Long-Term and Seasonal Trends in Estuarine and Coastal Carbonate Systems

Coastal pH and total alkalinity are regulated by a diverse range of local processes superimposed on global trends of warming and ocean acidification, yet few studies have investigated the relative importance of different processes for coastal acidification. We describe long-term (1972-2016) and seasonal trends in the carbonate system of three Danish coastal systems demonstrating that hydrological modification, changes in nutrient inputs from land, and presence/absence of calcifiers can drastically alter carbonate chemistry. Total alkalinity was mainly governed by conservative mixing of freshwater (0.73-5.17mmolkg(-1)) with outer boundary concentrations (similar to 2-2.4mmolkg(-1)), modulated seasonally and spatially (similar to 0.1-0.2mmolkg(-1)) by calcifiers. Nitrate assimilation by primary production, denitrification, and sulfate reduction increased total alkalinity by almost 0.6mmolkg(-1) in the most eutrophic system during a period without calcifiers. Trends in pH ranged from -0.0088year(-1) to 0.021year(-1), the more extreme of these mainly driven by salinity changes in a sluice-controlled lagoon. Temperature increased 0.05 degrees Cyr(-1) across all three systems, which directly accounted for a pH decrease of 0.0008year(-1). Accounting for mixing, salinity, and temperature effects on dissociation and solubility constants, the resulting pH decline (0.0040year(-1)) was about twice the ocean trend, emphasizing the effect of nutrient management on primary production and coastal acidification. Coastal pCO(2) increased similar to 4 times more rapidly than ocean rates, enhancing CO2 emissions to the atmosphere. Indeed, coastal systems undergo more drastic changes than the ocean and coastal acidification trends are substantially enhanced from nutrient reductions to address coastal eutrophication.Peer reviewe

The Threat of Plant Toxins and Bioterrorism: A Review

The intentional use of highly pathogenic microorganisms, such as bacteria, viruses or their toxins, to spread mass-scale diseases that destabilize populations (with motivations of religious or ideological belief, monetary implications, or political decisions) is defined as bioterrorism. Although the success of a bioterrorism attack is not very realistic due to technical constraints, it is not unlikely and the threat of such an attack is higher than ever before. It is now a fact that the capability to create panic has allured terrorists for the use of biological agents (BAs) to cause terror attacks. In the era of biotechnology and nanotechnology, accessibility in terms of price and availability has spread fast, with new sophisticated BAs often being produced and used. Moreover, there are some BAs that are becoming increasingly important, such as toxins produced by bacteria (e.g., Botulinum toxin, BTX), or Enterotoxyn type B, also known as Staphylococcal Enterotoxin B (SEB)) and extractions from plants. The most increasing records are with regards to the extraction / production of ricin, abrin, modeccin, viscumin and volkensin, which are the most lethal plant toxins known to humans, even in low amounts. Moreover, ricin was also developed as an aerosol biological warfare agent (BWA) by the US and its allies during World War II, but was never used. Nowadays, there are increasing records that show how easy it can be to extract plant toxins and transform them into biological weapon agents (BWAs), regardless of the scale of the group of individuals

Respicelltm: An innovative dissolution apparatus for inhaled products

To overcome some of the shortfalls of the types of dissolution testing currently used for pulmonary products, a new custom-built dissolution apparatus has been developed. For inhalation products, the main in vitro characterisation required by pharmacopoeias is the deposition of the active pharmaceutical ingredient in an impactor to estimate the dose delivered to the target site, i.e., the lung. Hence, the collection of the respirable dose (<5 µm) also appears to be an essential requirement for the study of the dissolution rate of particles, because it results as being a relevant parameter for the pharmacological action of the powder. In this sense, dissolution studies could become a complementary test to the routine testing of inhaled formulation delivered dose and aerodynamic performance, providing a set of data significant for product quality, efficacy and/or equivalence. In order to achieve the above-mentioned objectives, an innovative dissolution apparatus (RespiCell™) suitable for the dissolution of the respirable fraction of API deposited on the filter of a fast screening impactor (FSI) (but also of the entire formulation if desirable) was designed at the University of Parma and tested. The purpose of the present work was to use the RespiCell dissolution apparatus to compare and discriminate the dissolution behaviour after aerosolisation of various APIs characterised by different physico-chemical properties (hydrophilic/lipophilic) and formulation strategies (excipients, mixing technology)

