessee, South Carolina, and Georgia. Habitat preference for this species appears to remain the same throughout its range. Specimens may be found hiding in cracks in rocks exposed to rapidly flowing water. The presence of this species may be indicated by Pentacora ligata (Say)(Hemiptera: Saldidae) that occurs on the same rocks
"House of Several Stories" : Preparing and executing stylized realistic acting in a contemporary absurdist play
In the Fall of 2018, we produced Angelo State University's student-directed production of "House of Several Stories" by Jon A. Boulanger. This presentation details how preparing for this production under a student director differed from preparing with a faculty director and the unique process of working with the living playwright using a style of acting that is completely different than an approach rooted in Realism. Additionally, the student director will address what it was like to work hands-on with the playwright, a rare opportunity in the theatre.Ashley Meyer, Mike Burnett, Daniel Anderson, Members of Alpha Psi Omega, and John A Boulange
Dominant de novo DSP mutations cause erythrokeratodermia-cardiomyopathy syndrome
Disorders of keratinization (DOK) show marked genotypic and phenotypic heterogeneity. In most cases, disease is primarily cutaneous, and further clinical evaluation is therefore rarely pursued. We have identified subjects with a novel DOK featuring erythrokeratodermia and initially-asymptomatic, progressive, potentially fatal cardiomyopathy, a finding not previously associated with erythrokeratodermia. We show that de novo missense mutations clustered tightly within a single spectrin repeat of DSP cause this novel cardio-cutaneous disorder, which we term erythrokeratodermia-cardiomyopathy (EKC) syndrome. We demonstrate that DSP mutations in our EKC syndrome subjects affect localization of desmosomal proteins and connexin 43 in the skin, and result in desmosome aggregation, widening of intercellular spaces, and lipid secretory defects. DSP encodes desmoplakin, a primary component of desmosomes, intercellular adhesion junctions most abundant in the epidermis and heart. Though mutations in DSP are known to cause other disorders, our cohort features the unique clinical finding of severe whole-body erythrokeratodermia, with distinct effects on localization of desmosomal proteins and connexin 43. These findings add a severe, previously undescribed syndrome featuring erythrokeratodermia and cardiomyopathy to the spectrum of disease caused by mutation in DSP, and identify a specific region of the protein critical to the pathobiology of EKC syndrome and to DSP function in the heart and skin
The Prevalence and Significance of Staphylococcus aureus
Rationale:
Staphylococcus aureus
is commonly cultured from the sputum of patients with bronchiectasis; however, little is known about the prevalence of the organism in these patients, the characteristics of patients who have grown the organism, or its implications.
Objectives:
Determine the relationship between
S. aureus
and pulmonary function, frequency of exacerbations, and frequency of hospitalization in patients with bronchiectasis
Methods:
The Bronchiectasis Research Registry is a database of adults with non–cystic fibrosis bronchiectasis identified from 13 sites within the United States. Baseline and follow-up demographic, spirometric, microbiologic, and therapeutic data were entered into a central web-based database. Patients were grouped into three cohorts based on their previous respiratory cultures at the time of entry into the Registry:
1
) no prior
S. aureus
or glucose-nonfermenting gram-negative bacilli (NF-GNB) (
Pseudomonas
,
Stenotrophomonas
, or
Burkholderia
spp.);
2
) prior
S. aureus
at least once; or
3
) no prior
S. aureus
but prior NF-GNB at least once. The association between
S. aureus
isolation and pulmonary function and frequency of exacerbations and hospital admissions was assessed, both at baseline and after 1 year of follow-up.
Results:
S. aureus
was cultured from 94 of 830 patients (11.3%) included in the analysis. Patients who had grown
S. aureus
before entry into the Registry had a frequency of prior exacerbations and baseline pulmonary function that was between that of patients who had grown NF-GNB and those who had grown neither NF-GNB or
S. aureus
. Similarly, at the first follow-up visit after study entry, patients who had grown
S. aureus
had a frequency of exacerbations and hospitalizations that was between those of patients who had grown NF-GNB and those who had grown neither NF-GNB nor
S. aureus
. However, in multivariate analysis,
S. aureus
was not associated with pulmonary function, frequency of exacerbation, or hospital admissions. There were no significant differences in patient characteristics or outcomes between patients who had methicillin-sensitive and methicillin-resistant
S. aureus
.
