Distribution logistics of online fashion retail business in China: A case study of VANCL

The rapid development of information technologies brings more convenience to people. Information technologies, especially the Internet, not only save time for consumers and companies but also provide them with more channels and opportunities for interaction and conducting transactions. One business revolution brought by Internet is online shopping – shopping and buying products in online stores or websites. Nowadays, online shopping has become a new consuming model for consumers both in China and around the world. This paper analyses online shopping for fashion in China and investigates the impact of online shopping on logistics industry using the case of “VANCL”

Lost in Translation -- Multilingual Misinformation and its Evolution

Misinformation and disinformation are growing threats in the digital age, spreading rapidly across languages and borders. This paper investigates the prevalence and dynamics of multilingual misinformation through an analysis of over 250,000 unique fact-checks spanning 95 languages. First, we find that while the majority of misinformation claims are only fact-checked once, 11.7%, corresponding to more than 21,000 claims, are checked multiple times. Using fact-checks as a proxy for the spread of misinformation, we find 33% of repeated claims cross linguistic boundaries, suggesting that some misinformation permeates language barriers. However, spreading patterns exhibit strong homophily, with misinformation more likely to spread within the same language. To study the evolution of claims over time and mutations across languages, we represent fact-checks with multilingual sentence embeddings and cluster semantically similar claims. We analyze the connected components and shortest paths connecting different versions of a claim finding that claims gradually drift over time and undergo greater alteration when traversing languages. Overall, this novel investigation of multilingual misinformation provides key insights. It quantifies redundant fact-checking efforts, establishes that some claims diffuse across languages, measures linguistic homophily, and models the temporal and cross-lingual evolution of claims. The findings advocate for expanded information sharing between fact-checkers globally while underscoring the importance of localized verification

Lost in Translation--Multilingual Misinformation and its Evolution

Misinformation and disinformation are growing threats in the digital age, spreading rapidly across languages and borders. This paper investigates the prevalence and dynamics of multilingual misinformation through an analysis of over 250,000 unique fact-checks spanning 95 languages. First, we find that while the majority of misinformation claims are only fact-checked once, 11.7%, corresponding to more than 21,000 claims, are checked multiple times. Using fact-checks as a proxy for the spread of misinformation, we find 33% of repeated claims cross linguistic boundaries, suggesting that some misinformation permeates language barriers. However, spreading patterns exhibit strong homophily, with misinformation more likely to spread within the same language. To study the evolution of claims over time and mutations across languages, we represent fact-checks with multilingual sentence embeddings and cluster semantically similar claims. We analyze the connected components and shortest paths connecting different versions of a claim finding that claims gradually drift over time and undergo greater alteration when traversing languages. Overall, this novel investigation of multilingual misinformation provides key insights. It quantifies redundant fact-checking efforts, establishes that some claims diffuse across languages, measures linguistic homophily, and models the temporal and cross-lingual evolution of claims. The findings advocate for expanded information sharing between fact-checkers globally while underscoring the importance of localized verification

Subcellular Targeting Domains of Sphingomyelin Synthase 1 and 2

Sphingomyelin synthase (SMS) sits at the crossroads of sphingomyelin (SM), ceramide, diacylglycerol (DAG) metabolism. It utilizes ceramide and phosphatidylcholine as substrates to produce SM and DAG, thereby regulating lipid messengers which play a role in cell survival and apoptosis. Furthermore, its product SM has been implicated in atherogenic processes such as retention of lipoproteins in the blood vessel intima. There are two mammalian sphingomyelin synthases: SMS1 and SMS2. SMS1 is found exclusively in the Golgi at steady state, whereas SMS2 exists in the Golgi and plasma membrane. Conventional motifs responsible for protein targeting to the plasma membrane or Golgi are either not present in, or unique to, SMS1 and SMS2. In this study, we examined how SMS1 and SMS2 achieve their respective subcellular localization patterns. Brefeldin A treatment prevented SMS1 and SMS2 from exiting the ER, demonstrating that they transit through the classical secretory pathway. We created truncations and chimeras of SMS1 and SMS2 to define their targeting signals. We found that SMS1 contains a C-terminal Golgi targeting signal and that SMS2 contains a C-terminal plasma membrane targeting signal

Calibration of Parshall Flumes with Non-Standard Entrance Transitions

The 9-ince and 18-inch Parshall flumes with the throat section installed level with the bottom of an incoming pipe were tested. The measured discharges for given flow depths (free flow) or differences in flow depths (submerged flow) were found to deviate quite significantly fromt he computed standard Parshall flume disharges at both low and high flow rates. New empirical formulats have been developed to take such deviations into account. It is noted that values of the coefficients and exponents contained in the new formulas depend on the throat size of the flume and the slope of the incoming pipe. Calibration curves and tables were prepared for convenient applications of the new formulas

