The phytochemical contents of telferia occidentalis (fluted pumpkin) and the effect of its aqueous extract on blood glucose and enzymatic antioxidant of stress induced Rats

Background: Oxidative stress plays a major role in the development of chronic and degenerative diseases. The human body counteracts oxidative stress by producing antioxidants in situ or acquiring them through food. Objective: To determine the phytochemical content of T. occidentalis and the effects of its aqueous extract on some parameters in stress induced Wistar rats. Methods: The phytochemical content of the leaves was analysed using standard methods. Twenty adult male Wistar rats were divided into 4 groups of 5 rats each (3 test groups and 1 control group) and acclimatized for 3 days. Persistent stress was induced using water immersion induced stress from the 4th to the 17th day. The stressed control group received animal feed and water only, while other stressed groups received animal feed, water and graded dosages of T.occidentalis for 14 days. Blood samples were collected before and after for biochemical parameters. The data obtained from the study were analysed using IBM SPSS Statistics version 21.0. Two way Analysis of Variance was performed and means were separated using Duncan’s new multiple range test. Significance level was set at p<0.05. Results: Flavonoid content of T.occidentalis was 32.60±0.20mg/100g, while alkaloids and carotenoids recorded 496.49±1.37mg/100g and 28.79±0.38mg/100g, respectively. The group treated with T.occidentalis showed a significant (p<0.05) decrease in blood glucose when compared to the stress control. The group treated with the extract showed an increase (p<0.05) in catalase activity but a decrease (p<0.05) in malondialdehyde among the treatment groups of rats compared to the stress control group of rats after 14 day treatment period. Conclusion: This study has proven that Telferia occidentalis is safe for consumption and is an effective tool in stress management

An assessment report on an immunization clinic located in a tertiary institution in Ibadan

Objectives: The aims of the assessment report were to appraise immunization system components and review vaccination coverage between January 2007 and December 2011 at the University College Hospital (UCH) immunization clinic.Methods: The immunization clinic has an annual target population of 997 (for children < one year of age) and 1246 (for pregnant women), which were used in this assessment. The data collection method used included; Key informant - interview, administration of a semi-structured  questionnaire, records review and observations during immunization sessions.Results: The UCH immunization clinic mainly offers fixed sessions and only provides outreach services when there is a need, such as during outbreaks. However, there are no records of vaccinepreventable diseases being  monitored. The coverage rate for nearly all of the vaccines was greater than 100% of the estimated target population for the hospital. Except for the coverage rate of Bacille Calmette Guerin (BCG) vaccine, which peaked in 2011, other vaccines’ coverage peaked in 2009, after which therewas a decline. The highest dropout rate was recorded in 2007, while the rates between 2009 and 2010 were <10%, but the BCG and measles drop out rates were >10% for the 5-year period. For the adult immunizations, yellow fever recorded the highest coverage rate, while the lowest rate was recorded for tetanus toxoid dose 5 (TT5). The vaccines that were most often in short supply included Diphtheria-pertusis-tetanus, Hepatitis B,yellow fever, oral polio, and cerebrospinal meningitis vaccines. Although good-quality supplies, equipment and consumables were observed, there was no inventory of these items. There were evident interpersonal communication and community mobilization as well as capacity building for staff.Conclusion: The assessment showed there was progress in the provision and administration of immunization based on available resources. There is, however, the need to improve documentation of clinic activities

Pattern and trends of respiratory diseases in an outpatient setting: a five-year review in a tertiary hospital in South-South, Nigeria

