Additional file 1: of Footprints of domestication revealed by RAD-tag resequencing in loquat: SNP data reveals a non-significant domestication bottleneck and a single domestication event

Table S1. SNP dataset with less than 50% loss. Table S2. SNP dataset with no gap. (XLS 27844 kb

Elevated periostin in serum and peritoneal washing fluids as potential biomarkers for endometriosis

<p><i>Background</i>: To identify the level of periostin in serum and peritoneal washing fluids (PWF) from women with and without endometriosis, as well as to explore the potential of periostin as a biomarker of endometriosis.</p> <p><i>Methods</i>: Samples were obtained from 184 women with and without endometriosis. Concentrations of periostin in PWF and blood were measured by enzyme-linked immunosorbent assay.</p> <p><i>Results</i>: Levels of periostin both in serum and PWF were notably elevated in women with endometriosis in both the proliferative and secretory phase. Combined with dysmenorrhea and infertility, two potential covariates, the serum periostin had a sensitivity of 75.00%, specificity of 65.00%, and area under the curve (AUC) of 0.774, whereas the PWF periostin had a sensitivity of 94.23%, specificity of 90.00%, and AUC of 0.967 for the diagnosis of endometriosis.</p> <p><i>Conclusion</i>: Serum and PWF periostin concentrations may be new potential biomarkers for endometriosis, especially when combined with dysmenorrhea and infertility.</p

(Über-)Fachliche Unterstützung durch TREFFER

The Lewis acid-promoted phosphorylation of 2-indolylmethanols with diarylphosphine oxides is described. The regioselectivity of the reaction can be modulated by the choice of rare earth metal Lewis acid, offering a highly selective approach to structurally diverse indole derivatives in up to 97% yield for over 50 examples. This strategy features high selectivity, good functional group tolerance, and easy scalability. The utility of this method is further highlighted by facile modification of the products to access novel indole-based phosphine ligand

Lewis Acid-Controlled Regioselective Phosphorylation of 2‑Indolylmethanols with Diarylphosphine Oxides: Synthesis of Highly Substituted Indoles

The Lewis acid-promoted phosphorylation of 2-indolylmethanols with diarylphosphine oxides is described. The regioselectivity of the reaction can be modulated by the choice of rare earth metal Lewis acid, offering a highly selective approach to structurally diverse indole derivatives in up to 97% yield for over 50 examples. This strategy features high selectivity, good functional group tolerance, and easy scalability. The utility of this method is further highlighted by facile modification of the products to access novel indole-based phosphine ligand

Lewis Acid-Controlled Regioselective Phosphorylation of 2‑Indolylmethanols with Diarylphosphine Oxides: Synthesis of Highly Substituted Indoles

The Lewis acid-promoted phosphorylation of 2-indolylmethanols with diarylphosphine oxides is described. The regioselectivity of the reaction can be modulated by the choice of rare earth metal Lewis acid, offering a highly selective approach to structurally diverse indole derivatives in up to 97% yield for over 50 examples. This strategy features high selectivity, good functional group tolerance, and easy scalability. The utility of this method is further highlighted by facile modification of the products to access novel indole-based phosphine ligand

Rapid Self-Recoverable Hydrogels with High Toughness and Excellent Conductivity

Hydrogels as soft and wet materials have attracted much attention in sensing and flexible electronics. However, traditional hydrogels are fragile or have unsatisfactory recovery capability, which largely limit their applications. Here, a novel hydrogen bond based sulfuric acid–poly­(acrylic acid) (PAA)/poly­(vinyl alcohol) physical hydrogel is developed for addressing the above drawbacks. Sulfuric acid serves two functions: one is to inhibit the ionization of carboxyl groups from PAA chains to form more hydrogen bonds and the other is to provide conductive ions to promote conductivity of hydrogel. Consequently, the hydrogel obtains comprehensive mechanical properties, including extremely rapid self-recovery (strain = 1, instantly self-recover; strain = 20, self-recover within 10 min), high fracture strength (3.1 MPa), and high toughness (18.7 MJ m^–3). In addition, we demonstrate this hydrogel as a stretchable ionic cable and pressure sensor to exhibit stable operation after repeated loadings. This work provides a new concept to synthesize physical hydrogels, which will hopefully expand applications of hydrogel in stretchable electronics