Conclusions:
Staphylococcus aureus
does not appear to be an independent risk factor for severe disease in patients with bronchiectasis enrolled in the Bronchiectasis Research Registry
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The Clinical Features of Bronchiectasis Associated with Alpha-1 Antitrypsin Deficiency, Common Variable Immunodeficiency and Primary Ciliary Dyskinesia--Results from the U.S. Bronchiectasis Research Registry
Objective
: This study compares and contrasts the clinical features of non-cystic fibrosis bronchiectasis with 3 uncommon disorders known to be associated with bronchiectasis but with distinctly different underlying defined pathophysiologic derangements, namely severe alpha-1 antitrypsin deficiency (AATD), common variable immunodeficiency (CVI) and primary ciliary dyskinesia (PCD).
Methods
: The Bronchiectasis Research Registry provides a central database for studying patients with non-cystic fibrosis bronchiectasis. This report consists of information from 13 U.S. sites pertaining to the 3 study diagnoses. Patients with AATD (SZ and ZZ phenotypes only), CVI (patients with IgG≤500), PCD (history of physician diagnosed Kartagener’s syndrome or PCD), and patients with confirmed absence of the above 3 diagnoses (idiopathic control group) were included in the study. Descriptive statistics were computed for the main demographic and clinical characteristics of the sample stratified by group. Values between the groups were compared using Kruskal-Wallis test, and Chi-squared/ Fisher’s exact tests respectively. The significance level was set at 0.05. Software SAS 9.4 was used to perform the statistical analyses.
Results
: Of the 2170 participants in the database enrolled as of January 2017, 615 respondents had sufficient data and were included in the analyses. Patients with PCD (n=79, mean age 41.9 years [standard deviation (SD)=14.5]) were significantly younger than patients with AATD (n=58, mean age 66.9 [SD=10.7]), CVI (n=18, mean age 66.7 years [SD=10.5]) or the idiopathic group (n=460, mean age 64.2 [SD=15.9]),
p
<.0001. Compared to other groups, those with PCD had lower pulmonary function (forced expiratory volume in 1 second [FEV
1
] forced vital capacity [FVC] and FEV1/FVC ratio) (
p
<0.01), and a greater proportion of them reported having exacerbations and/or hospitalizations in the past 2 years (
p
<0.01). Overall,
Pseudomonas aeruginosa
and
Staphylococcus
aureus
were the organisms most commonly isolated from sputum. Mycobacterial infection was most commonly reported in those with AATD.
Conclusions
: This report from the U.S. Bronchiectasis Research Registry compares and contrasts differences in the clinical features of patients suffering from 3 rare conditions, with different underlying causes, to those without. The group with PCD had more symptoms, greater morbidity, lower lung function and more commonly were infected by
Pseudomonas aeruginosa
. A greater percentage of those with AATD reported mycobacterial lung involvement
Airway Clearance Techniques in Bronchiectasis: Analysis From the United States Bronchiectasis and Non-TB Mycobacteria Research Registry
BACKGROUNDIn patients with bronchiectasis, airway clearance techniques (ACTs) are important management strategies. RESEARCH QUESTIONWhat are the differences in patients with bronchiectasis and a productive cough who used ACTs and those who did not? What was the assessment of bronchiectasis exacerbation frequency and change in pulmonary function at 1-year follow up? STUDY DESIGN AND METHODSAdult patients with bronchiectasis and a productive cough in the United States Bronchiectasis and NTM Research Registry were included in the analyses. ACTs included the use of instrumental devices and manual techniques. Stratified analyses of demographic and clinical characteristics were performed by use of ACTs at baseline and follow up. The association between ACT use and clinical outcomes was assessed with the use of unadjusted and adjusted multinomial logistic regression models. RESULTSOf the overall study population (n = 905), 59% used ACTs at baseline. A greater proportion of patients who used ACTs at baseline and follow up continuously had Pseudomonas aeruginosa (47% vs 36%; P = .021) and experienced an exacerbation (81% vs 59%; P < .0001) or hospitalization for pulmonary illness (32% vs 22%; P = .001) in the prior two years, compared with those patients who did not use ACTs. Fifty-eight percent of patients who used ACTs at baseline did not use ACTs at 1-year follow up. There was no significant change in pulmonary function for those who used ACTs at follow up, compared with baseline. Patients who used ACTs at baseline and follow up had greater odds for experiencing exacerbations at follow up compared with those patients who did not use ACTs. INTERPRETATIONIn patients with bronchiectasis and a productive cough, ACTs are used more often if the patients have experienced a prior exacerbation, hospitalization for pulmonary illness, or had P aeruginosa. There is a significant reduction in the use of ACTs at 1-year follow up. The odds of the development of a bronchiectasis exacerbation are higher in those patients who use ACTs continuously, which suggests more frequent use in an ill bronchiectasis population