Background: Limited information exists on the epidemiology of respiratory diseases in South-South Nigeria, especially regarding changing risk factors. This study aimed to assess the frequency and pattern of respiratory diseases in an adult outpatient clinic in a teaching hospital in South-South Nigeria. Methods: Medical records of newly referred patients with respiratory diseases who received care at the chest clinic of Irrua Specialist Teaching Hospital from January 2018 to December 2022 were retrospectively reviewed. Results: The study included 655 patients (mean age: 54.7±18.7 years). The majority of cases occurred in the 41-60 age group, and 55.4% were female. Non-communicable respiratory diseases accounted for 60.9% of cases, while communicable respiratory diseases accounted for 39.1%. The most common respiratory diseases observed were bronchial asthma (22.6%), tuberculosis (21.1%), chronic obstructive pulmonary disease (19.2%), pneumonia (11.1%), interstitial lung diseases (6.7%), and lung cancer (4.1%). Less common respiratory diseases included pulmonary aspergilloma (1.5%), pleural-related diseases (0.8%), hypersensitivity pneumonitis (0.8%), and obstructive sleep apnoea syndrome (0.6%). The study's annual trend showed a gradual increase in the number of respiratory cases, reaching a low point in 2020. Significant differences were found in the age and gender distribution of the top six respiratory diseases (p <0.001). Conclusions: This study provides valuable insights into the demographic and disease patterns of respiratory diseases in an outpatient setting, informing targeted prevention and treatment measures for these conditions

Successful quadruplet surrogate pregnancy after turbulent medical disorders in first trimester

Quadruplet surrogate pregnancy is a rare pregnancy but, has become common due to assisted reproductive technology (ART). Its management is a big challenge to obstetricians and co-clinicians worldwide. This was a pregnancy managed at the University of Nigeria Teaching Hospital (UNTH), Enugu, Nigeria in a 33 year old hypertensive surrogate mother with turbulent first trimester medical disorders that called for termination of the pregnancy by other co-managing clinicians. However, the pregnancy became stable in late 2nd trimester with emergency caesarean section at 33 weeks following preterm premature rupture of membranes (PPROM). Its management was a big challenge that necessitated multidisciplinary approach with successful outcome of four healthy live babies (three males and one female) and the controversial practice of surrogac

Sensitivity of labile carbon fractions to tillage and organic matter management and their potential as comprehensive soil quality indicators across pedoclimatic conditions in Europe

Soil quality is defined as the capacity of the soil to perform multiple functions, and can be assessed by measuring soil chemical, physical and biological parameters. Among soil parameters, labile organic carbon is considered to have a primary role in many soil functions related to productivity and environmental resilience. Our study aimed at assessing the suitability of different labile carbon fractions, namely dissolved organic carbon (DOC), hydrophilic DOC (Hy-DOC), permanganate oxidizable carbon (POXC, also referred to as Active Carbon), hot water extractable carbon (HWEC) and particulate organic matter carbon (POMC) as soil quality indicators in agricultural systems. To do so, we tested their sensitivity to two agricultural management factors (tillage and organic matter input) in 10 European long-term field experiments (LTEs), and we assessed the correlation of the different labile carbon fractions with physical, chemical and biological soil quality indicators linked to soil functions. We found that reduced tillage and high organic matter input increase concentrations of labile carbon fractions in soil compared to conventional tillage and low organic matter addition, respectively. POXC and POMC were the most sensitive fractions to both tillage and fertilization across the 10 European LTEs. In addition, POXC was the labile carbon fraction most positively correlated with soil chemical (total organic carbon, total nitrogen, and cation exchange capacity), physical (water stable aggregates, water holding capacity, bulk density) and biological soil quality indicators (microbial biomass carbon and nitrogen, and soil respiration). We conclude that POXC represents a labile carbon fraction sensitive to soil management and that is the most informative about total soil organic matter, nutrients, soil structure, and microbial pools and activity, parameters commonly used as indicators of various soil functions, such as C sequestration, nutrient cycling, soil structure formation and soil as a habitat for biodiversity. Moreover, POXC measurement is relatively cheap, fast and easy. Therefore, we suggest measuring POXC as the labile carbon fraction in soil quality assessment schemes in addition to other valuable soil quality indicators.</p

Melanogenesis, Its Regulatory Process, and Insights on Biomedical, Biotechnological, and Pharmacological Potentials of Melanin as Antiviral Biochemical

