3,555 research outputs found

    PSS21 Assessing Pruritus Among Patients with Atopic Dermatitis: Targeted Literature and Instrument Review

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    Unimodular Loop Quantum Cosmology

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    Unimodular gravity is based on a modification of the usual Einstein-Hilbert action that allows one to recover general relativity with a dynamical cosmological constant. It also has the interesting property of providing, as the momentum conjugate to the cosmological constant, an emergent clock variable. In this paper we investigate the cosmological reduction of unimodular gravity, and its quantization within the framework of flat homogeneous and isotropic loop quantum cosmology. It is shown that the unimodular clock can be used to construct the physical state space, and that the fundamental features of the previous models featuring scalar field clocks are reproduced. In particular, the classical singularity is replaced by a quantum bounce, which takes place in the same condition as obtained previously. We also find that requirement of semi-classicality demands the expectation value of the cosmological constant to be small (in Planck units). The relation to spin foam models is also studied, and we show that the use of the unimodular time variable leads to a unique vertex expansion.Comment: 26 pages. Revised version taking into account referee's comment

    Numerical simulation of time delay interferometry for eLISA/NGO

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    eLISA/NGO is a new gravitational wave detection proposal with arm length of 10^6 km and one interferometer down-scaled from LISA. Just like LISA and ASTROD-GW, in order to attain the requisite sensitivity for eLISA/NGO, laser frequency noise must be suppressed to below the secondary noises such as the optical path noise, acceleration noise etc. In previous papers, we have performed the numerical simulation of the time delay interferometry (TDI) for LISA and ASTROD-GW with one arm dysfunctional by using the CGC 2.7 ephemeris. The results are well below their respective limits which the laser frequency noise is required to be suppressed. In this paper, we follow the same procedure to simulate the time delay interferometry numerically. To do this, we work out a set of 1000-day optimized mission orbits of the eLISA/NGO spacecraft starting at January 1st, 2021 using the CGC 2.7 ephemeris framework. We then use the numerical method to calculate the residual optical path differences in the second-generation TDI solutions as in our previous papers. The maximum path length difference, for all configurations calculated, is below 13 mm (43 ps). It is well below the limit which the laser frequency noise is required to be suppressed for eLISA/NGO. We compare and discuss the resulting differences due to the different arm lengths for various mission proposals -- eLISA/NGO, an NGO-LISA-type mission with a nominal arm length of 2 x 10^6 km, LISA and ASTROD-GW.Comment: 17 pages, 13 figures, 3 tables, minor changes in description to match the accepted version of Classical and Quantum Gravity. arXiv admin note: text overlap with arXiv:1102.496

    Apical membrane rupture and backward bile flooding in acetaminophen-induced hepatocyte necrosis

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    Morphological changes of hepatocyte death have so far only been described on cells in culture or in tissue sections. Using a high-resolution and high-magnification multiphoton microscopic system, we recorded in living mice serial changes of acetaminophen (APAP)-induced hepatocyte necrosis in relevance to metabolism of a fluorogenic bile solute. Initial changes of hepatocyte injury included basal membrane disruption and loss of mitochondrial membrane potential. An overwhelming event of rupture at adjacent apical membrane resulting in flooding of bile into these hepatocytes might ensue. Belbs formed on basal membrane and then dislodged into the sinusoid circulation. Transmission electron microscopy disclosed a necrotic hepatocyte depicting well the changes after apical membrane rupture and bile flooding. Administration of the antidote N-acetylcysteine dramatically reduced the occurrence of apical membrane rupture. The present results demonstrated a hidden but critical step of apical membrane rupture leading to irreversible APAP-induced hepatocyte injury

    Backpropagation neural network as earthquake early warning tool using a new modified elementary Levenberg–Marquardt Algorithm to minimise backpropagation errors

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    A new modified elementary Levenberg–Marquardt Algorithm (M-LMA) was used to minimise backpropagation errors in training a backpropagation neural network (BPNN) to predict the records related to the Chi-Chi earthquake from four seismic stations: Station-TAP003, Station-TAP005, Station-TCU084, and Station-TCU078 belonging to the Free Field Strong Earthquake Observation Network, with the learning rates of 0.3, 0.05, 0.2, and 0.28, respectively. For these four recording stations, the M-LMA has been shown to produce smaller predicted errors compared to the Levenberg–Marquardt Algorithm (LMA). A sudden predicted error could be an indicator for Early Earthquake Warning (EEW), which indicated the initiation of strong motion due to large earthquakes. A trade-Off decision-making process with BPNN (TDPB), using two alarms, adjusted the threshold of the magnitude of predicted error without a mistaken alarm. With this approach, it is unnecessary to consider the problems of characterising the wave phases and pre-processing, and does not require complex hardware; an existing seismic monitoring network-covered research area was already sufficient for these purposes.</p

    Nitrogen-Functionalized Graphene Nanoflakes (GNFs:N): Tunable Photoluminescence and Electronic Structures

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    This study investigates the strong photoluminescence (PL) and X-ray excited optical luminescence observed in nitrogen-functionalized 2D graphene nanoflakes (GNFs:N), which arise from the significantly enhanced density of states in the region of {\pi} states and the gap between {\pi} and {\pi}* states. The increase in the number of the sp2 clusters in the form of pyridine-like N-C, graphite-N-like, and the C=O bonding and the resonant energy transfer from the N and O atoms to the sp2 clusters were found to be responsible for the blue shift and the enhancement of the main PL emission feature. The enhanced PL is strongly related to the induced changes of the electronic structures and bonding properties, which were revealed by the X-ray absorption near-edge structure, X-ray emission spectroscopy, and resonance inelastic X-ray scattering. The study demonstrates that PL emission can be tailored through appropriate tuning of the nitrogen and oxygen contents in GNFs and pave the way for new optoelectronic devices.Comment: 8 pages, 6 figures (including toc figure

    Orbit optimization for ASTROD-GW and its time delay interferometry with two arms using CGC ephemeris

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    ASTROD-GW (ASTROD [Astrodynamical Space Test of Relativity using Optical Devices] optimized for Gravitation Wave detection) is an optimization of ASTROD to focus on the goal of detection of gravitation waves. The detection sensitivity is shifted 52 times toward larger wavelength compared to that of LISA. The mission orbits of the 3 spacecraft forming a nearly equilateral triangular array are chosen to be near the Sun-Earth Lagrange points L3, L4 and L5. The 3 spacecraft range interferometrically with one another with arm length about 260 million kilometers. In order to attain the requisite sensitivity for ASTROD-GW, laser frequency noise must be suppressed below the secondary noises such as the optical path noise, acceleration noise etc. For suppressing laser frequency noise, we need to use time delay interferometry (TDI) to match the two different optical paths (times of travel). Since planets and other solar-system bodies perturb the orbits of ASTROD-GW spacecraft and affect the (TDI), we simulate the time delay numerically using CGC 2.7 ephemeris framework. To conform to the ASTROD-GW planning, we work out a set of 20-year optimized mission orbits of ASTROD-GW spacecraft starting at June 21, 2028, and calculate the residual optical path differences in the first and second generation TDI for one-detector case. In our optimized mission orbits for 20 years, changes of arm length are less than 0.0003 AU; the relative Doppler velocities are less than 3m/s. All the second generation TDI for one-detector case satisfies the ASTROD-GW requirement.Comment: 17 pages, 7 figures, 1 tabl
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