Hybrid manufacturing of steel construction parts via arc welding of LPBF-produced and hot-rolled stainless steels

The demand for free-form steel structures having improved performances, reducing labour and resource usage is increasing in the construction sector. Structural nodes are some of the most critical regions for steel structures characterised often by large dimensions. These nodes can exploit the geometrical freedom of metal additive manufacturing (MAM) processes. Laser powder bed fusion (LPBF) is arguably the most developed MAM process, which has limitations regarding the size of the parts to be produced. A way to overcome the size limits of LPBF for producing structural nodes while still exploiting its geometrical capacity is producing hybrid components by welding them to traditionally manufactured beams. Such hybrid joints would constitute a complex system from a mechanical design perspective requiring a systematic analysis in order to be certified for structural use. Accordingly, this work studies the mechanical behaviour of hybrid steel components generated by welding LPBF plates and quarto plates made of AISI 316L stainless steel. The work was guided by a case study based on a large steel node, which helped defining the requirements to fill the gap of the international standards. The mechanical characterisation of LPBF-produced plates and quarto plates, as well as the welded hybrid components revealed a maximum of 10% difference between the properties of the differently manufactured plates. Through the digital image correlation (DIC) analyses, the anisotropic deformation behaviour along the LPBF, weld seam, and quarto plate regions have been identified, and the properties after welding did not show relevant modifications. The tests allowed to define that the failure behaviour is mainly governed by interlayer bounds, and a 0.9 safety reduction parameter for considering the reduction of ductility induced by arc welding to LPBF. Finally, design and production suggestions have been provided for a correct evaluation of gross and effective sections of the designed nodes

Effects of ionizing radiation on flora ten years after the Fukushima Dai-ichi disaster

: The aim of this work is to analyze the effects of ionizing radiation and radionuclides (like 137Cs) in several higher plants located around the Fukushima Dai-ichi Nuclear Power Plant (FNPP), evaluating both their adaptive processes and evolution. After the FNPP accident in March 2011 much attention was focused to the biological consequences of ionizing radiation and radionuclides released in the area surrounding the nuclear plant. This unexpected mishap led to the emission of radionuclides in aerosol and gaseous forms from the power plant, which contaminated a large area, including wild forest, cities, farmlands, mountains, and the sea, causing serious problems. Large quantities of 131I, 137Cs, and 134Cs were detected in the fallout. People were evacuated but the flora continued to be affected by the radiation exposure and by the radioactive dusts' fallout. The response of biota to FNPP irradiation was a complex interaction among radiation dose, dose rate, temporal and spatial variation, varying radiation sensitivities of the different plants' species, and indirect effects from other events. The repeated ionizing radiations, acute or chronic, guarantee an adaptation of the plant species, demonstrating a radio-resistance. Consequently, ionizing radiation affects the genetic structure, especially during chronic irradiation, reducing genetic variability. This reduction is associated with the different susceptibility of plant species to chronic stress. This would confirm the adaptive theory associated with this phenomenon. The effects that ionizing radiation has on different life forms are examined in this review using the FNPP disaster as a case study focusing the attention ten years after the accident

Cytogenetic bio-dosimetry techniques in the detection of dicentric chromosomes induced by ionizing radiation: A review

Ionizing radiation is ubiquitous in the environment. Its source can be natural, such as radioactive materials present in soil and cosmic rays, or artificial, such as the fuel for nuclear power plants. Overexposure to ionizing radiation may damage living tissue and could cause severe health problems (i.e., mutations, radiation sickness, cancer, and death). Cytogenetic bio-dosimetry has the great advantage to take into account the inter-individual variation, and it is informative even when physical dosimetry is not applicable; moreover, it is the definitive method to assess exposure to ionizing radiation recommended by the World Health Organization (WHO). Such a procedure involves counting the frequency of dicentric chromosomes (DCs), which are the most studied chromosomal aberrations used as absorbed radiation biomarkers, during the metaphase of cells. A set of algorithms, tested on different programming languages to automatically identify DCs, is analyzed by the authors together with an Automated Dicentric Chromosome Identifying software (ADCI) mostly based on OpenCV programming libraries. The purpose of this work is to review the main results regarding the correlation between ionizing radiation and dicentric chromosomes in cytogenetic bio-dosimetry