Relationship between cortical thickness and neuropsychological performance in normal older adults and those with mild cognitive impairment

Mild cognitive impairment (MCI) has been extensively investigated in recent decades to identify groups with a high risk of dementia and to establish effective prevention methods during this period. Neuropsychological performance and cortical thickness are two important biomarkers used to predict progression from MCI to dementia. This study compares the cortical thickness and neuropsychological performance in people with MCI and cognitively healthy older adults. We further focus on the relationship between cortical thickness and neuropsychological performance in these two groups. Forty-nine participants with MCI and 40 cognitively healthy older adults were recruited. Cortical thickness was analysed with semiautomatic software, Freesurfer. The analysis reveals that the cortical thickness in the left caudal anterior cingulate (p=0.041), lateral occipital (p=0.009) and right superior temporal (p=0.047) areas were significantly thinner in the MCI group after adjustment for age and education. Almost all neuropsychological test results (with the exception of forward digit span) were significantly correlated to cortical thickness in the MCI group after adjustment for age, gender and education. In contrast, only the score on the Category Verbal Fluency Test and the forward digit span were found to have significant inverse correlations to cortical thickness in the control group of cognitively healthy older adults. The study results suggest that cortical thinning in the temporal region reflects the global change in cognition in subjects with MCI and may be useful to predict progression of MCI to Alzheimer's disease. The different pattern in the correlation of cortical thickness to the neuropsychological performance of patients with MCI from the healthy control subjects may be explained by the hypothesis of MCI as a disconnection syndrome

A profile of the online dissemination of national influenza surveillance data

<p>Abstract</p> <p>Background</p> <p>Influenza surveillance systems provide important and timely information to health service providers on trends in the circulation of influenza virus and other upper respiratory tract infections. Online dissemination of surveillance data is useful for risk communication to health care professionals, the media and the general public. We reviewed national influenza surveillance websites from around the world to describe the main features of surveillance data dissemination.</p> <p>Methods</p> <p>We searched for national influenza surveillance websites for every country and reviewed the resulting sites where available during the period from November 2008 through February 2009. Literature about influenza surveillance was searched at MEDLINE for relevant hyperlinks to related websites. Non-English websites were translated into English using human translators or Google language tools.</p> <p>Results</p> <p>A total of 70 national influenza surveillance websites were identified. The percentage of developing countries with surveillance websites was lower than that of developed countries (22% versus 57% respectively). Most of the websites (74%) were in English or provided an English version. The most common surveillance methods included influenza-like illness consultation rates in primary care settings (89%) and laboratory surveillance (44%). Most websites (70%) provided data within a static report format and 66% of the websites provided data with at least weekly resolution.</p> <p>Conclusion</p> <p>Appropriate dissemination of surveillance data is important to maximize the utility of collected data. There may be room for improvement in the style and content of the dissemination of influenza data to health care professionals and the general public.</p

Would transcranial direct current stimulation (tDCS) enhance the effects of working memory training in older adults with mild neurocognitive disorder due to Alzheimer’s disease: study protocol for a randomized controlled trial

© 2015 Cheng et al. Background: There has been longstanding interesting in cognitive training for older adults with cognitive impairment. In this study, we will investigate the effects of working memory training, and explore augmentation strategies that could possibly consolidate the effects in older adults with mild neurocognitive disorder. Transcranial direct current stimulation (tDCS) has been demonstrated to affect the neuronal excitability and reported to enhance memory performance. As tDCS may also modulate cognitive function through changes in neuroplastic response, it would be adopted as an augmentation strategy for working memory training in the present study. Methods/Design: This is a 4-week intervention double-blind randomized controlled trial (RCT) of tDCS. Chinese older adults (aged 60 to 90 years) with mild neurocognitive disorder due to Alzheimer 's disease (DSM-5 criteria) would be randomized into a 4-week intervention of either tDCS-working memory (DCS-WM), tDCS-control cognitive training (DCS-CC), and sham tDCS-working memory (WM-CD) groups. The primary outcome would be working memory test - the n-back task performance and the Chinese version of the Alzheimer's Disease Assessment Scale - Cognitive Subscale (ADAS-Cog). Secondary outcomes would be test performance of specific cognitive domains and mood. Intention-to-treat analysis would be carried out. Changes of efficacy indicators with time and intervention would be tested with mixed effect models. Discussion: This study adopts the theory of neuroplasticity to evaluate the potential cognitive benefits of non-invasive electrical brain stimulation, working memory training and dual stimulation in older adults at risk of cognitive decline. It would also examine the tolerability, program adherence and adverse effects of this novel intervention. Information would be helpful for further research of dementia prevention studies. Trial registration: ChiCTR-TRC- 14005036Date of registration: 31 July 2014.published_or_final_versio