OIL PRICES-GROWTH NEXUS IN ALGERIA USING THE MEDAS MODEL

Objective: This Article aims to investigate the impact of oil price fluctuations on economic growth in Algeria using the Mixed Data Sampling (MIDAS) model during the period 1990-2022   Theoretical Framework: The theoretical aspect addressed the different time-frequency models by defining the Midas models and addressing the weighting functions used in estimating these models.   Method: Estimating the relationship between a high-frequency variable (oil price) and a low-frequency variable (economic growth rate GDP) using the MIDAS model using Almon's PDL Weighting Function.   Results and Discussion: The results of the study concluded economic growth in Algeria is directly affected by oil prices, The study also found that MIDAS models have a great predictive ability, allowing researchers to utilize all available information for high-frequency variables, instead of using annual average values that lose a lot of information. avoid converting low-frequency variables to match high-frequency variables, reducing econometric issues in model diagnostics.   Research Implications: Research Implications: It is suggested that rentier countries such as Algeria work to diversify their economy away from oil, and follow up the process of economic diversification and accelerate it during periods of high fuel prices by working to develop non-strategic sectors as agriculture, tourism and manufacturing industries.   Originality/Value: These results are expected to benefit policymakers in government, by urging them to invest in renewable energies as a crucial strategy for achieving sustainable development and a key factor in mitigating oil price shocks, particularly during recent recurring global crises. Future research directions include exploring existing gaps and promoting standardized studies

A Predictive Study of Electricity Consumption Fluctuations Using the Autoregressive-Moving-Average Models: Wilaya of Medea as a Case Study (2011-2017)

تهدف هذه الدراسة إلى نمذجة استهلاك الكهرباء في ولاية المدية باستخدام نماذج الانحدار الذاتي والمتوسطات المتحركة للفترة من جانفي 2011 إلى ديسمبر 2017 والتي تشمل 84 مشاهدة ، ومن ثم التنبؤ بالاستهلاك في المدى القصير، وقد توصلت الدراسة إلى أن الكهرباء المستهلكة تتبع نموذج SARMA(4 ,0) في شكل نموذج جدائي ذو اتجاه عام متزايد. تصنيف جال: E21، C35، C 25، C53.The study aims to model the consumption of electricity in the Wilaya “Town” of Medea by using the autoregressive–moving-average models for the period from January 2011 to December 2017, which includes 84 views and then the prediction of consumption in a short term, the study found that the electricity consumed follows the model (4.0) ASARMA. In a form of a multiplicative model of Increasing general trend

Regressive dynamics of vegetation of Setif high plains : erosion of plant diversity in djebel Youssef (Algeria)

The extensive degradation of the vegetation of djebel Youssef (Setif High Plains) is mainly due to the anthropozoic action,worsened by very constraining climatic conditions, including recurrent periods of droughts. The flora and vegetation of this mountain had not been previously studied. Surveys that we have undertaken show the presence of a relatively rich and varied flora. To follow the evolution of the flora and vegetation, we conducted a diachronic study of 10 years. Results presented in this paper are the first observations for the decade 2000-2010. Regression of vegetation was accompanied by depletion of phanerophytes and proliferation of therophytes. At a very advanced dematorralization already succeeded a steppe, resulting from an extensive therophytization highlighted by the analysis of biological spectra. The flora is thus constituted by 70 % therophytes and marked by the scarcity of phanerophytes (7 %). The relative importance of desert species (over 12 % of the saharan-arabic species), indicates the progressive aridity of the regionLa dégradation très avancée de la végétation du djebel Youssef (hautes plaines sétifiennes) est due essentiellement à l'action anthropozoïque, aggravée par des conditions climatiques très contraignantes, notamment des périodes de sécheresse récurrentes. La flore et la végétation de ce massif n'avaient fait l'objet jusqu'ici d'aucune étude scientifique. Les prospections que nous avons entreprises font ressortir la présence d'une flore relativement riche et variée. Du fait de l'absence de travaux floristiques, nous nous sommes proposé de suivre l'évolution de la flore et de la végétation à partir d'une étude diachronique de 10 années. Les résultats que nous présentons dans ce travail constituent le fruit des premières observations pour la décennie 2000-2010. La régression de la végétation s'est accompagnée de la raréfaction des ligneux et de la prolifération des thérophytes. À une dématorralisation déjà très poussée a succédé une steppisation, résultat d'une importante thérophytisation mise en lumière par l'analyse des spectres biologiques. La flore est ainsi constituée par 70 % de thérophytes et marquée par la rareté des phanérophytes (7 %). L'importance relative des espèces désertiques, plus de 12 % des espèces relevant surtout de l'élément saharo-arabique, dénote l'aridification progressive de la région

