3 research outputs found
Changing plasma cytokine, chemokine and growth factor profiles upon differing malaria transmission intensities
Background: Malaria epidemiological and immunological data suggest that parasite tolerance wanes in the absence
of continuous exposure to the parasite, potentially enhancing pathogenesis. The expansion of control interventions
and elimination campaigns raises the necessity to better understand the host factors leading to susceptibility or
tolerance that are afected by rapid changes in malaria transmission intensity (MTI). Mediators of cellular immune
responses are responsible for the symptoms and pathological alterations during disease and are expected to change
rapidly upon malaria exposure or cessation.
Methods: The plasma concentrations of 30 cytokine, chemokine and growth factors in individuals of all ages from
a malaria endemic area of southern Mozambique were compared between 2 years of diferent MTI: 2010 (lower,
n=234) and 2013 (higher, n=143). The efect of the year on the correlations between cytokines, chemokines and
growth factors and IgGs to Plasmodium falciparum (markers of exposure) was explored. The efects of age, sex, neighbourhood and parasitaemia on analyte levels and their interactions with year were also assessed.
Results: An inverse correlation of several cellular immune mediators with malarial antibodies in 2013, and a lack of
correlation or even a positive correlation in 2010 were observed. Most cytokines, chemokines and growth factors,
regardless of their immune function, had higher concentrations in 2010 compared with 2013 in P. falciparum-infected
and uninfected subjects. Age and neighbourhood showed an efect on analyte concentrations.
Conclusions: The results show a diferent regulation of the cellular immune response in 2010 vs 2013 which could
be related to a loss of immune-tolerance after a decline in MTI in 2010 and previous years, and a rapid re-establishment of tolerance as a consequence of more continuous exposure as MTI began increasing in 2012. Cellular immune
mediators warrant further investigation as possible surrogates of MTI-associated host susceptibility or tolerance
Evaluation of a universal coverage bed net distribution campaign in four districts in Sofala Province, Mozambique
Changing plasma cytokine, chemokine and growth factor profiles upon differing malaria transmission intensities
Background: Malaria epidemiological and immunological data suggest that parasite tolerance wanes in the absence
of continuous exposure to the parasite, potentially enhancing pathogenesis. The expansion of control interventions
and elimination campaigns raises the necessity to better understand the host factors leading to susceptibility or
tolerance that are afected by rapid changes in malaria transmission intensity (MTI). Mediators of cellular immune
responses are responsible for the symptoms and pathological alterations during disease and are expected to change
rapidly upon malaria exposure or cessation.
Methods: The plasma concentrations of 30 cytokine, chemokine and growth factors in individuals of all ages from
a malaria endemic area of southern Mozambique were compared between 2 years of diferent MTI: 2010 (lower,
n=234) and 2013 (higher, n=143). The efect of the year on the correlations between cytokines, chemokines and
growth factors and IgGs to Plasmodium falciparum (markers of exposure) was explored. The efects of age, sex, neighbourhood and parasitaemia on analyte levels and their interactions with year were also assessed.
Results: An inverse correlation of several cellular immune mediators with malarial antibodies in 2013, and a lack of
correlation or even a positive correlation in 2010 were observed. Most cytokines, chemokines and growth factors,
regardless of their immune function, had higher concentrations in 2010 compared with 2013 in P. falciparum-infected
and uninfected subjects. Age and neighbourhood showed an efect on analyte concentrations.
Conclusions: The results show a diferent regulation of the cellular immune response in 2010 vs 2013 which could
be related to a loss of immune-tolerance after a decline in MTI in 2010 and previous years, and a rapid re-establishment of tolerance as a consequence of more continuous exposure as MTI began increasing in 2012. Cellular immune
mediators warrant further investigation as possible surrogates of MTI-associated host susceptibility or tolerance