10 research outputs found
Multicenter, open-label, non-comparative study of a combination of polytar and zinc pyrithione shampoo in the management of dandruff
Background: Dandruff is a common condition in clinical practice. We
undertook a study to evaluate the efficacy and safety of a combination
of zinc pyrithione and polytar in a shampoo base for the treatment of
dandruff. Methods: A combination of polytar (1%) and zinc pyrithione
(1%) was used for 4 weeks to treat 954 patients suffering from mild to
severe dandruff. Scoring of dandruff was done on a 0-10 scale for each
of the 6 regions of scalp at weeks 0, 2, 4 and 6. Follow up was for 2
weeks. Results: There was consistent improvement in dandruff scores
over the treatment and the follow up period. There was significant
improvement in signs and symptoms such as erythema and itching, with a
negligible adverse event profile. The global assessment by
investigators showed good-excellent results in the majority of patients
and there was high acceptability for the treatment among the patients.
Conclusion: A combination shampoo of polytar (1%) and zinc pyrithione
(1%) offers a safe and effective option in the treatment of dandruff
and its associated symptoms
Multicenter, open-label, non-comparative study of a combination of polytar and zinc pyrithione shampoo in the management of dandruff
Dandruff is a common condition in clinical practice. We undertook a study to evaluate the efficacy and safety of a combination of zinc pyrithione and polytar in a shampoo base for the treatment of dandruff. Methods: A combination of polytar (1%) and zinc pyrithione (1%) was used for 4 weeks to treat 954 patients suffering from mild to severe dandruff. Scoring of dandruff was done on a 0-10 scale for each of the 6 regions of scalp at weeks 0, 2, 4 and 6. Follow up was for 2 weeks. Results: There was consistent improvement in dandruff scores over the treatment and the follow up period. There was significant improvement in signs and symptoms such as erythema and itching, with a negligible adverse event prof ile. The global assessment by investigators showed good-excellent results in the majority of patients and there was high acceptability for the treatment among the patients. Conclusion: A combination shampoo of polytar (1%) and zinc pyrithione (1%) offers a safe and effective option in the treatment of dandruff and its associated symptoms
A clinical and mycological study of onychomycosis in HIV infection
Background: Onychomycosis is one of the early manifestations of HIV
infection with a prevalence of 15-40%. Multiple nail involvement,
isolation of both common and rare species, and resistance to treatment
are the characteristics of onychomycosis in HIV. Aim: To study the
epidemiology, clinical manifestations of onychomycosis in HIV-infected
individuals and to identify the various causative fungi
microbiologically. Methods: A total of 250 HIV infected patients,
diagnosed by ELISA, were screened for nail involvement; of which 60
patients i.e., 40 males and 20 females, who had clinically suspected
untreated fungal infection were included in this study. Results: Of
the 60 respondents, 34 (56.66%) were from the 31-40 years age group.
Amongst the 40 males, there were 20 manual laborers and 14 farmers;
while 18 of 20 females were housewives. Toenail involvement was seen in
38 patients (63.33%), fingernail in 12 patients (20%) while 10 (16.66%)
patients had involvement of both. Twenty eight (46.66%) patients gave
history of some trauma, 6 (10%) had diabetes mellitus, and only 1
patient (1.66%) had history of peripheral vascular disease. Nineteen
(31.66%) patients had associated tinea pedis, 5 (8.33%) had tinea
manuum, 10 (16.66%) had tinea corporis and 7 (11.66%) had tinea cruris.
Twenty one (35%) respondents had distal and lateral superficial
onychomycosis (DLSO), 5 (8.33%) had proximal subungual onychomycosis
(PSO), 1 (1.66%) had superficial white onychomycosis (SWO), while 33
(55%) had total dystrophic onychomycosis (TDO). Fungal elements were
demonstrated by KOH mount in 49 patients (81.66%) and growth was seen
in 32 (53.33%) cultures. Dermatophytes were isolated in 13 (21.66%) and
nondermatophytic molds (NDM) in 19 (31.66%). Out of the 13 positive
dermatophyte cultures, Trichophyton rubrum was isolated on 11 and
Trichophyton mentagrophytes on 2 cultures. Of the 19 non-dermatophytic
cultures, Aspergillus niger was isolated on 3 and Candida spp. on 12
while Cladosporium spp., Scytalidium hyalinum, Penicillium spp., and
Gymnoascus dankaliensis on 1 each. Conclusions: Total dystrophic
onychomycosis was the most common clinical type and NDM were the
predominant causative organisms
Kojic acid vis-a-vis its combinations with hydroquinone and betamethasone valerate in melasma: A randomized, single blind, comparative study of efficacy and safety
Background: Melasma is a relatively common, acquired symmetric hypermelanosis characterized by irregular light to gray-brown macules involving sun-exposed areas. Kojic acid, with its depigmenting potential due to tyrosinase inhibition and suppression of melanogenesis, has become a vital component of the dermatologists′ armamentarium against melasma. Aim: To study and compare the efficacy of kojic acid 1% alone, vis-a-vis its separate combinations with 2% hydroquinone or 0.1% betamethasone valerate and a combination of all these three agents with respect to the duration of symptoms and level of pigmentation in the therapy of melasma. Materials and Methods: Eighty patients from a single tertiary care center objectively assessed by calculating the melasma area severity index (MASI) and randomized (simple randomization) into four parallel groups (A, B, C, and D) of 20 each were prescribed once daily local application at night, (participants blinded regarding the difference in identity of interventions), as follows:
Group A - kojic acid 1% cream.
Group B - kojic acid 1% and hydroquinone 2% cream.
Group C - kojic acid 1% and betamethasone valerate 0.1% cream.
Group D - kojic acid 1%, hydroquinone 2%, and betamethasone valerate 0.1% cream.
Strict photoprotection and use of a SPF 15 sunscreen was advised during the day. Patients were evaluated every 2 weeks and a fall in MASI score was calculated at the end of the study period of 12 weeks by the same investigator. Results: The response was compared according to percentage decrease in MASI score. Efficacy was evaluated among the groups at the end of 3 months using bivariate analysis and calculated by using the paired ′t′ test. The clinical efficacy of group B was the highest followed closely by group D and group A, that of group C being the lowest. Conclusion: Kojic acid in synergy with hydroquinone is a superior depigmenting agent as compared with other combinations