Predictive Model Based on K-Nearest Neighbor Coupled with the Gray Wolf Optimizer Algorithm (KNN_GWO) for Estimating the Amount of Phenol Adsorption on Powdered Activated Carbon

In this work, the adsorption mechanism of phenol on activated carbon from aqueous solutions was investigated. Batch experiments were performed as a function of adsorbent rate, solution temperature, phenol initial concentration, stirring speed, and pH. The optimal operating condition of phenol adsorption were: mass/volume ratio of 0.6 g.L−1, temperature of 20 °C and stirring speed of 300 rpm. The equilibrium data for the adsorption of phenol were analyzed by Langmuir, Freundlich, and Temkin isotherm models. It was found that the Freundlich and Temkin isotherm models fitted well the phenol adsorption on the activated carbon and that the adsorption process is favorable. The Langmuir equilibrium isotherm provides a maximum adsorption of 156.26 mg.g−1 at 20 °C. The pseudo-first-order, pseudo-second-order, intraparticle diffusion, and Boyd models were used to fit the kinetic data. The adsorption kinetics data were well described by the pseudo-second-order model. The kinetic was controlled by the external diffusion by macropore and mesopore, as well as by the micropore diffusion. The thermodynamic study revealed the exothermic and spontaneous nature of phenol adsorption on activated carbon with increased randomness at the solid-solution interface. On the other hand, a very large model based on the optimization parameters of phenol adsorption using k-nearest neighbor coupled with the gray wolf optimizer algorithm was launched to predict the amount of phenol adsorption. The KNN_GWO model showed an advantage in giving more precise values related to very high statistical coefficients (R = 0.9999, R2 = 0.9998 and R2adj = 0.9998) and very low statistical errors (RMSE = 0, 0070, MSE = 0.2347 and MAE = 0.2763). These advantages show the efficiency and performance of the model used

Designing a single-arm phase 2 clinical trial of mitapivat for adult patients with erythrocyte membranopathies (SATISFY): a framework for interventional trials in rare anaemias - pilot study protocol

Introduction Membranopathies encompass haemolytic disorders arising from genetic variants in erythrocyte membrane proteins, including hereditary spherocytosis and stomatocytosis. Congenital dyserythropoietic anaemia type II (CDA II) is associated with the SEC23B gene and can exhibit phenotypic similarities to membranopathies. Current treatment options for these conditions, apart from splenectomy, are primarily supportive. Mitapivat, a novel pyruvate kinase (PK) activator, has demonstrated efficacy in increasing haemoglobin levels and reducing haemolysis in patients with PK deficiency, thalassemia, sickle cell disease and a mouse model of hereditary spherocytosis. Methods and analyses Safety and efficacy of mitapivat sulfate in adult patients with erythrocyte membranopathies (SATISFY) is a prospective, multicentre, single-arm phase two trial involving approximately 25 adult patients (≥18 years) diagnosed with a membranopathy or CDA II. During the 8-week dose escalation period, subjects will receive an initial dose of 50 mg mitapivat two times per day and may increase to 100 mg two times per day at week 4 based on the safety and changes in haemoglobin levels. Patients tolerating mitapivat well may be eligible to continue in two consecutive 24-week fixed dose periods. The primary objective of this study is to evaluate the safety of mitapivat, assessed through the occurrence of treatment-emergent adverse events. Secondary objectives include assessing the effects of mitapivat on haemoglobin levels, haemolysis, erythropoiesis, patient-reported outcome measures and spleen size. SATISFY aims to assess the safety and efficacy of mitapivat in adult patients with red blood cell membranopathies and CDA II, with the aim of establishing proof-of-concept in patients living with these rare conditions

