3,252 research outputs found
Gravitational waves from BH-NS binaries: Effective Fisher matrices and parameter estimation using higher harmonics
Inspiralling black hole-neutron star (BH-NS) binaries emit a complicated
gravitational wave signature, produced by multiple harmonics sourced by their
strong local gravitational field and further modulated by the orbital plane's
precession. Some features of this complex signal are easily accessible to
ground-based interferometers (e.g., the rate of change of frequency); others
less so (e.g., the polarization content); and others unavailable (e.g.,
features of the signal out of band). For this reason, an ambiguity function (a
diagnostic of dissimilarity) between two such signals varies on many parameter
scales and ranges. In this paper, we present a method for computing an
approximate, effective Fisher matrix from variations in the ambiguity function
on physically pertinent scales which depend on the relevant signal to noise
ratio. As a concrete example, we explore how higher harmonics improve parameter
measurement accuracy. As previous studies suggest, for our fiducial BH-NS
binaries and for plausible signal amplitudes, we see that higher harmonics at
best marginally improve our ability to measure parameters. For non-precessing
binaries, these Fisher matrices separate into intrinsic (mass, spin) and
extrinsic (geometrical) parameters; higher harmonics principally improve our
knowledge about the line of sight. For the precessing binaries, the extra
information provided by higher harmonics is distributed across several
parameters. We provide concrete estimates for measurement accuracy, using
coordinates adapted to the precession cone in the detector's sensitive band.Comment: 19 pages, 11 figure
Studies of hot photoluminescence in plasmonically-coupled silicon via variable energy excitation and temperature dependent spectroscopy
By coupling silicon nanowires (~150 nm diameter, 20 micron length) with an
{\Omega}-shaped plasmonic nanocavity we are able to generate broadband visible
luminescence, which is induced by high-order hybrid nanocavity-surface plasmon
modes. The nature of this super-bandgap emission is explored via
photoluminescence spectroscopy studies performed with variable laser excitation
energies (1.959 eV to 2.708 eV) and finite difference time domain simulations.
Furthermore, temperature-dependent photoluminescence spectroscopy shows that
the observed emission corresponds to radiative recombination of un-thermalized
(hot) carriers as opposed to a Resonant Raman process
Immune-Checkpoint Inhibitors-Induced Type 1 Diabetes Mellitus: From Its Molecular Mechanisms to Clinical Practice
With the increasing use of immune-checkpoint inhibitors (ICIs), such as anti-cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and anti-programmed cell death-1 (PD-1), for the treatment of malignancies, cases of ICI-induced type 1 diabetes mellitus (ICI-T1DM) have been reported globally. This review focuses on the features and pathogenesis of this disease. T1DM is an immune-related adverse event that occurs following the administration of anti-PD-1 or anti-programmed death ligand-1 (PD-L1) alone or in combination with anti-CTLA-4. More than half of the reported cases presented as abrupt-onset diabetic ketoacidosis. The primary mechanism of ICI-T1DM is T-cell stimulation, which results from the loss of interaction between PD-1 and PD-L1 in pancreatic islet. The similarities and differences between ICI-T1DM and classical T1DM may provide insights into this disease entity. ICI-T1DM is a rare but often life-threatening medical emergency that healthcare professionals and patients need to be aware of. Early detection of and screening for this disease is imperative. At present, the only known treatment for ICI-T1DM is insulin injection. Further research into the mechanisms and risk factors associated with ICI-T1DM development may contribute to a better understanding of this disease entity and the identification of possible preventive strategies
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