Publisher Correction: Truncated FGFR2 is a clinically actionable oncogene in multiple cancers.

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Ages "plomb total" déterminés sur des zircons du Précambrien de la région de Frederikshab (côte sud-ouest du Groenland)

Zircons contained in five specimens of gneiss from different formations of the Isorssua area (E of Frederikshab, SW Greenland) have revealed the following "total lead" ages: 2755, 2725, 2680, 2630, 2620 Ma. They fit well with the main group of K-Ar ages (2500 to 2700 Ma) known from other localities from the pre-ketilidian basement, but are, however, in average slightly older; this may be explained by the fact that they correspond to an earlier stage of the cooling of the basement and are also less sensitive to later thermal influences. The first two ages (2755 and 2725 Ma) come from non-migmatitic rocks, which are interstratified in the predominantly migmatitic gneiss (2680 to 2620 Ma). The older age of these more refractory rocks results from less complete recrystallisation of the zircons, some inherited material having thus been preserved. The extent of rejuvenation of the zircons therefore appears to depend, thermal conditions being equal, upon the chemical composition of the whole rock. K-Ar ages measured on biotites in the same rocks from the same area approximate 1800 Ma (Larsen, 1966). This discordance is a distant effect of the ketilidian orogeny, which completely rejuvenated the biotites but did not affect the zircons

Patient satisfaction with cardiac rehabilitation: association with utilization, functional capacity, and heart-health behaviors

Saba Ali,1 Caroline Chessex,2 Rebecca Bassett-Gunter,1 Sherry L Grace1,2 1School of Kinesiology and Health Science, York University, 2Toronto Rehabilitation Institute, University Health Network, University of Toronto, Toronto, ON, Canada Background: Cardiac rehabilitation (CR) societies recommend assessment of patient satisfaction given its association with health care utilization and outcomes. Recently, the Patient Assessment of Chronic Illness Care (PACIC, Glasgow) was recommended as an appropriate tool for the CR setting. The objectives of this study were to 1) describe patient satisfaction with CR, 2) test the psychometric properties of the PACIC in the CR setting, and 3) assess the association of patient satisfaction with CR utilization and outcomes.Methods: Secondary analysis was conducted on an observational, prospective CR program evaluation cohort. A convenience sample of patients from 1 of 3 CR programs was approached at their first CR visit, and consenting participants completed a survey. Clinical data were extracted from charts pre- and post-program. Participants were e-mailed surveys again 6 months (including the PACIC) and 1 and 2 years later.Results: Of 411 consenting patients, 247 (60.2%) completed CR. The mean PACIC score was 2.8±1.1/5. Internal reliability was α=0.95. The total PACIC score varied significantly by site (F=3.12, P=0.046), indicating discriminant validity. Patient satisfaction was significantly related to greater CR adherence (r=0.22, P<0.01) and completion (t=2.63, P<0.01), greater functional status at CR discharge (r=0.17, P=0.03) and 2 years post-intake (r=0.19, P=0.03), greater physical activity at discharge (r=0.18, P=0.02), as well as lower depressive symptoms at discharge (r=-0.16, P=0.02) and 1-year follow-up (r=-0.19, P=0.03). These associations sustained adjustment for sex.Conclusion: Patients were relatively satisfied with their care. The PACIC is a psychometrically validated scale, which could serve as a useful tool to assess patient satisfaction with CR. Keywords: cardiac rehabilitation, patient satisfaction, cardiovascular disease, program evaluatio

Estimating Neonatal Oxygen Consumption from Heart Rate

ABSTRACT The relationship between heart rate (HR) and oxygen consumption (V̇o2) has been investigated in a sample of 20 low‐risk, term neonates aged 14–48 hrs. Repeated, simultaneous measurements of HR and V̇o2 were performed on each neonate during each of three epochs ordered by increasing level of activity. A robust linear relationship was found between HR and V̇o2, with an average correlation of.90. Substantial variation was observed across individuals in the slope of the HR‐V̇o2 regression line. This variation was curvilinearly related to ponderal index (PI), with low PI neonates having the shallowest and steepest slopes. These findings suggest that HR may provide a flexible, non‐restrictive means of estimating neonatal V̇o2 but that the impact of prenatal growth history and postnatal growth performance on the estimation of V̇o2 from HR merits further investigation

Premature atherosclerosis in HIV-infected individuals--focus on protease inhibitor therapy.

OBJECTIVE: Lipid disorders associated with the use of protease inhibitors may contribute to the premature development of atherosclerosis. The purpose of the present study was to determine whether the administration of a protease inhibitor-containing regimen to middle-aged (30-50 years) HIV-infected individuals for 6 months or longer is associated with an increased prevalence of atherosclerosis. METHODS: High-resolution B-mode ultrasound imaging was used to visualize the femoral and carotid arteries of 68 HIV-negative and 168 HIV-infected individuals, including 136 patients who had received protease inhibitors for 26.8 +/- 8.9 months (mean +/- SD). Atherogenic plaques were defined as a thickening of the intima-media > or = 1200 mm. RESULTS: The proportion of participants with one or more plaques was higher in the HIV-infected group in comparison with the HIV-negative group (55 versus 38%; P = 0.02), and so was the prevalence of cigarette smoking (61 versus 46%; P = 0.03) and hyperlipidaemia (56 versus 24%; P < 0.001). The presence of plaque was independently associated with age, male gender, plasma low-density lipoprotein cholesterol levels and smoking. In univariate logistic regression analysis, an association was also found with HIV infection. Among HIV-infected subjects protease inhibitor therapy was not associated with the presence of plaque. CONCLUSIONS: A large proportion of the middle-aged HIV-infected individuals examined during this study had one or more atherosclerotic plaques within the femoral or carotid arteries. The presence of peripheral atherosclerosis within this population is not associated with the use of protease inhibitors, but rather with 'classic' cardiovascular risk factors such as smoking and hyperlipidaemia, which are amenable to interventions

Debio 0617B Inhibits Growth of STAT3-Driven Solid Tumors through Combined Inhibition of JAK, SRC, and Class III/V Receptor Tyrosine Kinases.

Tumor survival, metastases, chemoresistance, and escape from immune responses have been associated with inappropriate activation of STAT3 and/or STAT5 in various cancers, including solid tumors. Debio 0617B has been developed as a first-in-class kinase inhibitor with a unique profile targeting phospho-STAT3 (pSTAT3) and/or pSTAT5 in tumors through combined inhibition of JAK, SRC, ABL, and class III/V receptor tyrosine kinases (RTK). Debio 0617B showed dose-dependent inhibition of pSTAT3 in STAT3-activated carcinoma cell lines; Debio 0617B also showed potent antiproliferative activity in a panel of cancer cell lines and in patient-derived tumor xenografts tested in an in vitro clonogenic assay. Debio 0617B showed in vivo efficacy by inhibiting tumor growth in several mouse xenograft models. To increase in vivo efficacy and STAT3 inhibition, Debio 0617B was tested in combination with the EGFR inhibitor erlotinib in a non-small cell lung cancer xenograft model. To evaluate the impact of in vivo STAT3 blockade on metastases, Debio 0617B was tested in an orthotopic tumor model. Measurement of primary tumor weight and metastatic counts in lung tissue demonstrated therapeutic efficacy of Debio 0617B in this model. These data show potent activity of Debio 0617B on a broad spectrum of STAT3-driven solid tumors and synergistic activity in combination with EGFR inhibition. Mol Cancer Ther; 15(10); 2334-43. ©2016 AACR