Rapid Self-Recoverable Hydrogels with High Toughness and Excellent Conductivity

Hydrogels as soft and wet materials have attracted much attention in sensing and flexible electronics. However, traditional hydrogels are fragile or have unsatisfactory recovery capability, which largely limit their applications. Here, a novel hydrogen bond based sulfuric acid–poly­(acrylic acid) (PAA)/poly­(vinyl alcohol) physical hydrogel is developed for addressing the above drawbacks. Sulfuric acid serves two functions: one is to inhibit the ionization of carboxyl groups from PAA chains to form more hydrogen bonds and the other is to provide conductive ions to promote conductivity of hydrogel. Consequently, the hydrogel obtains comprehensive mechanical properties, including extremely rapid self-recovery (strain = 1, instantly self-recover; strain = 20, self-recover within 10 min), high fracture strength (3.1 MPa), and high toughness (18.7 MJ m^–3). In addition, we demonstrate this hydrogel as a stretchable ionic cable and pressure sensor to exhibit stable operation after repeated loadings. This work provides a new concept to synthesize physical hydrogels, which will hopefully expand applications of hydrogel in stretchable electronics

<i>P</i>-values of a two-way ANOVA for the effects of <i>Lactobacillus acidophilus</i>, time, and their interactions on the ten variables (N = 90).

<p>Note: MLCK: myosin light chain kinase; MLCP: myosin light chain phosphatase; PKC: protein kinase C; ICC numbers: the numbers of interstitial cells of Cajal.</p><p>*indicates a significant difference (<i>P</i> < 0.05)</p><p>**indicates a highly significant difference (<i>P</i> < 0.01).</p><p><i>P</i>-values of a two-way ANOVA for the effects of <i>Lactobacillus acidophilus</i>, time, and their interactions on the ten variables (N = 90).</p

<i>Lactobacillus acidophilus</i> could increase the MLC₂₀ phosphorylation.

<p>The interaction of <i>Lactobacillus acidophilus</i> and time on MLC₂₀ phosphorylation was not significant. (A and B) The levels of phospho-MLC₂₀ in intestinal smooth muscle were significantly decreased after TBI, *<i>P</i> < 0.05 compared with control. Treating with <i>Lactobacillus acidophilus</i> attenuated TBI-mediated inhibition of MLC₂₀ phosphorylation, #<i>P</i> < 0.05 compared with TBI. (C) The marked decreases in immunoreactivity for phospho-MLC₂₀ were observed in intestinal smooth muscle after TBI, and treatment with <i>Lactobacillus acidophilus</i> significantly attenuated TBI-mediated inhibition of MLC₂₀ phosphorylation.</p

<i>Lactobacillus acidophilus</i> improved the contractile activity of intestinal smooth muscle impaired by TBI.

<p>Ninety C57BL/6 mice were randomly divided into three groups including control, TBI and TBI + <i>Lactobacillus acidophilus</i> groups. The interaction of <i>Lactobacillus acidophilus</i> and time on intestinal contractile activity was not significant. (A) The contractile activity was determined by histologic and physiologic analyses. (B) The average contractile amplitude was decreased after TBI, **<i>P</i> < 0.01 compared with control. <i>Lactobacillus acidophilus</i> could increase in contractile amplitude, #<i>P</i> < 0.05 compared with TBI. (C and D) The contractile frequency and tension were also decreased after TBI, **<i>P</i> < 0.01 compared with control. <i>Lactobacillus acidophilus</i> significantly attenuated TBI-mediated decreases of contractile frequency and tension, #<i>P</i> < 0.05 compared with TBI. (E) The intestinal transit rate was decreased after TBI, **<i>P</i> < 0.01 compared with control. <i>Lactobacillus acidophilus</i> significantly attenuated TBI-mediated decrease of intestinal transit rate, ##<i>P</i> < 0.01 compared with TBI.</p