8 research outputs found
Detection of SARS Coronavirus in Patients with Suspected SARS
Cases of severe acute respiratory syndrome (SARS) were investigated for SARS coronavirus (SARS-CoV) through RNA tests, serologic response, and viral culture. Of 537 specimens from patients in whom SARS was clinically diagnosed, 332 (60%) had SARS-CoV RNA in one or more clinical specimens, compared with 1 (0.3%) of 332 samples from controls. Of 417 patients with clinical SARS from whom paired serum samples were available, 92% had an antibody response. Rates of viral RNA positivity increased progressively and peaked at day 11 after onset of illness. Although viral RNA remained detectable in respiratory secretions and stool and urine specimens for >30 days in some patients, virus could not be cultured after week 3 of illness. Nasopharyngeal aspirates, throat swabs, or sputum samples were the most useful clinical specimens in the first 5 days of illness, but later in the illness viral RNA could be detected more readily in stool specimens
Viral Loads in Clinical Specimens and SARS Manifestations
The number of anatomical sites with detectable viral loads by RT-qPCR appeared to correlate with death risk
Lymphopenia at presentation is associated with increased risk of infections in patients with systemic lupus erythematosus
Detection of norovirus in air samples in a non-vomiting patient: implications of testing saliva for norovirus in an immunocompromised host
High prevalence of primary Enfuvirtide (ENF) resistance-associated mutations in HIV-1-infected patients in Hong Kong
Respiratory virus infection among hospitalized adult patients with or without clinically apparent respiratory infection: a prospective cohort study
COVID-19: Morphology, Characteristics, Symptoms, Prevention, Clinical Diagnosis and Current Scenario
Not sick enough to worry? "Influenza-like" symptoms and work-related behavior among healthcare workers and other professionals: Results of a global survey
10.1371/journal.pone.0232168PLoS ONE155e023216