Submillimeter Sources behind the Massive Lensing Clusters A370 and A2390

We report 850 μm Submillimeter Array (SMA) observations of four gravitationally lensed submillimeter galaxies (SMGs), A370-2, A2390-1, A2390-3, and A2390-4, which were originally discovered with the Submillimeter Common-User Bolometer Array (SCUBA). Our SMA detection of A370-2 with a submillimeter flux of 7.95 ± 0.60 mJy unambiguously identifies the counterparts to this source at optical and radio wavelengths. A2390-1 is an ultraluminous infrared galaxy with a submillimeter flux of 5.55 ± 0.92 mJy and a redshift of 1.8 ± 0.2 computed from submillimeter/radio flux ratio analysis. We resolve A2390-3 into two components, A2390-3a and A2390-3b, with fluxes of 3.15 ± 0.63 mJy and 1.92 ± 0.60 mJy, respectively. The structure of the system could be consistent with morphological distortion by gravitational lensing. The lack of counterparts in the optical and infrared indicates a heavily dust-enshrouded nature, and a non-detection in the radio implies that these two sources probably lie at z > 4.7, which would make them among the most distant SMGs known to date. Our non-detection of A2390-4 suggests either that there are multiple fainter submillimeter sources within the SCUBA beam or that the SCUBA detection may have been false. Our precise positions allow us to determine accurate amplifications and fluxes for all of our detected sources. Our new results give a shallower power-law fit (–1.10) to the faint-end 850 μm cumulative number counts than previous work. We emphasize the need for high-resolution observations of single dish detected SMGs in order to measure accurately the faint end of the 850 μm counts

Fisetin Protects Against Hepatic Steatosis Through Regulation of the Sirt1/AMPK and Fatty Acid β-Oxidation Signaling Pathway in High-Fat Diet-Induced Obese Mice

Background/Aims: Fisetin is a naturally abundant flavonoid isolated from various fruits and vegetables that was recently identified to have potential biological functions in improving allergic airway inflammation, as well as anti-oxidative and anti-tumor properties. Fisetin has also been demonstrated to have anti-obesity properties in mice. However, the effect of fisetin on nonalcoholic fatty liver disease (NAFLD) is still elusive. Thus, the present study evaluated whether fisetin improves hepatic steatosis in high-fat diet (HFD)-induced obese mice and regulates lipid metabolism of FL83B hepatocytes in vitro. Methods: NAFLD was induced by HFD in male C57BL/6 mice. The mice were then injected intraperitoneally with fisetin for 10 weeks. In another experiment, FL83B cells were challenged with oleic acid to induce lipid accumulation and treated with various concentrations of fisetin. Results: NAFLD mice treated with fisetin had decreased body weight and epididymal adipose tissue weight compared to NAFLD mice. Fisetin treatment also reduced liver lipid droplet and hepatocyte steatosis, alleviated serum free fatty acid, and leptin concentrations, significantly decreased fatty acid synthase, and significantly increased phosphorylation of AMPKα and the production of sirt-1 and carnitine palmitoyltransferase I in the liver tissue. In vitro, fisetin decreased lipid accumulation and increased lipolysis and β-oxidation in hepatocytes. Conclusion: This study suggests that fisetin is a potential novel treatment for alleviating hepatic lipid metabolism and improving NAFLD in mice via activation of the sirt1/AMPK and β-oxidation pathway

Revisiting the Color-Color Selection: Submillimeter and AGN Properties of NUV-r-J Selected Quiescent Galaxies

We examine the robustness of the color-color selection of quiescent galaxies (QGs) against contamination of dusty star-forming galaxies using the latest submillimeter data. We selected 18,304 QG candidates out to $z\sim$ 3 using the commonly adopted $NUV-r-J$ selection based on the high-quality multi-wavelength COSMOS2015 catalog. Using extremely deep 450 and 850 $\mu$m catalogs from the latest JCMT SCUBA-2 Large Programs, S2COSMOS, and STUDIES, as well as ALMA submillimeter, VLA 3 GHz, and $Spitzer$ MIPS 24 $\mu$m catalogs, we identified luminous dusty star-forming galaxies among the QG candidates. We also conducted stacking analyses in the SCUBA-2 450 and 850 $\mu$m images to look for less-luminous dusty galaxies among the QG candidates. By cross-matching to the 24 $\mu$m and 3 GHz data, we were able to identify a sub-group of "IR-radio-bright" QGs who possess a strong 450 and 850 $\mu$m stacking signal. The potential contamination of these luminous and less-luminous dusty galaxies accounts for approximately 10% of the color-selected QG candidates. In addition, there exists a spatial correlation between the luminous star-forming galaxies and the QGs at a $\lesssim60$ kpc scale. Finally, we found a high QG fraction among radio AGNs at $z<$ 1.5. Our data show a strong correlation between QGs and radio AGNs, which may suggest a connection between the quenching process and the radio-mode AGN feedback.Comment: This paper is accepted for publication on Ap

Th2 cytokine bias induced by silver nanoparticles in peripheral blood mononuclear cells of common bottlenose dolphins (Tursiops truncatus)

