Production of aspirated phonemes in Cantonese-speaking children with cochlear implants or hearing aids

Also available in print.Includes bibliographical references.A dissertation submitted in partial fulfilment of the requirements for the Bachelor of Science (Speech and Hearing Sciences), The University of Hong Kong, June 30, 2008.Thesis (B.Sc)--University of Hong Kong, 2008.published_or_final_versionSpeech and Hearing SciencesBachelorBachelor of Science in Speech and Hearing Science

Realization of Woodpile Structure Using Optical Interference Holography

We report the use of a (4+1)-beam optical interference holography technique to fabricate woodpile structures in photo-resists. The configuration consists of 4 linear polarized side beams arranged symmetrically around a circular polarized central beam with all the beams from the same half space, making it easily accessible experimentally. The fabricated woodpile structures are in good agreement with model simulations. Furthermore, woodpiles with the diamond symmetry are also obtained by exploiting the deformations of the photo-resists. Directional bandgaps in the visible range are also observed for the samples with and without the correct stacking of the woodpile structures.Comment: 9 pages and three figure

Quantum spin fluctuations in dynamical quantum phase transitions

Quantum phase transitions have long been studied in their relation to quantum fluctuations. These fluctuations can be quantified as the degree of spin squeezing in spin models, where one of the two non-commutative observables breaks the standard quantum limit of measurement by minimizing its uncertainty. However, the understanding of their role in dynamical quantum phase transitions (DQPTs) is still incomplete. In this work, we combine the Loschmidt amplitude, which detects DQPTs, and the spin-squeezing parameter (SSP), the quantification of spin squeezing, to study the spin dynamics in a quenched interacting spin model around DQPT. We show that the extremal, mostly maximal, of SSP occurs near DQPTs when the system is quenched between different phases. These phenomena further unveil the spin correlations during DQPTs, for which the highest contribution aligns with the preferred direction of spin interactions in the post-quenched phase. We also demonstrate the time evolution of SSP differs for various quench scenarios. These findings provide us with physical insights into the dynamics of quantum fluctuations around DQPTs and their relation to the equilibrium phase diagrams.Comment: 12 pages, 15 figure

Exploring perceptions of braille on common everyday objects

Tactile writing sometimes has an advantage over purely visually presented text. As a form of tactile text, braille might be usable for tactile writing. If braille as tactile writing is usable on everyday objects, the amount of braille in the environment would increase and people might be encouraged to learn it, simultaneously addressing the decline in braille literacy. However, sighted individuals might perceive braille nega- tively. A preliminary study was thus conducted to gauge possible negative perceptions. A number of brailled and unbrailled ceramic bowls were fabricated and distributed, with questionnaires, at a public event. The process of fabrication and the question- naire responses suggest adding braille to studio ceramics is not straightforward, but a resistance to the addition of braille to objects is not expected. The study was limited in scope and the exploration of additional techniques, development of specialized tools, and further studies involving different objects and materials are recommended

Is 'oil pulling' a 'snake oil'? : a clinical trial

The traditional Ayurveda practice of ‘oil pulling’ has become a recent phenomenon and concerns about its efficacy have been raised. Objectives: (1) to determine awareness about the practice of ‘oil pulling’ among a group of young adults, and to determine variations in awareness with respect to socio-demographic factors, oral health behaviours (oral hygiene and dental attendance) and use of natural health products; (2) to determine the effectiveness of ‘oil pulling’ and conventional oral hygiene practice compared to the use of conventional oral hygiene practice alone in terms of oral hygiene and (3) to determine the effectiveness of ‘oil pulling’ and conventional oral hygiene practice compared to the use of conventional oral hygiene practice alone in terms of gingival health. Methods: Group members recruited seventy-four young adults to participate in a clinical trial over a two-month period comparing the effectiveness of (a) ‘oil pulling’ and conventional oral hygiene methods (toothbrush and toothpaste) versus (b) conventional oral hygiene methods alone. Oral hygiene was assessed using the Plaque Index - PI (Silness and Löe, 1964) and the proportion of sites with visible plaque (PVP). Gingival health was assessed using the Gingival Index – GI (Silness and Löe,1963) and the proportion of sites with gingival bleeding (PGB). Participants were block randomized in groups of four to a cross over clinical trial and assessments were conducted at one-month and two-months. Results: Approximately a quarter (28.4%, 21) of participants was aware of the practice of ‘oil pulling’. Awareness of the practice was associated with reported use of natural dental/oral health products (p0.05). There were observed significant differences in gingival health among both the test and control groups from baseline to one-month (p0.05). No significant differences were observed in oral health parameters from one-month to two-month among neither the test nor control groups (p>0.05). Conclusion: Awareness of the practice of ‘oil pulling’ is relatively common and is associated with use of natural dental/oral health products. Findings from the clinical trial failed to support the adjunct use of ‘oil pulling’ in addition to conventional oral hygiene practices.published_or_final_versio

