Cardiac dysfunction associated with consumptive hypothyroidism in a case of hepatic haemangioma

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Case Report: Identification of a novel LYN::LINC01900 transcript with promyelocytic phenotype and TP53 mutation in acute myeloid leukemia

Acute myeloid leukemia (AML) is a malignant disease of myeloid hematopoietic stem/progenitor cells characterized by the abnormal proliferation of primitive and naive random cells in the bone marrow and peripheral blood. Acute promyelocytic leukemia (APL) is a type (AML-M3) of AML. Most patients with APL have the characteristic chromosomal translocation t(15; 17)(q22; q12), forming PML::RARA fusion. The occurrence and progression of AML are often accompanied by the emergence of gene fusions such as PML::RARA, CBFβ::MYH11, and RUNX1::RUNX1T1, among others. Gene fusions are the main molecular biological abnormalities in acute leukemia, and all fusion genes act as crucial oncogenic factors in leukemia. Herein, we report the first case of LYN::LINC01900 fusion transcript in AML with a promyelocytic phenotype and TP53 mutation. Further studies should address whether new protein products may result from this fusion, as well as the biological function of these new products in disease occurrence and progression

Thermal Performance Analysis on the Seasonal Heat Storage by Deep Borehole Heat Exchanger with the Extended Finite Line Source Model

Deep borehole heat exchanger is promising and competitive for seasonal heat storage in the limited space underground with great efficiency. However, seasonal heat storage performance of the essentially deep borehole heat exchanger reaching kilometers underground was seldom studied. In addition, previous research rarely achieved comprehensive assessment for its thermal performance due to seasonal heat storage. Insight into the complicated heat transfer characteristics during the whole process of prior charging and subsequent discharging of deep borehole heat exchanger is in urgent need to be clarified. To this end, an extended finite line source model is proposed to investigate thermal performance of the deep borehole heat exchanger during charging and discharging stages. It is developed with modifications of classical finite line source model to consider the spatio-temporally non-uniform distribution of heat flux density and anisotropic thermal conductivity of deep rock. In general, simulation results demonstrate that thermal performance of the deep borehole heat exchanger deteriorates rapidly both during charging and discharging stages, making it impossible to sustain long-term efficient operation. Specifically, it was discovered that low temperature heat storage utilized only upper section of the borehole as effective heat storage section, and enhancement for heat extraction potential during the heating season was not significant. While high temperature heat storage by deep borehole heat exchanger could only enhance the heat extraction potential for 30 to 40 days in the initial stage of heating. Throughout the discharging, maximum thermal performance enhancement up to 11.27 times was achieved and the heat storage efficiency was evaluated at 2.86 based on average heat exchange rate. The findings of this study are intended to provide a guidance for decisionmakers to determine the most suitable seasonal heat storage strategy for the deep borehole heat exchanger and facilitate the application in engineering practice

Daily Peer Relationships and Academic Achievement among College Students: A Social Network Analysis Based on Behavioral Big Data

This study aimed to detect college students’ daily peer networks through a behavioral big-data-driven social network analysis and to explore the relationship between college students’ daily peer relationships and academic achievement. We collected data on the class attendance, eating, and bathing records of 4738 undergraduate students who entered a university in 2018 to infer the daily peer relationship networks of students. The Louvain algorithm and some network indicators such as density and average clustering coefficient were used to investigate social network characteristics of peer relationship networks. The findings show that initially, students in the same dormitory tended to form daily peer relationships, gradually shifting toward relationships centered on classmates as time progressed. These peer networks often aligned with geographical location and living areas. Moreover, the peers of college students who received high-level scholarships were more likely to receive scholarships. The number of peers was positively correlated with the likelihood of receiving a scholarship. The research findings contribute to the application of information technology to promote the sustainable development of higher education and individual students

Rietveld refinement of Ba-5(AsO4)(3)Cl from high-resolution synchrotron data

The apatite-type compound Ba5(AsO4)3Cl, penta­barium tris­[arsenate(V)] chloride, has been synthesized by ion exchange at high temperature from a synthetic sample of mimetite (Pb5(AsO4)3Cl) with BaCO3 as a by-product. The results of the Rietveld refinement, based on high resolution synchrotron X-ray powder diffraction data, show that the title compound crystallizes in the same structure as other halogenoapatites with general formula A 5(YO4)3 X (A = divalent cation, Y = penta­valent cation, X = Cl, Br) in space group P63/m. The structure consists of isolated tetra­hedral AsO4 3− anions (m symmetry), separated by two crystallographically independent Ba2+ cations that are located on mirror planes and threefold rotation axes, respectively. The Cl− anions are at the 2b sites ( symmetry) and are located in the channels of the structure

Lactic acid bacteria differentially regulate filamentation in two heritable cell types of the human fungal pathogen Candida albicans