Background Silver nanoparticles (AgNPs) have been widely used in many commercial products due to their excellent antibacterial ability. The AgNPs are released into the environment, gradually accumulate in the ocean, and may affect animals at high trophic levels, such as cetaceans and humans, via the food chain. Hence, the negative health impacts caused by AgNPs in cetaceans are of concern. Cytokines play a major role in the modulation of immune system and can be classified into two types: Th1 and Th2. Th1/Th2 balance can be evaluated by the ratios of their polarizing cytokines (i.e., interferon [IFN]-γ/Interleukin [IL]-4), and animals with imbalanced Th1/Th2 response may become more susceptible to certain kinds of infection. Therefore, the present study evaluated the in vitro cytokine responses of cetacean peripheral blood mononuclear cells (cPBMCs) to 20 nm citrate-AgNPs (C-AgNP20) by quantitative reverse transcriptase polymerase chain reaction (qRT-PCR). Methods Blood samples were collected from six captive common bottlenose dolphins (Tursiops truncatus). The cPBMCs were isolated and utilized for evaluating the in vitro cytokine responses. The cytokines evaluated included IL-2, IL-4, IL-10, IL-12, interferon (IFN)-γ, and tumor necrosis factor (TNF)-α. The geometric means of two housekeeping genes (HKGs), glyceraldehyde 3-phosphate dehydrogenase (GAPDH) and β2-microglobulin (B2M), of each sample were determined and used to normalize the mRNA expression levels of target genes. Results The ratio of late apoptotic/necrotic cells of cPBMCs significantly increased with or without concanavalin A (ConA) stimulation after 24 h of 10 µg/ml C-AgNP20 treatment. At 4 h of culture, the mRNA expression level of IL-10 was significantly decreased with 1 µg/ml C-AgNP20 treatment. At 24 h of culture with 1 µg/ml C-AgNP20, the mRNA expression levels of all cytokines were significantly decreased, with the exceptions of IL-4 and IL-10. The IFN-γ/IL-4 ratio was significantly decreased at 24 h of culture with 1 µg/ml C-AgNP20 treatment, and the IL-12/IL-4 ratio was significantly decreased at 4 or 24 h of culture with 0.1 or 1 µg/ml C-AgNP20 treatment, respectively. Furthermore, the mRNA expression level of TNF-α was significantly decreased by 1 µg/ml C-AgNP20 after 24 h of culture. Discussion The present study demonstrated that the sublethal dose of C-AgNP20 (≤1 µg/ml) had an inhibitory effect on the cytokine mRNA expression levels of cPBMCs with the evidence of Th2 cytokine bias and significantly decreased the mRNA expression level of TNF-α. Th2 cytokine bias is associated with enhanced immunity against parasites but decreased immunity to intracellular microorganisms. TNF-α is a contributing factor for the inflammatory response against the infection of intracellular pathogens. In summary, our data indicate that C-AgNP20 suppresses the cellular immune response and thereby increases the susceptibility of cetaceans to infection by intracellular microorganisms

A large population of strongly lensed faint submillimetre galaxies in future dark energy surveys inferred from JWST imaging

Bright galaxies at sub-millimetre wavelengths from Herschel are now well known to be predominantly strongly gravitationally lensed. The same models that successfully predicted this strongly lensed population also predict about one percent of faint $450{\mu}$m-selected galaxies from deep JCMT surveys will also be strongly lensed. Follow-up ALMA campaigns have so far found one potential lens candidate, but without clear compelling evidence e.g. from lensing arcs. Here we report the discovery of a compelling gravitational lens system confirming the lensing population predictions, with a $z_{s} = 3.4 {\pm} 0.4$ submm source lensed by a $z_{spec} = 0.360$ foreground galaxy within the COSMOS field, identified through public JWST imaging of a $450{\mu}$m source in the SCUBA-2 Ultra Deep Imaging EAO Survey (STUDIES) catalogue. These systems will typically be well within the detectable range of future wide-field surveys such as Euclid and Roman, and since sub-millimetre galaxies are predominantly very red at optical/near-infrared wavelengths, they will tend to appear in near-infrared channels only. Extrapolating to the Euclid-Wide survey, we predict tens of thousands of strongly lensed near-infrared galaxies. This will be transformative for the study of dusty star-forming galaxies at cosmic noon, but will be a contaminant population in searches for strongly lensed ultra-high-redshift galaxies in Euclid and Roman.Comment: 8 pages; 4 figures; 4 tables; submitted to MNRA

Elevated Aspartate and Alanine Aminotransferase Levels and Natural Death among Patients with Methamphetamine Dependence

Background: Methamphetamine is one of the fastest growing illicit drugs worldwide, causing multiple organ damage and excessive natural deaths. The authors aimed to identify potential laboratory indices and clinical characteristics associated with natural death through a two-phase study. Methods: Methamphetamine-dependent patients (n = 1,254) admitted to a psychiatric center in Taiwan between 1990 and 2007 were linked with a national mortality database for causes of death. Forty-eight subjects died of natural causes, and were defined as the case subjects. A time-efficient sex-and age-matched nested case-control study derived from the cohort was conducted first to explore the potential factors associated with natural death through a time-consuming standardized review of medical records. Then the identified potential factors were evaluated in the whole cohort to validate the findings. Results: In phase I, several potential factors associated with natural death were identified, including aspartate aminotransferase (AST), alanine aminotransferase (ALT), comorbid alcohol use disorder, and the prescription of antipsychotic drugs. In phase II, these factors were confirmed in the whole cohort using survival analysis. For the characteristics at the latest hospital admission, Cox proportional hazards models showed that the adjusted hazard ratios for natural death were 6.75 (p&lt;0.001) in the group with markedly elevated AST (&gt;80 U/L) and 2.66 (p&lt;0.05) in the group with mildly elevated AST (40-80 U/L), with reference to the control group (&gt;40 U/L). As for ALT, the adjusted hazard ratios were 5.41 (p&lt;0.001), and 1.44 (p&gt;0.05). Comorbid alcohol use disorder was associated with an increased risk of natural death, whereas administration of antipsychotic drugs was not associated with lowered risk. Conclusions: This study highlights the necessity of intensive follow-up for those with elevated AST and ALT levels and comorbid alcohol use disorder for preventing excessive natural deaths