Topical CpG Oligodeoxynucleotide Adjuvant Enhances the Adaptive Immune Response against Influenza A Infections

Current influenza vaccines generate humoral immunity, targeting highly variable epitopes and thus fail to achieve long-term protection. T cells recognize and respond to several highly conserved epitopes across influenza serotypes. A strategy of raising strong cytotoxic T cell memory responses to epitopes conserved across serotypes would provide cross serotype protection, eliminating the need for annual vaccination. We explored the adjuvant potential of epicutaneous (ec) and subcutaneous (sc) delivery of CpG oligodeoxynucleotide in conjunction with subcutaneous protein immunization to improve protection against influenza A virus infections using a mouse model. We found enhanced long-term protection with ecCpG compared to scCpG as demonstrated by reduced viral titers in the lungs. This correlated with increased antigen-specific CD8 T cells in the airways and the lungs. The memory T cell response after immunization with ecCpG adjuvant was comparable to memory response by priming with influenza A virus infection in the lungs. In addition, ecCpG was more efficient than scCpG in inducing the generation of IFN-γ producing CD4 T cells. The adjuvant effect of ecCpG was accompanied with its ability to modulate tissue-homing molecules on T cells that may direct them to the site of infection. Together, this work provides evidence for using ecCpG to induce strong antibody and memory T cell responses to confer protection against influenza A virus infection

Lgr5 and Col22a1 mark progenitor cells in the lineage toward juvenile articular chondrocytes

The synovial joint forms from a pool of progenitor cells in the future region of the joint, the interzone. Expression of Gdf5 and Wnt9a has been used to mark the earliest cellular processes in the formation of the interzone and the progenitor cells. However, lineage specification and progression toward the different tissues of the joint are not well understood. Here, by lineage-tracing studies we identify a population of Lgr5+ interzone cells that contribute to the formation of cruciate ligaments, synovial membrane, and articular chondrocytes of the joint. This finding is supported by single-cell transcriptome analyses. We show that Col22a1, a marker of early articular chondrocytes, is co-expressed with Lgr5+ cells prior to cavitation as an important lineage marker specifying the progression toward articular chondrocytes. Lgr5+ cells contribute to the repair of a joint defect with the re-establishment of a Col22a1-expressing superficial layer

Assessment of intellectual impairment, health-related quality of life, and behavioral phenotype in patients with neurotransmitter related disorders Data from the iNTD registry

Inherited disorders of neurotransmitter metabolism are a group of rare diseases, which are caused by impaired synthesis, transport, or degradation of neurotransmitters or cofactors and result in various degrees of delayed or impaired psychomotor development. To assess the effect of neurotransmitter deficiencies on intelligence, quality of life, and behavior, the data of 148 patients in the registry of the International Working Group on Neurotransmitter Related Disorders (iNTD) was evaluated using results from standardized age-adjusted tests and questionnaires. Patients with a primary disorder of monoamine metabolism had lower IQ scores (mean IQ 58, range 40-100) within the range of cognitive impairment (<70) compared to patients with a BH4 deficiency (mean IQ 84, range 40-129). Short attention span and distractibility were most frequently mentioned by parents, while patients reported most frequently anxiety and distractibility when asked for behavioral traits. In individuals with succinic semialdehyde dehydrogenase deficiency, self-stimulatory behaviors were commonly reported by parents, whereas in patients with dopamine transporter deficiency, DNAJC12 deficiency, and monoamine oxidase A deficiency, self-injurious or mutilating behaviors have commonly been observed. Phobic fears were increased in patients with 6-pyruvoyltetrahydropterin synthase deficiency, while individuals with sepiapterin reductase deficiency frequently experienced communication and sleep difficulties. Patients with BH4 deficiencies achieved significantly higher quality of life as compared to other groups. This analysis of the iNTD registry data highlights: (a) difference in IQ and subdomains of quality of life between BH4 deficiencies and primary neurotransmitter-related disorders and (b) previously underreported behavioral traits