1,535 research outputs found
A decade in review after Idiopathic Scoliosis was first called a complex trait-A tribute to the late Dr. Yves Cotrel for his support in studies of etiology of scoliosis
Adolescent Idiopathic Scoliosis (AIS) is a prevalent and important spine disorder in the pediatric age group. An increased family tendency was observed for a long time, but the underlying genetic mechanism was uncertain. In 1999, Dr. Yves Cotrel founded the Cotrel Foundation in the Institut de France, which supported collaboration of international researchers to work together to better understand the etiology of AIS. This new concept of AIS as a complex trait evolved in this setting among researchers who joined the annual Cotrel meetings. It is now over a decade since the first proposal of the complex trait genetic model for AIS. Here, we review in detail the vast information about the genetic and environmental factors in AIS pathogenesis gathered to date. More importantly, new insights into AIS etiology were brought to us through new research data under the perspective of a complex trait. Hopefully, future research directions may lead to better management of AIS, which has a tremendous impact on affected adolescents in terms of both physical growth and psychological development
A decade in review after Idiopathic Scoliosis was first called a complex trait-A tribute to the late Dr. Yves Cotrel for his support in studies of etiology of scoliosis
Adolescent Idiopathic Scoliosis (AIS) is a prevalent and important spine disorder in the pediatric age group. An increased family tendency was observed for a long time, but the underlying genetic mechanism was uncertain. In 1999, Dr. Yves Cotrel founded the Cotrel Foundation in the Institut de France, which supported collaboration of international researchers to work together to better understand the etiology of AIS. This new concept of AIS as a complex trait evolved in this setting among researchers who joined the annual Cotrel meetings. It is now over a decade since the first proposal of the complex trait genetic model for AIS. Here, we review in detail the vast information about the genetic and environmental factors in AIS pathogenesis gathered to date. More importantly, new insights into AIS etiology were brought to us through new research data under the perspective of a complex trait. Hopefully, future research directions may lead to better management of AIS, which has a tremendous impact on affected adolescents in terms of both physical growth and psychological development
Neutrix Calculus and Finite Quantum Field Theory
In general, quantum field theories (QFT) require regularizations and infinite
renormalizations due to ultraviolet divergences in their loop calculations.
Furthermore, perturbation series in theories like QED are not convergent
series, but are asymptotic series. We apply neutrix calculus, developed in
connection with asymptotic series and divergent integrals, to QFT,obtaining
finite renormalizations. While none of the physically measurable results in
renormalizable QFT is changed, quantum gravity is rendered more manageable in
the neutrix framework.Comment: 10 pages; LaTeX; version to appear in J. Phys. A: Math. Gen. as a
Letter to the Edito
Dimensionless supersymmetry breaking couplings, flat directions, and the origin of intermediate mass scales
The effects of supersymmetry breaking are usually parameterized by soft
couplings of positive mass dimensions. However, realistic models also predict
the existence of suppressed, but non-vanishing, dimensionless
supersymmetry-breaking couplings. These couplings are technically hard, but do
not lead to disastrous quadratic divergences in scalar masses, and may be
crucial for understanding low-energy physics. In particular, analytic scalar
quartic couplings that break supersymmetry can lead to intermediate scale
vacuum expectation values along nearly-flat directions. I study the one-loop
effective potential for flat directions in the presence of dimensionless
supersymmetry-breaking terms, and discuss the corresponding renormalization
group equations. I discuss two applications: a minimal model of automatic
R-parity conservation, and an extension of this minimal model which provides a
solution to the \mu problem and an invisible axion.Comment: 28 pages, LaTeX with epsf and axodraw.st
Multi-scale modeling study of the source contributions to near-surface ozone and sulfur oxides levels over California during the ARCTAS-CARB period
Chronic high surface ozone (O3) levels and the increasing sulfur oxides (SOx = SO2+SO4) ambient concentrations over South Coast (SC) and other areas of California (CA) are affected by both local emissions and long-range transport. In this paper, multi-scale tracer, full-chemistry and adjoint simulations using the STEM atmospheric chemistry model are conducted to assess the contribution of local emission sourcesto SC O3 and to evaluate the impacts of transported sulfur and local emissions on the SC sulfur budgetduring the ARCTAS-CARB experiment period in 2008. Sensitivity simulations quantify contributions of biogenic and fire emissions to SC O3 levels. California biogenic and fire emissions contribute 3â4 ppb to near-surface O3 over SC, with larger contributions to other regions in CA. During a long-range transport event from Asia starting from 22 June, high SOx levels (up to ~0.7 ppb of SO2 and ~1.3 ppb of SO4) is observed above ~6 km, but they did not affect CA surface air quality. The elevated SOx observed at 1â4 km is estimated to enhance surface SOx over SC by ~0.25 ppb (upper limit) on ~24 June. The near-surface SOx levels over SC during the flight week are attributed mostly to local emissions. Two anthropogenic SOx emission inventories (EIs) from the California Air Resources Board (CARB) and the US Environmental