Fast Computation of the Fitness Function for Protein Folding Prediction in a 2D Hydrophobic-Hydrophilic Model

Protein Folding Prediction (PFP) is essentially an energy minimization problem formalised by the definition of a fitness function. Several PFP models have been proposed including the Hydrophobic-Hydrophilic (HP) model, which is widely used as a test-bed for evaluating new algorithms. The calculation of the fitness is the major computational task in determining the native conformation of a protein in the HP model and this paper presents a new efficient search algorithm (ESA) for deriving the fitness value requiring only O(n) complexity in contrast to the full search approach, which takes O(n2). The improved efficiency of ESA is achieved by exploiting some intrinsic properties of the HP model, with a resulting reduction of more than 50% in the overall time complexity when compared with the previously reported Caching Approach, with the added benefit that the additional space complexity is linear instead of quadratic

Enablers and barriers to involvement in commercialisation

Universities are facing growing pressure to contribute towards innovation which has social impact and which contributes to economic development. Researchers mainly in the Science and Engineering fields are the primary sources of innovation outputs from universities and as such their involvement in commercialisation activities directly adds to the growth of innovative outputs from publicly financed research. Technology Transfer Offices (TTO) have been established at universities across South Africa to foster the involvement of researchers in commercialisation activities, to champion the innovation conversation within higher education institutions and to progress innovations from concept to application in society. This study focussed on understanding the factors which enable or create a barrier to the involvement of researchers in commercialisation activities at the Nelson Mandela Metropolitan University. The key elements examined in this study include the researchers’ perception of enablers (monetary and nonmonetary incentives) and barriers to involvement at national, institutional and individual levels. This study undertook to understand the perceptions of researchers of enablers and barriers to involvement in commercialisation at the Nelson Mandela Metropolitan University. Researchers in the two faculties of Science and Engineering, Built Environment and Information Technology were approached to anonymously complete an electronic survey, the questions for which were developed from literature. The results from the survey were analysed using descriptive statistics and hypothesis testing. This study finds that a combination of incentives is necessary to enable researcher involvement and to lower barriers to involvement in commercialisation research. A set of recommendations based on the study are put forward on how such recommendations can be implemented

Osteoporosis-pseudoglioma syndrome in South Africa

The osteoporosis-pseudoglioma syndrome (MIM 259770) is a rare autosomal recessive disorder in which bone fragility and frequent fractures are associated with serious ocular changes. The skeletal manifestations resemble those of osteogenesis imperfecta while hyperplasia of the vitreous, eye and corneal opacities often mimics the appearance of intraocular glioma. This disorder was previously reported in a South African family of Indian stock as 'the ocular form of osteogenesis imperfecta'. Terminological discussion followed and it was suggested that these individuals had osteoporosis-pseudoglioma syndrome. This article describes and depicts the manifestations of the disorder and discusses the nosology.DHE

The Need for Active Debt Management in Financially Challenged Municipalities in the Free State Province

Published ArticleIn terms of section 155(4) of the Constitution of the Republic of South Africa, 1996, all municipalities (metropolitan, district and local municipalities) are expected to raise their own revenues in addition to the transfers they receive from national government. This principle is an important feature of any democratic local government system, creating a revenue-service link between the municipality and its customers that empowers customers to hold the municipality directly accountable for the services it provides. However, municipalities’ own revenue collection has been significantly declining as a result of greater reliance placed on intergovernmental transfers as a revenue source. It is of concern that in many cases, the funds dedicated to service delivery, development and growth are being mismanaged by municipal officials, and in many instances due to political interference. Therefore, the purpose of the study was to identify debt management, its consequences, and the development of an integrated debt management model for municipalities in the Free State Province. This article provides a theoretical review of debt management, legislative frameworks for local government financial administration as well as the challenges facing municipalities in financial distress within the Free State Province regarding debt management. The article concludes by discussing the integrated debt management model as a result of conclusions drawn from the theoretical and the empirical study. The article argues that the integrated debt management model as an intervention can be operationalised to assist financially challenged municipalities in the Free State Province with current debt management challenges

Pyle metaphyseal dysplasia in an African child: Case report and review of the literature

Pyle disease (OMIM 265900), also known as metaphyseal dysplasia, is a rare autosomal recessive disorder with no known gene mutation. We report a case of Pyle disease in a 7-year-old African boy of mixed ancestry who presented with finger and wrist fractures following minor trauma. The radiological findings revealed abnormally broad metaphyses of the tubular bones, known as Erlenmeyer-flask bone deformity, and mild cranial sclerosis, both hallmarks of the condition. We report the first case in a patient with African ancestry, which could help in the gene discovery of this rare autosomal recessive skeletal dysplasia with unknown mutations.DHE

Incident HIV during pregnancy and early postpartum period: a population-based cohort study in a rural area in KwaZulu-Natal, South Africa

BACKGROUND: The evidence on the effect of pregnancy on acquiring HIV is conflicting, with studies reporting both higher and lower HIV acquisition risk during pregnancy when prolonged antiretroviral therapy was accessible. The aim of this study was to assess the pregnancy effect on HIV acquisition where antiretroviral therapy was widely available in a high HIV prevalence setting. METHODS: This is a retrospective cohort study nested within a population-based surveillance to determine HIV incidence in HIV-uninfected women from 15 to 49 years from 2010 through 2015 in rural KwaZulu-Natal. HIV incidence per 100 person-years according to pregnancy status (not pregnant, pregnant, to eight weeks postpartum) were measured in 5260 HIV-uninfected women. Hazard ratios (HR) were estimated by Cox proportional hazards regression with pregnancy included as a time varying variable. RESULTS: Overall, pregnancy HIV incidence was 4.5 per 100 person-years (95% CI 3.4-5.8), higher than non-pregnancy (4.0; 95% CI 3.7-4.3) and postpartum incidences (4.2 per 100 person-years; 95% CI 2.3-7.6). However, adjusting for age, and demographic factors, pregnant women had a lower risk of acquiring HIV (HR 0.4; 95% CI 0.2-0.9, P = 0.032) than non-pregnant women; there were no differences between postpartum and non-pregnant women (HR 1.2; 95% CI 0.4-3.2; P = 0.744). In models adjusting for the interaction of age and gravidity, pregnant women under 25 years with two or more pregnancies had a 2.3 times greater risk of acquiring HIV than their older counterparts (95% CI 1.3-4.3; P = 0.008). CONCLUSIONS: Pregnancy had a protective effect on HIV acquisition. Elevated HIV incidence in younger women appeared to be driven by those with higher gravidity. The sexual and biological factors in younger women should be explored further in order to design appropriate HIV prevention interventions

Review of the radiographic modalities used during dental implant therapy - A narrative

The introduction of digital x-ray receivers which replaced conventional films was a significant radiographic development that is commonly used in daily dental practice. Dental implant therapy (DIT) is a sought after dental therapeutic intervention and dental radiography is an essential component contributing to the success of treatment. Dental radiographs taken in daily practice are generally conventional two-dimensional images and/or three-dimensional images. Ideally, the choice of radiographic technique should be determined after a thorough clinical examination and comprehensive consideration of the advantages, indications, and drawbacks. Digital three-dimensional modalities that have emerged over the last decade have been incorporated into DIT with the assumption that treatment outcomes will be improved. These modalities are constantly being reassessed and improved but there is a paucity of published information regarding the assessment of variables such as dosages and dimensional accuracy, suggesting that further research in these matters is necessary. This is crucial in order to obtain evidence-based information that may influence future radiographic practices. In this narrative, the authors present the most commonly used dental radiographic modalities currently used in DIT