4′-Methyl-3-(4-nitro­phen­yl)-4-phenyl-4,5,1′,2′,3′,4′-hexa­hydro­spiro­[isoxazole-5,2′-naphthalen]-1′-one

The title compound, C25H20N2O4, is a new spiro-isoxazoline derivative. It contains a five-membered isoxazoline ring (A), a tetra­lone unit (E and D), a 4-nitro­phenyl substituent (B), and a phenyl ring (C). The isoxazoline ring (A) has an envelope conformation, while the cyclo­hexenone ring (D) has an inter­mediate sofa/half-chair conformation. The aromatic ring of the 4-nitro­phenyl substituent (B) is inclined at an angle of 78.97 (10)° to the phenyl ring (C). The rigid pharmacophore site, Osp 2—C—C—Osp 3, is characterized by an O⋯O distance of 3.113 (2) Å and an O—C—C—O torsion angle of 97.8 (2)°. In the crystal structure, mol­ecules are linked by C—H⋯O contacts

2-(4-Chloro­phen­yl)-6-meth­oxy­chroman-4-one

In the title mol­ecule, C16H13Cl O3, the two aromatic rings form a dihedral angle of 65.3 (1)°. In the crystal structure, weak inter­molecular C—H⋯O hydrogen bonds link the mol­ecules into centrosymmetric dimers, which are further packed into columns propagating in [100] by weak C—H⋯π inter­actions