Protection Agency (EPA) are compared and applied in 60 km and 12 km chemical transport simulations, and the results are compared withobservations. The CARB EI shows improvements over the National Emission Inventory (NEI) by EPA, but generally underestimates surface SC SOx by about a factor of two. Adjoint sensitivity analysis indicated that SO2 levels at 00:00 UTC (17:00 local time) at six SC surface sites were influenced by previous day maritime emissions over the ocean, the terrestrial emissions over nearby urban areas, and by transported SO2 from the north through both terrestrial and maritime areas. Overall maritime emissions contribute 10â70% of SO2 and 20â60% fine SO4 on-shore and over the most terrestrial areas, with contributions decreasing with in-land distance from the coast. Maritime emissions also modify the photochemical environment, shifting O3 production over coastal SC to more VOC-limited conditions. These suggest an important role for shipping emission controls in reducing fine particle and O3concentrations in SC
Sfermion masses in Nelson-Strassler type of models: SUSY standard models coupled with SCFTs
We study soft SUSY breaking parameters in the Nelson-Strassler type of
models: SUSY standard models coupled with SCFTs. In this type of models, soft
SUSY breaking parameters including sfermion masses can be suppressed around the
decoupling scale of SCFTs. We clarify the condition to derive exponential
suppression of sfermion masses within the framework of pure SCFTs. Such
behavior is favorable for degeneracy of sfermion masses. However, the realistic
sfermion masses are not quite degenerate due to the gauge couplings and the
gaugino masses in the SM sector. We show the sfermion mass spectrum obtained in
such models. The aspect of suppression for the soft SUSY breaking parameters is
also demonstrated in an explicit model. We also give a mechanism generating the
-term of the Electro-Weak scale by a singlet field coupled with the SCFT.Comment: 28 pages, 8 figures, LaTeX file; corrected typos and references adde
Unification through extra dimensions at two loops
The presence of an extra dimension of size R\equiv M_c^{-1} introduces
corrections of order (\mu/M_c)\alpha to the gauge and Yukawa couplings and
accelerates their running at scales \mu larger than M_c. This could result in a
grand unification scale M_X\approx 20 M_c. We study the corrections at the
two-loop level. We find corrections of order (\mu/M_c)\alpha^2 for the gauge
couplings and of order (\mu/M_c)^2\alpha^2 for the Yukawa couplings. Therefore,
in the Yukawa sector one and two-loop contributions can be of the same order
below M_X. We show that in the usual scenarios the dominant gauge and Yukawa
couplings are decreasing functions of the scale, in such a way that
(\mu/M_c)\alpha becomes approximately constant and two-loop contributions
introduce just a 30% correction which does not increase with the scale.Comment: 14 pages, added references, corrected typo
The Minimal Supersymmetric Fat Higgs Model
We present a calculable supersymmetric theory of a composite ``fat'' Higgs
boson. Electroweak symmetry is broken dynamically through a new gauge
interaction that becomes strong at an intermediate scale. The Higgs mass can
easily be 200-450 GeV along with the superpartner masses, solving the
supersymmetric little hierarchy problem. We explicitly verify that the model is
consistent with precision electroweak data without fine-tuning. Gauge coupling
unification can be maintained despite the inherently strong dynamics involved
in electroweak symmetry breaking. Supersymmetrizing the Standard Model
therefore does not imply a light Higgs mass, contrary to the lore in the
literature. The Higgs sector of the minimal Fat Higgs model has a mass spectrum
that is distinctly different from the Minimal Supersymmetric Standard Model.Comment: 13 pages, 5 figures, REVTe
Phenomenology of flavor-mediated supersymmetry breaking
The phenomenology of a new economical SUSY model that utilizes dynamical SUSY
breaking and gauge-mediation (GM) for the generation of the sparticle spectrum
and the hierarchy of fermion masses is discussed. Similarities between the
communication of SUSY breaking through a messenger sector, and the generation
of flavor using the Froggatt-Nielsen (FN) mechanism are exploited, leading to
the identification of vector-like messenger fields with FN fields, and the
messenger U(1) as a flavor symmetry. An immediate consequence is that the first
and second generation scalars acquire flavor-dependent masses, but do not
violate FCNC bounds since their mass scale, consistent with effective SUSY, is
of order 10 TeV. We define and advocate a minimal flavor-mediated model (MFMM),
recently introduced in the literature, that successfully accommodates the small
flavor-breaking parameters of the standard model using order one couplings and
ratios of flavon field vevs. The mediation of SUSY breaking occurs via two-loop
log-enhanced GM contributions, as well as several one-loop and two-loop
Yukawa-mediated contributions for which we provide analytical expressions. The
MFMM is parameterized by a small set of masses and couplings, with values
restricted by several model constraints and experimental data. The
next-to-lightest sparticle (NLSP) always has a decay length that is larger than
the scale of a detector, and is either the lightest stau or the lightest
neutralino. Similar to ordinary GM models, the best collider search strategies
are, respectively, inclusive production of at least one highly ionizing track,
or events with many taus plus missing energy. In addition, D^0 - \bar{D}^0
mixing is also a generic low energy signal. Finally, the dynamical generation
of the neutrino masses is briefly discussed.Comment: 54 pages, LaTeX, 8 figure
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