Morphology of Novel Chitosan Oligosaccharides Mod-ified Cross-linked Polyvinyl Alcohol Complex Foam (COS/cPVACF) Dressings with Fully Open-cell and Open-channel Microstructures via Active Molecules Cleaning Process for Wound Managements

The design of medical devices could be applied and developed for new treatment proce-dures instead of the traditional therapy procedures

A Systematic RNAi Screen Reveals a Novel Role of a Spindle Assembly Checkpoint Protein BuGZ in Synaptic Transmission in C. elegans

Synaptic vesicles (SV) store various neurotransmitters that are released at the synapse. The molecular mechanisms of biogenesis, exocytosis, and endocytosis for SV, however, remain largely elusive. In this study, using Complex Object Parametric Analysis and Sorter (COPAS) to monitor the fluorescence of synapto-pHluorin (SpH), we performed a whole-genome RNAi screen in C. elegans to identify novel genetic modulators in SV cycling. One hundred seventy six genes that up-regulating SpH fluorescence and 96 genes that down-regulating SpH fluorescence were identified after multi-round screen. Among these genes, B0035.1 (bugz-1) encodes ortholog of mammalian C2H2 zinc-finger protein BuGZ/ZNF207, which is a spindle assembly checkpoint protein essential for mitosis in human cells. Combining electrophysiology, imaging and behavioral assays, we reveal that depletion of BuGZ-1 results in defects in locomotion. We further demonstrate that BuGZ-1 promotes SV recycling by regulating the expression levels of endocytosis-related genes such as rab11.1. Therefore, we have identified a bunch of potential genetic modulators in SV cycling, and revealed an unexpected role of BuGZ-1 in regulating synaptic transmission

Preclinical evaluation of designed extra permeable anti-adhesion protecting membranes with low residual formaldehyde contents via active molecules cleaning process for diabetic foot ulcer wound management

Image appears to be a fallen monumenthttps://egrove.olemiss.edu/rayburn/1054/thumbnail.jp

Evaluating Social Media Response to Urban Flood Disaster: Case Study on an East Asian City (Wuhan, China)

Social media is an important tool for disaster prevention and management. To reveal the public responses to disasters on social media in the context of East Asian culture, an urban flood disaster event that occurred in Wuhan City, China, in the summer of 2016 was selected as a case. Data were collected from Sina-Weibo, which is the earliest and most popular social media platform in China. We categorized a total of 17,047 messages into four types, analyzed the Pearson correlation between information dissemination and precipitation, and identified the important accounts and their messages in the social networks by visualized analysis. The results show that there is a one-day lag between participation and public response. Message dissemination has a steeply downward trend over time, that is, a long tail effect. Information disseminates quickly within two hours, and then dissemination declines after four hours, with opinion messages disseminating faster than other types of messages. Famous news organizations and several celebrities play a leading role in social networks. In general, the participation of Chinese netizens in disaster events is lower than that of people in Western countries, and social media is not yet used as a tool for disaster response