Labial Reduction Guide for Laminate Veneer Preparation

This article describes a method of fabricating a labial reduction guide for laminate veneer preparations by using a digital tire tread depth gauge and orthodontic wire. The labial reduction guide can help clinicians to achieve accurate reduction of the labial surface. Minimally invasive porcelain laminate veneers have become a popular option in esthetic dentistry. Porcelain laminate veneers require only 25% to 50% of the amount of tooth reduction required for complete coverage restorations.Nevertheless, adequate labial reduction is important in creating optimal esthetics. However, excessive reduction can lead to compromised bond strength due to penetration of the enamel surface. Typically, the appropriate reduction is determined from a diagnostic waxing, and then a silicone index or thermoplastic matrix is made to guide preparation. Verifying the amount of reduction during tooth preparation from the guide can be problematic because the range of labial reduction for laminate veneers is small (0.3 to 0.9 mm). Freehand labial reduction can result in insufficient tooth removal.The purpose of this article was to describe the fabrication and use of a labial reduction guide (LRG) for laminate veneers

Custom Total Occlusal Convergence Angle Sticker Fabrication

This article describes a method of fabricating a custom total occlusal convergence angle sticker with photo editing software and label stickers. The custom total occlusal convergence angle sticker can help clinicians achieve an accurate degree of taper during axial wall reduction of tooth preparation

Mass measurement in boosted decay systems at hadron colliders

We report a new possibility of using the \mct2 (Constransverse mass) variable for mass measurement in single step decay chains involving missing particles with moderate transverse momentum. We show that its experimental feasibility is enhanced compared to the corresponding \mt2-kink method. We apply this method to reconstruct a pair of chargino decay chains.Comment: 6 pages, 12 figures, published in PRD, http://link.aps.org/doi/10.1103/PhysRevD.84.03501

Can Rural Communities Comply with the New Arsenic Standard for Drinking Water?

Our primary concern in this paper is to determine to what extent small communities have difficulty meeting the new stricter 2001 standard for arsenic levels in their drinking water. To do this we survey water users in rural Minnesota communities that had arsenic levels in their water supply exceeding 10 g/L during 2001-2006. Our survey results show that after obtaining complete information concerning the arsenic levels in their drinking water consumers with relatively low levels of arsenic were willing to pay $8-9 annually, while those with high levels of arsenic are willing to pay$15-17 annually. We also found that consumer’s willingness to pay (WTP) didn’t vary by community size. Thus, we conclude that compared to compliance costs ($58-327 per capita annually) small rural communities were likely to find it difficult to cover the cost of compliance through increased water charges. Since many of the communities have to cover these costs of compliance by raising water charges, we ask the basic question: are there better treatment options for these rural communities that will lower the cost to consumers? One option might be to encourage individual householders to use household water treatment devices for communities serving fewer than 500 people. The devices could be made available by the local entity supplying the community’s water possibly at a subsidized rate along with complete information about the arsenic level in the water supply.Community/Rural/Urban Development, Resource /Energy Economics and Policy,

Proteomics Technologies and Challenges

Proteomics is the study of proteins and their interactions in a cell. With the completion of the Human Genome Project, the emphasis is shifting to the protein compliment of the human organism. Because proteome reflects more accurately on the dynamic state of a cell, tissue, or organism, much is expected from proteomics to yield better disease markers for diagnosis and therapy monitoring. The advent of proteomics technologies for global detection and quantitation of proteins creates new opportunities and challenges for those seeking to gain greater understanding of diseases. High-throughput proteomics technologies combining with advanced bioinformatics are extensively used to identify molecular signatures of diseases based on protein pathways and signaling cascades. Mass spectrometry plays a vital role in proteomics and has become an indispensable tool for molecular and cellular biology. While the potential is great, many challenges and issues remain to be solved, such as mining low abundant proteins and integration of proteomics with genomics and metabolomics data. Nevertheless, proteomics is the foundation for constructing and extracting useful knowledge to biomedical research. In this review, a snapshot of contemporary issues in proteomics technologies is discussed

OncomiRs: the discovery and progress of microRNAs in cancers

microRNAs (miRNAs) are evolutionarily conserved, endogenous, small, noncoding RNA molecules of about 22 nucleotides in length that function as posttranscriptional gene regulators. They are deemed to play a crucial role in the initiation and progression of human cancer, and those with a role in cancer are designated as oncogenic miRNAs (oncomiRs). For example, miR-15 and miR-16 induce apoptosis by targeting Bcl2. miRNAs from the miR-17-92 cluster modulate tumor formation and function as oncogenes by influencing the translation of E2F1 mRNA. miR-21 modulates gemcitabine-induced apoptosis by phosphatase and tensin homolog deleted on chromosome 10-dependent activation of PI 3-kinase signaling. miR-34a acts as a suppressor of neuroblastoma tumorigenesis by targeting the mRNA encoding E2F3 and reducing E2F3 protein levels. The chromosomal translocations associating with human tumors disrupt the repression of High mobility group A2 by let-7 miRNA. In addition, the oncomiRs expression profiling of human malignancies has also identified a number of diagnostic and prognostic cancer signatures. This article introduces the roles of oncomiRs in neoplasm development, progression, diagnosis, prognostication, as well as their mechanism of actions on target mRNAs and the functional outcomes of their actions on mRNAs. The paper ends with a brief perspective to the future of oncomiRs