“I’ve Risen Up From the Ashes That I Created”: Record Clearance and Gendered Narratives of Self-Reinvention and Reintegration

Record clearance allows some individuals to redesignate or remove certain minor convictions from their criminal records. This interview-based study finds that both men and women seek opportunities for personal gain through record clearance, but women are more motivated by moral and religious influences and concern about reputation. Women are also more likely than men to acknowledge personal flaws, and to desire to replace criminal identities with law-abiding identities. As women redefine their identities, caregiving is especially important as a personal obligation and professional aspiration. Record clearance is particularly compatible with women’s motivations, willingness to change, and personal and professional goals

Beyond Recidivism: New Approaches to Research on Prisoner Reentry and Reintegration

Prison in the United States often has a revolving door, with droves of formerly incarcerated people ultimately finding themselves behind bars again. In Beyond Recidivism, Andrea Leverentz, Elsa Y. Chen, and Johnna Christian bring together a leading group of interdisciplinary scholars to examine this phenomenon using several approaches to research on recently released prisoners returning to their lives. They focus on the social context of reentry and look at the stories returning prisoners tell, including such key issues as when they choose to reveal (or not) their criminal histories. Drawing on contemporary studies, contributors examine the best ideas that have emerged over the last decade to understanding the challenges prisoners face upon reentering society. Together, they present a complete picture of prisoner reentry, including real-world recommendations for policies to ensure the well-being of returning prisoners, regardless of their past mistakes.https://scholarcommons.scu.edu/faculty_books/1494/thumbnail.jp

E-Payment Adoption in Saudi Arabia

Internet technology has influenced banking systems because of its capability to enhance the performance of financial operations. Several factors influence the adoption of new technology within the financial industry. Namely the customers’ perception of benefit, quality, Ease of Use, Security, Self-Efficacy, and Trust. However, various cultures and geopolitical issues influence technology adoption and are therefore worth further study. This paper focuses on the factors that influence the behaviors of Saudi Arabians and their adoption of e-payment systems. The paper shows the fundamental discoveries of an investigation examining the dispersion and the adoption of e-payment technology in Saudi Arabia. It reports new research that distinguishes and investigates the key issues that impact the population in Saudi Arabia regarding the use of electronic payment. Results show that employment status and self-efficacy are the variables that best explain the use of e-payment systems

TITLE Vinpocetine suppresses pathological vascular remodeling through inhibiting vascular smooth muscle cell proliferation and migration JPET #195446 2 RUNNING TITLE Vinpocetine inhibits pathological vascular remodeling

Abstract word number: 23

Structural Model Reveals Key Interactions in the Assembly of the Pregnane X Receptor/Corepressor Complex Running Title: Molecular Dynamics of PXR-SMRT Interactions

Abstract The human pregnane X receptor (PXR), also known as steroid and xenobiotic receptor (SXR), is a member of the orphan nuclear receptors and mediates the mammalian xenobiotic response with broad specificity and implications for drug clearance. The mouse pregnane X receptor is highly similar to the human ortholog in structure but with subtle species differentiation in the ligand binding domain (LBD). The C-terminal helix named α AF or AF-2 helix in other nuclear receptors is responsible for transcription activation by recruiting co-activators through conformational change. In the absence of ligands, PXR can also repress gene expression by interacting with transcriptional corepressors such as the silencing mediator for retinoid and thyroid hormone receptor (SMRT). We first constructed homology models of completed LBD with two SMRT nuclear receptor (NR)-interacting domains (ID1 and ID2) respectively. We then performed energy minimization and molecular dynamics simulations on these systems to study the specific interactions between the interacting domains and LBD. Further experimental results supported and validated the observed preference of SMRT toward ID2 over ID1. Our modeling results revealed the key interactions that account for the binding preference. Here, we propose structural models of the PXR-LBD/SMRT-ID1 and PXR-LBD/SMRT-ID2 complexes to understand their molecular interactions and potential inhibitory mechanism

Structural Model Reveals Key Interactions in the Assembly of the Pregnane X Receptor/Corepressor Complex Running Title: Molecular Dynamics of PXR-SMRT Interactions

Abstract The human pregnane X receptor (PXR), also known as steroid and xenobiotic receptor (SXR), is a member of the orphan nuclear receptors and mediates the mammalian xenobiotic response with broad specificity and implications for drug clearance. The mouse pregnane X receptor is highly similar to the human ortholog in structure but with subtle species differentiation in the ligand binding domain (LBD). The C-terminal helix named α AF or AF-2 helix in other nuclear receptors is responsible for transcription activation by recruiting co-activators through conformational change. In the absence of ligands, PXR can also repress gene expression by interacting with transcriptional corepressors such as the silencing mediator for retinoid and thyroid hormone receptor (SMRT). We first constructed homology models of completed LBD with two SMRT nuclear receptor (NR)-interacting domains (ID1 and ID2) respectively. We then performed energy minimization and molecular dynamics simulations on these systems to study the specific interactions between the interacting domains and LBD. Further experimental results supported and validated the observed preference of SMRT toward ID2 over ID1. Our modeling results revealed the key interactions that account for the binding preference. Here, we propose structural models of the PXR-LBD/SMRT-ID1 and PXR-LBD/SMRT-ID2 complexes to understand their molecular interactions and potential inhibitory mechanism