1 research outputs found
Palladium-Catalyzed Regioselective CâH Bond Arylations of Benzoxazoles and Benzothiazoles at the C7 Position
We
report herein, a very simple catalytic system for the direct
arylation of benzoxazole and benzothiazole derivatives at C7 position,
namely, phosphine-free PdCl<sub>2</sub> associated with PivOK in NMP
at 150 °C. (Thio)Âphenoxy chelation-assisted Pd-catalyzed CâH
bond cleavage, from an opened intermediate, was proposed to explain
this unique regioselectivity. This reaction allows the synthesis of
2-amino-6-arylphenols through the ring opening of the benzoxazole