Melanin is s most widely distributed pigment and is found in bacteria, fungi, plants, and animals. Melanogenesis is under complex regulatory control by multiple agents interacting through pathways activated by hormonal and receptor-dependent and -independent mechanisms. There are about 20 genes that are involved in the biochemical pathway of melanogenesis and its regulation, which include: tyrosinase, microphthalmia-associated transcription factor, melanocortin1 receptor, adenylate cyclase, protein kinase A. Human melanogenesis regulatory proteins such as MAPK1, CREB3, and CREBP, have binary interaction with the protein of herpesvirus, hepatitis C virus, Human immunodeficiency virus type 1, Simian virus 40, and Human adenovirus A and C. Melanin is a double-edged sword in host-pathogen interaction (e.g., human-bacteria and/or fungi interaction). The inducers of upregulation of melanogenesis include fluvoxamine, famotidine, terbutaline, heliotrine, sirolimus, dicoumarol, Prestwick-860, carbimazole, (-)-MK-801, rilmenidine, hydrastine hydrochloride, haloperidol, scopolamine N-oxide, raubasine, and dihydroergocristine. In melanogenesis, GSK3B, CSNK2A, MAPK1, MAPK3, MAPK14, ERK1, and HIPK2 were the major kinases, while RUNX1, GATA1, and REST, SUN12, and RCOR1 were the major transcription factors. This study has reviewed the melanogenesis pathway, its regulations as well as applications to viral infection. The antiviral activity of melanin and its complex in the presence of antibacterial and antifungal compounds should be investigated to further provide insight for biomedical, biotechnological, and pharmacological applications

Setting priorities for ageing research in Africa: a systematic mapping review of 512 studies from sub-Saharan Africa

BACKGROUND: In 2040, the older population's growth rate in sub-Saharan Africa (SSA) will be faster than those experienced by developed nations since 1950. In preparation for this growth, the National Institute on Aging commissioned the National Academies' Committee on Population to organize a workshop on advancing aging research in Africa. This meeting provided a platform for discussing some areas requiring improvement in aging research in SSA regions. We believed that conducting a systematic review of peer-reviewed articles to set priorities for aging research in SSA is warranted. Therefore, this article is the first in a Four-Part series that summaries the types and trends of peer-reviewed studies in SSA. METHODS: This systematic mapping review followed the Search-Appraisal-Synthesis-Analysis Framework. We systematically searched multiple databases from inception till February 2021 and included peer-reviewed articles conducted with/for older adults residing in SSA. Conventional content analysis was employed to categorize studies into subject-related areas. RESULTS: We included 512 studies (quantitative = 426, qualitative = 71 and mixed-method = 15). Studies were conducted in 32 countries. Quantitative studies included were observational studies: cross-sectional (n = 250, 59%), longitudinal (n = 126, 30%), and case-control (n = 12, 3%); and experimental studies: pre-post design (n = 4, 1%), randomized control trial (RCT, n = 12, 3%); and not reported (n = 21, 5%). Fifteen qualitative studies did not state their study design; where stated, study design ranged from descriptive (n = 14, 20%), ethnography (n = 12, 17%), grounded theory (n = 7, 10%), narrative (n = 5, 7%), phenomenology (n = 10, 14%), interpretative exploratory (n = 4, 6%), case studies (n = 4, 6%). Of the 15 mixed-method studies, seven did not state their mixed-method design. Where stated, design includes concurrent (n = 1), convergent (n = 1), cross-sectional (n = 3), informative (n = 1), sequential exploratory (n = 1) and retrospective (n = 2). Studies were classified into 30 (for quantitative studies) and seven (for qualitative and mixed-method) subject-related areas. HIV/AIDs-related and non-communicable diseases-related studies were the most predominant subject-related areas. No studies explored the transdisciplinary co-production of interventions. CONCLUSIONS: There are glaring gaps in ageing research in SSA, especially mixed-methods and RCTs. A large number of studies focused on HIV/AIDs and non-communicable disease-related studies. National and international funding agencies should set up priority funding competitions for transdisciplinary collaborations in ageing research

