Differentiation and Protective Capacity of Virus-Specific CD8

Noroviruses can establish chronic infections with active viral shedding in healthy humans but whether persistence is associated with adaptive immune dysfunction is unknown. We used genetically engineered strains of mouse norovirus (MNV) to investigate CD8+ T cell differentiation during chronic infection. We found that chronic infection drove MNV-specific tissue-resident memory (Trm) CD8+ T cells to a differentiation state resembling inflationary effector responses against latent cytomegalovirus with only limited evidence of exhaustion. These MNV-specific Trm cells remained highly functional yet appeared ignorant of ongoing viral replication. Pre-existing MNV-specific Trm cells provided partial protection against chronic infection but largely ceased to detect virus within 72 hours of challenge, demonstrating rapid sequestration of viral replication away from T cells. Our studies revealed a strategy of immune evasion by MNV via the induction of a CD8+ T cell program normally reserved for latent pathogens and persistence in an immune-privileged enteric niche. Chronic infections often cause T cell dysfunction, but how noroviruses (NV) evade immunity is unknown. Tomov et al. show that gut-resident T cells against NV remain functional but ignorant of chronic viral replication, suggesting that NV persists in an immune-privileged enteric niche. © 2017 Elsevier Inc

Experimental demonstration of 10 Gb/s multilevel carrier-less amplitude and phase modulation for short range optical communication systems

2012-2013 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe

The Better-Than-Average Effect in Hong Kong and the United States: The Role of Personal Trait Importance and Cultural Trait Importance

People tend to make self-aggrandizing social comparisons on traits that are important to the self. However, existing research on the better-than-average effect (BTAE) and trait importance does not distinguish between personal trait importance (participants’ ratings of the importance of certain traits to themselves) and cultural trait importance (participants’ perceptions of the importance of the traits to the cultural group to which they belong). We demonstrated the utility of this distinction by examining the joint effects of personal importance and cultural importance on the BTAE among Hong Kong Chinese and American participants. Results showed that the BTAE was more pronounced for personally important traits among both Chinese and American participants. More important, the magnitude of the BTAE was smaller on culturally important traits among Chinese participants only. Chinese participants displayed the strongest BTAE on personally important and culturally unimportant traits, and the smallest BTAE on personally unimportant and culturally important ones. American participants showed the smallest BTAE on personally and culturally unimportant traits. These findings underscore the importance of distinguishing personal trait importance and cultural trait importance in understanding the cultural effects on self-aggrandizing social comparisons. They further suggest that in cultures where people are expected to be modest in self-expression (e.g., Chinese culture), people would avoid claiming superiority on highly culturally important traits even when these traits are important to the self

Effects of Trade Cost on the Textile and Apparel Market: Evidence from Asian Countries

Global textile and apparel industry has since the 1950s been subjected to various forms of trade policy measures. Well noted among these are tariffs and non-tariff barriers (NTB)/policy indicators. Understanding the dynamics in such relevant policy indicators and the implications they yield for trade is a vital step toward informing relevant policy formulation and agribusiness investment decisions. With the textile and apparel industry being the primary grounds on which development in most Asian countries is founded, we for the first time in literature assess effects of various trade cost indicators on global textile and apparel imports from 37 Asian countries using a ‘cost-incorporated’ gravity model for the period 1988–2004. Estimates from this study affirm theory-based associations between trade, distance, cultural linkage, tariffs, and non-tariffs barriers. We however discovered quite interesting associations regarding effects of tariff increments and existence of NTB. Although both are primarily imposed/instilled to restrict trade flow, effect of tariff increments was consistently negative across all models, but that for NTB was consistently positive, although significant only in the case of apparel imports. Plausible reasons behind the implications for tariffs and NTB are elaborated on in this article. A keen discovery from this study, however, is that imports of apparels are more responsive than textile imports to dynamics in various trade-related cost, geographic and economic indicators