Response of a radiology department to the SARS-CoV-2 pandemic: the experience of the hospital “Policlinico Tor Vergata” in Rome

The dissemination of severe acute respiratory syndrome linked to the novel coronavirus, SARS-CoV-2, prompted all health services to provide adequate measures to limit new cases that could affect healthcare professionals. Due to the large number of suspected patients subjected to CT scans and the proximity of radiologists to the patient during exams, radiologists as well as the entire staff of the radiology department are particularly exposed to SARS-CoV-2. This article includes the emergency management procedures, the use of personal protective devices, and the rearrangement of exam rooms and of human resources in the department of radiology at “Policlinico Tor Vergata” in Rome performed during the SARS-CoV-2 pandemic. We introduce the management measures that our department has taken to cope with the influx of patients while still ensuring the proper management of other emergencies and time-sensitive exams

Electroweak Physics, Experimental Aspects

Collider measurements on electroweak physics are summarised. Although the precision on some observables is very high, no deviation from the Standard Model of electroweak interactions is observed. The data allow to set stringent limits on some models for new physics.Comment: Plenary Talk at the UK Phenomenology Workshop on Collider Physics, Durham, 199

NEMO-SN1 (Western Ionian Sea, off Eastern Sicily): A Cabled Abyssal Observatory with Tsunami Early Warning Capability

The NEMO-SN1 (NEutrino Mediterranean Observatory - Submarine Network 1) seafloor observatory is located in the central Mediterranean, Western Ionian Sea, off Eastern Sicily Island (Southern Italy) at 2100 m water depth, 25 km from the harbour of the city of Catania. It is a prototype of cabled deep-sea multiparameter observatory, and the first operating with real-time data transmission in Europe since 2005. NEMO-SN1 is also the first-established node of EMSO (European Multidisciplinary Seafloor Observatory, http://emso-eu.org), one of the European large-scale research infrastructures. EMSO will address long-term monitoring of environmental processes related to marine ecosystems, climate change and geo-hazards. NEMO-SN1 will perform geophysical and environmental long-term monitoring by acquiring seismological, geomagnetic, gravimetric, accelerometric, physico-oceanographic, hydro-acoustic, bio-acoustic measurements to study earthquake and tsunami generation, and to characterize ambient noise which includes marine mammal sounds, and environmental and anthropogenic sources. NEMO-SN1 is also equipped with a prototype tsunami detector, based on the simultaneous measurement of the seismic and bottom pressure signals and a new high performance tsunami detection algorithm. NEMO-SN1 will be a permanent tsunami early warning node in Western Ionian Sea, an area where very destructive earthquakes have occurred in the past, some of them tsunamigenic (e.g., 1693, M=7.5; 1908, M=7.4). Another important feature of NEMO-SN1 is the installation of a low frequency-high sensibility hydrophone and two (scalar and vector, respectively) magnetometers. The objective is to improve the tsunami detection capability of SN1 through the recognition of tsunami-induced hydro-acoustic and electro-magnetic precursors.SubmittedRhodes, Greece3A. Ambiente Marinorestricte

Design of miniaturized sensors for a mission-oriented uav application: A new pathway for early warning

In recent decades, the increasing threats associated with Chemical and Radiological (CR) agents prompted the development of new tools to detect and collect samples without putting in danger first responders inside contaminated areas. A particularly promising branch of these technological developments relates to the integration of different detectors and sampling systems with Unmanned Aerial Vehicles (UAV). The adoption of this equipment may bring significant benefits for both military and civilian implementations. For instance, instrumented UAVs could be used in support of specialist military teams such as Sampling and Identification of Biological, Chemical and Radiological Agents (SIBCRA) team, tasked to perform sampling in contaminated areas, detecting the presence of CR substances in field and then confirming, collecting and evaluating the effective threats. Furthermore, instrumented UAVs may find dual-use application in the civil world in support of emergency teams during industrial accidents and in the monitoring activities of critical infrastructures. Small size drones equipped with different instruments for detection and collection of samples may enable, indeed, several applications, becoming a tool versatile and easy to use in different fields, and even featuring equipment normally utilized in manual operation. The authors hereby present the design of miniaturized sensors for a mission-oriented UAV application and the preliminary results from an experimental campaign performed in 2020