Characteristics and outcome of patients with low-/intermediate-risk acute promyelocytic leukemia treated with arsenic trioxide - an international collaborative study

The aim of this study was to characterize a large series of 154 patients with acute promyelocytic leukemia (APL; median age, 53 years; range, 18-90 years) and evaluate real-life outcome after up-front treatment with arsenic trioxide (ATO) and alltrans retinoic acid (ATRA). All patients were included in the prospective NAPOLEON registry (NCT02192619) between 2013 and 2019. APL was de novo in 91% (n=140) and therapy-related in 9% (n=14); 13% (n=20) were older than 70 years. At diagnosis bleeding/hemorrhage was present in 38% and thrombosis in 3%. Complete remission was achieved in 152 patients (99%), whereas two patients (1%) experienced induction death within 18 days after start of therapy. With a median follow-up of 1.99 years (95%-CI, 1.61-2.30 years) 1-year and 2-years overall survival (OS) rates were 97% (95%-CI, 94-100%) and 95% (95%-CI, 91-99%), respectively. Age above 70 years was associated with a significantly shorter OS (P<0.001) as compared to younger patients. So far no relapses were observed. Six patients (4%) died in CR after in median 0.95 years after diagnosis (range, 0.18-2.38 years). Our data confirm the efficiency and durability of ATO/ATRA in the primary management of adult low-/ intermediate-risk APL patients in the real life setting, irrespective of age

Étude des lichens saxicoles de la steppe semi-aride de Djebel Zdimm (Nord-Est de l’Algérie)

Dans les hautes plaines setifiennes, la roche calcaire, composante principale de Djebel Zdimm, a contribué à l’installation d’une végétation lichénique saxicole très diversifiée et qui présente un très grand intérêt biologique et phytogéographique, en raison de sa présence dans une steppe semi-aride avec une saison sèche prolongée sur plus de cinq mois. L’élaboration d’une première liste de lichens pour Djebel Zdimm nous a permis de recenser 55 espèces saxicoles identifiées et signalées pour la première fois dans un écosystème steppique dont 5 sont nouveaux pour l’Algérie : Acarospora nitrophila H. Magn., Myriolecis invadens (H. Magn.) Śliwa, Zhao Xin et Lumbsch, Melanelia stygia (L.) Essl, Squamarina concrescens (Müll. Arg.) Poelt et Verrucaria sphaerospora Anzi. Cette étude participe non seulement à compléter les connaissances lacunaires sur la flore lichénique de l’Algérie, mais aussi à la conservation et la protection de la diversité biologique de cet écosystème steppique face aux changements climatiques.In the high plains of setif, calcareous rock, the main component of Djebel Zdimm, has contributed to the installation of very diverse saxicolous lichenic vegetation which is of great biological and phytogeographic interest because of its presence in a semi-arid steppe with a dry season extended for more than five months. The elaboration of a first list of lichens of Djebel Zdimm allowed us to identify 55 saxicolous species identified and reported for the first time in a steppe ecosystem, 5 of which are new to Algeria : Acarospora nitrophila H. Magn., Myriolecis invadens (H. Magn.) Śliwa, Zhao Xin et Lumbsch, Melanelia stygia (L.) Essl, Squamarina concrescens (Müll. Arg.) Poelt et Verrucaria sphaerospora Anzi. This study not only contributes to complete the lack of knowledge about the lichen flora of Algeria but also to the conservation and protection of the biological diversity of this steppe ecosystem in the face of climate change