Microorganisms rarely exist as single species in natural environments. The opportunistic fungal pathogen Candida albicans and lactic acid bacteria (LAB) are common members of the microbiota of several human niches such as the mouth, gut and vagina. Lactic acid bacteria are known to suppress filamentation, a key virulence feature of C. albicans, through the production of lactic acid and other metabolites. Here we report that C. albicans cells switch between two heritable cell types, white and opaque, to undergo filamentation to adapt to diversified environments. We show that acidic pH conditions caused by LAB and low temperatures support opaque cell filamentation, while neutral pH conditions and high temperatures promote white cell filamentation. The cAMP signalling pathway and the Rfg1 transcription factor play major roles in regulating the responses to these conditions. This cell type-specific response of C. albicans to different environmental conditions reflects its elaborate regulatory control of phenotypic plasticity

Idiopathic Pulmonary Fibrosis Registry China study (PORTRAY): protocol for a prospective, multicentre registry study

Introduction Idiopathic pulmonary fibrosis (IPF) is a progressive and lethal lung disease characterised by a fibrotic histological pattern found in usual interstitial pneumonia. Its causes, pathogenesis, clinical phenotype and molecular mechanisms are poorly defined. Large-scale, multicentre studies are warranted to better understand IPF as a disease in China, its associated risk factors, clinical characteristics, diagnosis, disease progression and treatment.Methods and analysis The Idiopathic Pulmonary Fibrosis Registry China Study (PORTRAY) is a prospective, multicentre registry study of patients with IPF in China. Eight hundred patients will be enrolled over a 36-month period and followed for at least 3 years to generate a comprehensive database on baseline characteristics and various follow-up parameters including patient-reported outcomes. Biological specimens will also be collected from patients to develop a library of blood, bronchoalveolar lavage fluid and lung biopsy samples, to support future research. As of 15 December 2019, 204 patients from 19 large medical centres with relatively high IPF diagnosis and treatment rates had been enrolled. Patient characteristics will be presented using descriptive statistics. The Kaplan-Meier method will be used for survival analyses. Repeated measures will be used to compare longitudinal changes in lung function, imaging and laboratory tests. Results following analysis have been projected to be available by July 2025.Ethics and dissemination The study protocol was reviewed and approved by the Institutional Review Board from all the study sites currently recruiting patients. Study results will be published in peer-reviewed journals.Trial registration number NCT03666234

The recent history of hydro-geomorphological processes in the upper Hangbu river system, Anhui Province, China

This paper describes 20th century climate and human impacts on terrestrial and fluvial systems in the Dabie Mountains, Anhui Province, China, based on analyses of four types of information. Analyses of particle size,mineral magnetism, organic carbon, nitrogen and phosphorus in a sediment core taken from the Longhekou reservoir, built in 1958 AD in the upper reaches of Hangbu River, provide an ?45 year record of fluvial responses, while monitored meteorological and hydrological data provide records of climate and river discharge. Census data compiled for the local Shucheng County provide records of population and land use,complemented with analyses of satellite images. The Xiaotian river delivers over 65% of the total water and silt to the reservoir. Analyses indicate that the fluvial regime tracks the monsoon climate over seasonal timescales, but human activities have a strongly mediating effect on sediment supply, sediment delivery and, to a lesser extent, runoff over longer timescales. Notable periods of human impact on erosion include the Great Leap Forward (1958–1960) and Great Cultural Revolution (1966–1976). A rising trend in precipitation and new land use changes at the present time may be leading to an enhanced flood risk

Discovery of a "white-gray-opaque" tristable phenotypic switching system in candida albicans: roles of non-genetic diversity in host adaptation.

Non-genetic phenotypic variations play a critical role in the adaption to environmental changes in microbial organisms. Candida albicans, a major human fungal pathogen, can switch between several morphological phenotypes. This ability is critical for its commensal lifestyle and for its ability to cause infections. Here, we report the discovery of a novel morphological form in C. albicans, referred to as the "gray" phenotype, which forms a tristable phenotypic switching system with the previously reported white and opaque phenotypes. White, gray, and opaque cell types differ in a number of aspects including cellular and colony appearances, mating competency, secreted aspartyl proteinase (Sap) activities, and virulence. Of the three cell types, gray cells exhibit the highest Sap activity and the highest ability to cause cutaneous infections. The three phenotypes form a tristable phenotypic switching system, which is independent of the regulation of the mating type locus (MTL). Gray cells mate over 1,000 times more efficiently than do white cells, but less efficiently than do opaque cells. We further demonstrate that the master regulator of white-opaque switching, Wor1, is essential for opaque cell formation, but is not required for white-gray transitions. The Efg1 regulator is required for maintenance of the white phenotype, but is not required for gray-opaque transitions. Interestingly, the wor1/wor1 efg1/efg1 double mutant is locked in the gray phenotype, suggesting that Wor1 and Efg1 could function coordinately and play a central role in the regulation of gray cell formation. Global transcriptional analysis indicates that white, gray, and opaque cells exhibit distinct gene expression profiles, which partly explain their differences in causing infections, adaptation ability to diverse host niches, metabolic profiles, and stress responses. Therefore, the white-gray-opaque tristable phenotypic switching system in C. albicans may play a significant role in a wide range of biological aspects in this common commensal and pathogenic fungus