Cardio-respiratory emergencies

No Abstract.ABSUMSAJ Vol. 2 (1) 2000: pp. 36-3

Utilitarian Qubit, Human Geography, and Pandemic Preparedness in the 21st Century

Human actions are ambivalent in nature and this in turn has an impact on all components of socio-ecological systems. Their ambivalence results from the fact that human actions have both positive and negative outcomes and properties, which occur and manifest concurrently in the ontological realm of human existence. In terms of space&ndash;time, both micro-geography and macro-geography of human existence are intertwined during the COVID-19 pandemic, thus affecting pre- and post-pandemic space&ndash;time continuum. The utilitarian qubit can be used to describe the nature of human existence, i.e., Homo sapiens has always been experiencing a state of existence where pain and pleasure are co-extensive. In this state, it is impossible to establish to what extent pain, and to what extent pleasure, will have a definitive impact on our status as individuals and humanity as a species. In this article, the authors explore how the record of an individual&rsquo;s life before and after the COVID-19 pandemic has been impacted by the wellbeing and actions of other humans and prior to one&rsquo;s existence. Drawing on the utilitarian qubit, the COVID-19 pandemic, and its impacts on the members of Homo sapiens, can be understood as a partial outcome of the cumulative actions of humanity on the biosphere and other elements of the global ecosystem (the Age of the Anthropocene). We argue that this paper is also useful to foster disaster preparedness and resilience in the pandemic and post-pandemic era, at micro- and macro-geographical interfaces of human existence in the 21st century. The existence of individual members of Homo sapiens and humanity as a species is unfolding at the boundary between two levels: fundamental reality and situational reality. The result is the historical accumulation and ontological interconnectedness of humanity&rsquo;s activities with one&rsquo;s own actions. Pain and pleasure resulting from the COVID-19 pandemic and the Age of Anthropocene, as well as the right and wrong consequences of humanity&rsquo;s actions, are posited here to be symptoms of the Anthropocenic (phase of) epidemiological transition

Информационно-аналитические программы на государственных телевизионных каналах

Assessing soil microbial functionality has the potential to reveal meaningful effects of soil management on soil processes influencing soil quality. We used MicroResp™ to assess microbial respiration upon the addition of six carbon substrates (glucose, alanine, aminobutyric acid, N-acetyl glucosamine, alpha-ketoglutaric acid, and lignin). From this, we calculated the multiple substrate induced respiration (MSIR), the microbial catabolic profile expressed as absolute and relative utilization rate, and the Shannon microbial functional diversity index (H′). We tested the effect of tillage (reduced vs. conventional) and organic matter addition (high vs. low) on these microbial parameters in soil from 10 European long-term field experiments (LTEs), and investigated their relationships with labile organic carbon fractions and various soil parameters linked to soil functions. Reduced tillage and high organic matter input increased MSIR compared to conventional tillage and low organic matter input. In addition, reduced tillage resulted in a small but significant increase in functional diversity compared to conventional tillage. An increase in soil management intensity (CT-Low > CT-High > RT-Low > RT-High) was associated with lower utilization of all the substrates expressed as absolute utilization rate, and a proportionately higher utilization of alpha-ketoglutaric acid compared to the other substrates. More intensive management systems also showed lower soil quality as measured by various soil parameters, in particular total and labile organic carbon, basal respiration, and microbial biomass nitrogen. The present work shows for the first time the key role of labile organic carbon, as affected by soil management, in determining microbial functional diversity. Aggregating results from 10 European arable LTEs, making use of a comprehensive dataset, MicroResp™ showed that reduced tillage and increased organic matter addition created a more favourable habitat for the microbial community to utilize different carbon substrates and, thereby, the potential for nutrient cycling.</p