1,315 research outputs found
Geometry-controlled kinetics
It has long been appreciated that transport properties can control reaction
kinetics. This effect can be characterized by the time it takes a diffusing
molecule to reach a target -- the first-passage time (FPT). Although essential
to quantify the kinetics of reactions on all time scales, determining the FPT
distribution was deemed so far intractable. Here, we calculate analytically
this FPT distribution and show that transport processes as various as regular
diffusion, anomalous diffusion, diffusion in disordered media and in fractals
fall into the same universality classes. Beyond this theoretical aspect, this
result changes the views on standard reaction kinetics. More precisely, we
argue that geometry can become a key parameter so far ignored in this context,
and introduce the concept of "geometry-controlled kinetics". These findings
could help understand the crucial role of spatial organization of genes in
transcription kinetics, and more generally the impact of geometry on
diffusion-limited reactions.Comment: Submitted versio
Multiwavelength Observations of Pulsar Wind Nebulae
The extended nebulae formed as pulsar winds expand into their surroundings
provide information about the composition of the winds, the injection history
from the host pulsar, and the material into which the nebulae are expanding.
Observations from across the electromagnetic spectrum provide constraints on
the evolution of the nebulae, the density and composition of the surrounding
ejecta, the geometry of the central engines, and the long-term fate of the
energetic particles produced in these systems. Such observations reveal the
presence of jets and wind termination shocks, time-varying compact emission
structures, shocked supernova ejecta, and newly formed dust. Here I provide a
broad overview of the structure of pulsar wind nebulae, with specific examples
from observations extending from the radio band to very-high-energy gamma-rays
that demonstrate our ability to constrain the history and ultimate fate of the
energy released in the spin-down of young pulsars.Comment: 20 pages, 11 figures. Invited review to appear in Proc. of the
inaugural ICREA Workshop on "The High-Energy Emission from Pulsars and their
Systems" (2010), eds. N. Rea and D. Torres, (Springer Astrophysics and Space
Science series
Intravesical Ty21a vaccine promotes dendritic cells and T cell-mediated tumor regression in the MB49 bladder cancer model
Preclinical data shows that intravesical instillation of Ty21a/Vivotif\uae, a commercial vaccine against typhoid fever, is an effective alternative option to standard Bacillus-Calmette-Gu\ue9rin (BCG) immunotherapy for nonmuscle-invasive bladder cancer (NMIBC). Here we characterized the inflammatory effects of Ty21a on the bladder and investigated the immune mechanisms underlying tumor-regression towards the use of this bacterial vaccine in NMIBC patients. MB49 bladder tumor-bearing mice had significantly improved survival after intravesical instillations of Ty21a doses of 106 to 108 colony-forming units. By immunohistochemistry and morphology, both BCG and Ty21a instillations were associated with bladder inflammation, which was decreased with the use of low, but effective, doses of Ty21a. Flow cytometry analysis showed a significant infiltration of T cells, natural killer (NK) cells, and myeloid cells, compared with controls, after a single dose of Ty21a, whereas this was only observed after multiple doses of BCG. The induced myeloid cells were predominantly neutrophils and Ly6C+CD103+ dendritic cells (DC), the latter being significantly more numerous after instillation of Ty21a than BCG. Ex vivo infection of human leukocytes with Ty21a, but not BCG, similarly significantly increased DC frequency. CD4+ and CD8+ T cells, but not NK cells nor neutrophils, were required for effective Ty21a bladder tumor responses. Thus, the generation of antitumor adaptive immunity was identified as a key process underlying Ty21a-mediated treatment efficacy. Altogether, these results demonstrate mechanisms of intravesical Ty21a therapy and suggest its potential as a safe and effective treatment for NMIBC patients
X-Ray Emitting Blast Wave from the Recurrent Nova RS Ophiuchi
Stellar explosions such as novae and supernovae produce most of the heavy
elements in the Universe. Although the onset of novae from runaway
thermonuclear fusion reactions on the surface of a white dwarf in a binary star
system is understood[1], the structure, dynamics, and mass of the ejecta are
not well known. In rare cases, the white dwarf is embedded in the wind nebula
of a red-giant companion; the explosion products plow through the nebula and
produce X-ray emission. Early this year, an eruption of the recurrent nova RS
Ophiuchi[2,3] provided the first opportunity to perform comprehensive X-ray
