201 research outputs found
MiR-126 enhances cisplatin chemosensitivity in hepatocellular carcinoma cells by targeting IRS1
Purpose: To investigate the potential role of miR-126 in regulating the proliferation and cisplatin chemosensitivity of human hepatocellular carcinoma (HCC) cells.Methods: The expression of miR-126 was evaluated using clinical HCC specimens. MiR-126-mediated downregulation of Insulin Receptor Substrate 1 (IRS1) was determined by qRT-PCR, western blot and luciferase reporter assay. Cell Counting Kit-8 (CCK8) and colony formation assays were performed to examine the proliferation of HCC cells.Results: Decreased expression of miR126 was found in HCC tumors and was correlated with poor survival in HCC patients. In HCC cells, miR-126 targeted IRS1 for downregulation, through which miR- 126 suppressed the growth of HCC cells and desensitized HCC cells to cisplatin treatment.Conclusion: MiR-126a impairs the proliferation and cisplatin chemoresistance of HCC cells by targeting IRS1.Keywords: miR-126, IRS1, HCC, cisplatin, chemosensitivit
Generative Adversarial Mapping Networks
Generative Adversarial Networks (GANs) have shown impressive performance in
generating photo-realistic images. They fit generative models by minimizing
certain distance measure between the real image distribution and the generated
data distribution. Several distance measures have been used, such as
Jensen-Shannon divergence, -divergence, and Wasserstein distance, and
choosing an appropriate distance measure is very important for training the
generative network. In this paper, we choose to use the maximum mean
discrepancy (MMD) as the distance metric, which has several nice theoretical
guarantees. In fact, generative moment matching network (GMMN) (Li, Swersky,
and Zemel 2015) is such a generative model which contains only one generator
network trained by directly minimizing MMD between the real and generated
distributions. However, it fails to generate meaningful samples on challenging
benchmark datasets, such as CIFAR-10 and LSUN. To improve on GMMN, we propose
to add an extra network , called mapper. maps both real data
distribution and generated data distribution from the original data space to a
feature representation space , and it is trained to maximize MMD
between the two mapped distributions in , while the generator
tries to minimize the MMD. We call the new model generative adversarial mapping
networks (GAMNs). We demonstrate that the adversarial mapper can help
to better capture the underlying data distribution. We also show that GAMN
significantly outperforms GMMN, and is also superior to or comparable with
other state-of-the-art GAN based methods on MNIST, CIFAR-10 and LSUN-Bedrooms
datasets.Comment: 9 pages, 7 figure
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