2,266 research outputs found
Combination of angiotensin converting enzyme inhibitor and irbesartan for the treatment of heart failure
published_or_final_versio
A Formalism for the Systematic Treatment of Rapidity Logarithms in Quantum Field Theory
Many observables in QCD rely upon the resummation of perturbation theory to
retain predictive power. Resummation follows after one factorizes the cross
section into the rele- vant modes. The class of observables which are sensitive
to soft recoil effects are particularly challenging to factorize and resum
since they involve rapidity logarithms. In this paper we will present a
formalism which allows one to factorize and resum the perturbative series for
such observables in a systematic fashion through the notion of a "rapidity
renormalization group". That is, a Collin-Soper like equation is realized as a
renormalization group equation, but has a more universal applicability to
observables beyond the traditional transverse momentum dependent parton
distribution functions (TMDPDFs) and the Sudakov form factor. This formalism
has the feature that it allows one to track the (non-standard) scheme
dependence which is inherent in any scenario where one performs a resummation
of rapidity divergences. We present a pedagogical introduction to the formalism
by applying it to the well-known massive Sudakov form factor. The formalism is
then used to study observables of current interest. A factorization theorem for
the transverse momentum distribution of Higgs production is presented along
with the result for the resummed cross section at NLL. Our formalism allows one
to define gauge invariant TMDPDFs which are independent of both the hard
scattering amplitude and the soft function, i.e. they are uni- versal. We
present details of the factorization and resummation of the jet broadening
cross section including a renormalization in pT space. We furthermore show how
to regulate and renormalize exclusive processes which are plagued by endpoint
singularities in such a way as to allow for a consistent resummation.Comment: Typos in Appendix C corrected, as well as a typo in eq. 5.6
State-of-the-Art Duolingo Features and Applications
Duolingo is a rapidly growing on-line platform for language learning. In this paper learning theories that are embodied in its design are analyzed and certain shortcomings are identified. In the past two years, Duolingo has expanded its platform with the addition of new applications and features. State-of-the-art updates are reviewed in order to uncover whether they address limitations of Duolingo’s original design or provide enhancements to the learning platform
Circadian Rhythms in Visual Responsiveness in the Behaviorally Arrhythmic Drosophila Clock Mutant ClkJrk
An organism's biological day is characterized by a pattern of anticipatory physiological and behavioral changes that are governed by circadian clocks to align with the 24-h cycling environment. Here, we used flash electroretinograms (ERGs) and steady-state visually evoked potentials (SSVEPs) to examine how visual responsiveness in wild-type Drosophila melanogaster and the circadian clock mutant ClkJrk varies over circadian time. We show that the ERG parameters of wild-type flies vary over the circadian day, with a higher luminance response during the subjective night. The SSVEP response that assesses contrast sensitivity also showed a time-of-day dependence, including 2 prominent peaks within a 24-h period and a maximal response at the end of the subjective day, indicating a tradeoff between luminance and contrast sensitivity. Moreover, the behaviorally arrhythmic ClkJrk mutants maintained a circadian profile in both luminance and contrast sensitivity, but unlike the wild-types, which show bimodal profiles in their visual response, ClkJrk flies show a weakening of the bimodal character, with visual responsiveness tending to peak once a day. We conclude that the ClkJrk mutation mainly affects 1 of 2 functionally coupled oscillators and that the visual system is partially separated from the locomotor circadian circuits that drive bouts of morning and evening activity. As light exposure is a major mechanism for entrainment, our work suggests that a detailed temporal analysis of electrophysiological responses is warranted to better identify the time window at which circadian rhythms are most receptive to light-induced phase shifting
Preventing type 2 diabetes mellitus in Qatar by reducing obesity, smoking, and physical inactivity: mathematical modeling analyses.
BACKGROUND: The aim of this study was to estimate the impact of reducing the prevalence of obesity, smoking, and physical inactivity, and introducing physical activity as an explicit intervention, on the burden of type 2 diabetes mellitus (T2DM), using Qatar as an example. METHODS: A population-level mathematical model was adapted and expanded. The model was stratified by sex, age group, risk factor status, T2DM status, and intervention status, and parameterized by nationally representative data. Modeled interventions were introduced in 2016, reached targeted level by 2031, and then maintained up to 2050. Diverse intervention scenarios were assessed and compared with a counter-factual no intervention baseline scenario. RESULTS: T2DM prevalence increased from 16.7% in 2016 to 24.0% in 2050 in the baseline scenario. By 2050, through halting the rise or reducing obesity prevalence by 10-50%, T2DM prevalence was reduced by 7.8-33.7%, incidence by 8.4-38.9%, and related deaths by 2.1-13.2%. For smoking, through halting the rise or reducing smoking prevalence by 10-50%, T2DM prevalence was reduced by 0.5-2.8%, incidence by 0.5-3.2%, and related deaths by 0.1-0.7%. For physical inactivity, through halting the rise or reducing physical inactivity prevalence by 10-50%, T2DM prevalence was reduced by 0.5-6.9%, incidence by 0.5-7.9%, and related deaths by 0.2-2.8%. Introduction of physical activity with varying intensity at 25% coverage reduced T2DM prevalence by 3.3-9.2%, incidence by 4.2-11.5%, and related deaths by 1.9-5.2%. CONCLUSIONS: Major reductions in T2DM incidence could be accomplished by reducing obesity, while modest reductions could be accomplished by reducing smoking and physical inactivity, or by introducing physical activity as an intervention
Factorization and NNLL Resummation for Higgs Production with a Jet Veto
Using methods of effective field theory, we derive the first all-order
factorization theorem for the Higgs-boson production cross section with a jet
veto, imposed by means of a standard sequential recombination jet algorithm.
Like in the case of small-q_T resummation in Drell-Yan and Higgs production,
the factorization is affected by a collinear anomaly. Our analysis provides the
basis for a systematic resummation of large logarithms log(m_H/p_T^veto) beyond
leading-logarithmic order. Specifically, we present predictions for the
resummed jet-veto cross section and efficiency at next-to-next-to-leading
logarithmic order. Our results have important implications for Higgs-boson
searches at the LHC, where a jet veto is required to suppress background
events.Comment: 28 pages, 5 figures; v2: published version; note added in proo
Cavitation in high-capacity tensiometers:effect of water reservoir surface roughness
High-capacity tensiometers (HCTs) are sensors made to measure negative pore water pressure (suction) directly. In this paper, a new approach is proposed to expand the range and duration of suction measurements for a newly designed HCT. A new technique is employed to reduce significantly the roughness of the diaphragm’s surface on the water reservoir side in order to minimise the possibility of gas nuclei development and the subsequent early cavitation at the water–diaphragm interface. The procedures employed for the design, fabrication, saturation and calibration of the new tensiometers are explained in detail. Furthermore, the performance of the developed HCTs is examined based on a series of experiments carried out on a number of unsaturated clay specimens. An improvement in maximum sustainable suction in the range of 120–150% of their nominal capacity was obtained from different surface treatment methods. Moreover, the results show an improvement of up to 177% for the long-term stability of measurements, compared to the developed ordinary HCTs with untreated diaphragms
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