observations of such an event and diagnose conditions within the ejecta. Here
we show that the hard X-ray emission from RS Ophiuchi early in the eruption
emanates from behind a blast wave, or outward-moving shock wave, that expanded
freely for less than 2 days and then decelerated due to interaction with the
nebula. The X-rays faded rapidly, suggesting that the blast wave deviates from
the standard spherical shell structure[4-6]. The early onset of deceleration
indicates that the ejected shell had a low mass, the white dwarf has a high
mass[7], and that RS Ophiuchi is a progenitor of the type of supernova integral
to studies of the expansion of the universe.Comment: To appear in Nature; 7 pages, including 2 color figures; removed
incorrect statement of embargo polic
Spatial heterogeneity of habitat suitability for Rift Valley fever occurrence in Tanzania: an ecological niche modelling approach
Despite the long history of Rift Valley fever (RVF) in Tanzania, extent of its suitable habitat in the country remains unclear. In this study we investigated potential effects of temperature, precipitation, elevation, soil type, livestock density, rainfall pattern, proximity to wild animals, protected areas and forest on the habitat suitability for RVF occurrence in Tanzania. Presence-only records of 193 RVF outbreak locations from 1930 to 2007 together with potential predictor variables were used to model and map the suitable habitats for RVF occurrence using ecological niche modelling. Ground-truthing of the model outputs was conducted by comparing the levels of RVF virus specific antibodies in cattle, sheep and goats sampled from locations in Tanzania that presented different predicted habitat suitability values. Habitat suitability values for RVF occurrence were higher in the northern and central-eastern regions of Tanzania than the rest of the regions in the country. Soil type and precipitation of the wettest quarter contributed equally to habitat suitability (32.4% each), followed by livestock density (25.9%) and rainfall pattern (9.3%). Ground-truthing of model outputs revealed that the odds of an animal being seropositive for RVFV when sampled from areas predicted to be most suitable for RVF occurrence were twice the odds of an animal sampled from areas least suitable for RVF occurrence (95% CI: 1.43, 2.76, p < 0.001). The regions in the northern and central-eastern Tanzania were more suitable for RVF occurrence than the rest of the regions in the country. The modelled suitable habitat is characterised by impermeable soils, moderate precipitation in the wettest quarter, high livestock density and a bimodal rainfall pattern. The findings of this study should provide guidance for the design of appropriate RVF surveillance, prevention and control strategies which target areas with these characteristics
Observational and Physical Classification of Supernovae
This chapter describes the current classification scheme of supernovae (SNe).
This scheme has evolved over many decades and now includes numerous SN Types
and sub-types. Many of these are universally recognized, while there are
controversies regarding the definitions, membership and even the names of some
sub-classes; we will try to review here the commonly-used nomenclature, noting
the main variants when possible. SN Types are defined according to
observational properties; mostly visible-light spectra near maximum light, as
well as according to their photometric properties. However, a long-term goal of
SN classification is to associate observationally-defined classes with specific
physical explosive phenomena. We show here that this aspiration is now finally
coming to fruition, and we establish the SN classification scheme upon direct
observational evidence connecting SN groups with specific progenitor stars.
Observationally, the broad class of Type II SNe contains objects showing strong
spectroscopic signatures of hydrogen, while objects lacking such signatures are
of Type I, which is further divided to numerous subclasses. Recently a class of
super-luminous SNe (SLSNe, typically 10 times more luminous than standard
events) has been identified, and it is discussed. We end this chapter by
briefly describing a proposed alternative classification scheme that is
inspired by the stellar classification system. This system presents our
emerging physical understanding of SN explosions, while clearly separating
robust observational properties from physical inferences that can be debated.
This new system is quantitative, and naturally deals with events distributed
along a continuum, rather than being strictly divided into discrete classes.
Thus, it may be more suitable to the coming era where SN numbers will quickly
expand from a few thousands to millions of events.Comment: Extended final draft of a chapter in the "SN Handbook". Comments most
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