Critical Review on Beeja Doshaj Pandu Roga in Bala Roga w.s.r. to Thalassemia

Thalassemia syndromes are most common single gene disorder in the world and represent a major health burden worldwide. It is a heterogeneous disorder recessively inherited resulting from various mutations of the genes which code for globin chains of Hb leading to reduced or absent synthesis of globin chains. In Ayurveda, Aacharya Charaka described Beeja Dushti Janya Vikaara. He explained that specific Avayava would be Vikrita, if Doshas vitiate specific Beeja or Beejabhaaga. Scientists are working to remove excess iron in order to prevent or delay iron overload which is achieved by prolonging blood transfusion interval and searching effective, orally administrable, economical iron chelators to combat the Thalassemia. In Ayurveda Raktashodhana, Raktaprasaadana, Shonitasthaapana, Rasayana, Balya and Varnya properties decrease the rapid destruction of RBCs and thus prolonging the Life span of RBCs which increases the interval of blood transfusion. All these factors increase the expectancy of good life of Thalassemic patients

Critical review on Mandabuddhitva in children and role of Samvardhana Ghrita in treatment

Ayurveda, which is the science of life, also called an eternal science; deals with spiritual, psychological and physical well being of the individual. Ayurveda being the science of life deals with all its aspects including the aspect of psyche. Although not explained in separate chapters, still conditions referred by our Acharyas as “Alpabuddhi, Mudha, Jada, Abudh” (indicating stunted growth of mental faculties) appear to be state of ‘mental retardation’ these conditions have been attributed to impaired development of buddhi. Mandabuddhitva can be correlated with Mental retardation. Mental retardation is a disorder consisting of below average intellectual functioning and impairment in adaptive skill, which is present, before the person is 18 years of age. This is the period when the brain along with the entire nervous system is in a state of development in order to reach maturity. In Ayurveda Samvardhana Ghrita mentioned by Acharya Kashyapa in the management of Mandabuddhitva

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CRITICAL REVIEW ON PREGNANCY INDUCED HYPERTENSION (PIH) IN AYURVEDA</div

A Critical review on Pharmacodynamics of Basti Chikitsa and its action on Enteric Nervous System

Ayurveda being an ancient science it has developed through many experiences and experiment in medicines. Panchakarma therapy is a very imperative and essential part of Ayurvedic treatment. Panchakarma (Vaman,Virechan, Nasya, Anuvasan &amp; niruha) practices to get complete cure of disease, Basti is the main treatment as it possesses a wide spectrum of effects and is thought to be the Ardhachikitsa (50% of all treatment modality) in Ayurveda. Though Basti is given in the Pakvashaya (Rectum and Colon) its active ingredients i.e. “Virya of the Basti” spreads in the entire body to get desire action. BastiVirya may act through enteric nervous system (ENS). The gastrointestinal system has a network of nerve fibres, which is known as ‘Enteric Nervous System (ENS). Similar to brain, ENS sends and receives impulses; record experiences and responds to various stimuli. </jats:p

Bacillus As Potential Probiotics: Status, Concerns, and Future Perspectives

Spore-forming bacilli are being explored for the production and preservation of food for many centuries. The inherent ability of production of large number of secretory proteins, enzymes, antimicrobial compounds, vitamins, and carotenoids specifies the importance of bacilli in food chain. Additionally, Bacillus spp. are gaining interest in human health related functional food research coupled with their enhanced tolerance and survivability under hostile environment of gastrointestinal tract. Besides, bacilli are more stable during processing and storage of food and pharmaceutical preparations, making them more suitable candidate for health promoting formulations. Further, Bacillus strains also possess biotherapeutic potential which is connected with their ability to interact with the internal milieu of the host by producing variety of antimicrobial peptides and small extracellular effector molecules. Nonetheless, with proposed scientific evidences, commercial probiotic supplements, and functional foods comprising of Bacillus spp. had not gained much credential in general population, since the debate over probiotic vs pathogen tag of Bacillus in the research and production terrains is confusing consumers. Hence, it’s important to clearly understand the phenotypic and genotypic characteristics of selective beneficial Bacillus spp. and their substantiation with those having GRAS status, to reach a consensus over the same. This review highlights the probiotic candidature of spore forming Bacillus spp. and presents an overview of the proposed health benefits, including application in food and pharmaceutical industry. Moreover, the growing need to evaluate the safety of individual Bacillus strains as well as species on a case by case basis and necessity of more profound analysis for the selection and identification of Bacillus probiotic candidates are also taken into consideration

Antimicrobial Resistance: Its Surveillance, Impact, and Alternative Management Strategies in Dairy Animals

Antimicrobial resistance (AMR), one among the most common priority areas identified by both national and international agencies, is mushrooming as a silent pandemic. The advancement in public health care through introduction of antibiotics against infectious agents is now being threatened by global development of multidrug-resistant strains. These strains are product of both continuous evolution and un-checked antimicrobial usage (AMU). Though antibiotic application in livestock has largely contributed toward health and productivity, it has also played significant role in evolution of resistant strains. Although, a significant emphasis has been given to AMR in humans, trends in animals, on other hand, are not much emphasized. Dairy farming involves surplus use of antibiotics as prophylactic and growth promoting agents. This non-therapeutic application of antibiotics, their dosage, and withdrawal period needs to be re-evaluated and rationally defined. A dairy animal also poses a serious risk of transmission of resistant strains to humans and environment. Outlining the scope of the problem is necessary for formulating and monitoring an active response to AMR. Effective and commendably connected surveillance programs at multidisciplinary level can contribute to better understand and minimize the emergence of resistance. Besides, it requires a renewed emphasis on investments into research for finding alternate, safe, cost effective, and innovative strategies, parallel to discovery of new antibiotics. Nevertheless, numerous direct or indirect novel approaches based on host–microbial interaction and molecular mechanisms of pathogens are also being developed and corroborated by researchers to combat the threat of resistance. This review places a concerted effort to club the current outline of AMU and AMR in dairy animals; ongoing global surveillance and monitoring programs; its impact at animal human interface; and strategies for combating resistance with an extensive overview on possible alternates to current day antibiotics that could be implemented in livestock sector