The View of Women in Buddhism - From the Comparison between the Bhikkhu and Bhikkhuni Precepts

In Buddhism, monks and nuns or bhikkhu and bhikkhuni in Pali refer to those who leave their homes to practices Buddhism and live ascetic lives with other monks or nuns. Monks and nuns play important roles in Buddhism, because they are considered to be the successors of the Buddha dharma after the death of the Sakyamuni Buddha and therefore are responsible for teaching and passing on the Buddha dharma. Precepts are the rules that the Buddha made to prohibit the behavior that may obstruct the experiencing of enlightenment. By upholding the precepts strictly, people can experience nirvana. In order to help monks and nuns, who devote their whole lives to practice Buddhism, to experience nirvana sooner, the Buddha made stricter precepts for them than for lay people who practice Buddhism at home while doing secular business. The precepts for monks and the precepts for nuns are called the Bhikkhu Patimokkha and the Bhikkhuni Patimokkha, which were made based on the misbehavior of monks and nuns. However, there are many differences between the Bhikkhu Patimokkha and the Bhikkhuni Patimokkha, showing the differences between women and men, such as physical differences, different habits and psychologies, and different social roles, and the view of the Buddha that a greater percentage of women has deeper vasanas (subconscious bad habits from previous lives) than men have. For this reason, some people charge Buddhism because they think the Buddha discriminated against women. Nonetheless, the Buddha’s view towards women is based on the facts rather than the stereotype of women, which can be seen in the analysis in the following chapters. Moreover, in Buddhism, it is thought that this situation of women is not caused by women’s bodily characteristics but by their psychologies and certain social customs. In other words, these bad habits are not inherent and unchangeable, and can be changed with the change of the time and the social context. Furthermore, the degree of having bad habits does not influence the fact that every sentient being is able to experience enlightenment, so women indeed have the same possibility of experiencing nirvana as men have by practicing Buddhism to surpass themselves, which can be found throughout many Buddhist sutras

Effects of Palatable Food Versus Thin Figure Conflicts on Responses of Young Dieting Women

Many young women use dieting to achieve a thinner figure yet most tend to fail as a result of heightened responsiveness to palatable food environments and increases in hedonic cravings. In this preliminary study, we developed a novel palatable food vs. thin figure conflict task to assess conflicting motives associated with eating among young women. Forty young dieting women [mean body mass index (BMI) = 22.98 kg/m2, SD = 3.81] completed a food vs. figure conflict task within a 2 (distractor image: food vs. figure) × 2 (word-image congruence: congruent vs. incongruent) within-subjects design. Results supported the view that this new task could effectively capture conflict costs. Dieting young women displayed stronger food conflicts than figure conflicts based on having longer response delays and higher error rates in the food conflict condition than the figure conflict condition. Although young women often proclaimed “dieting” to achieve or maintain a good figure, dieters appeared to exhibit stronger preferences for palatable food cues relative to thin figure cues. These results provide important information for understanding automatic processing biases toward palatable foods and underscore the need for research extensions in other cultural contexts to determine whether such biases are universal in nature

Sex differences in neural substrates of risk taking: Implications for sex-specific vulnerabilities to internet gaming disorder

Background and aims: Sex differences in internet gaming disorder (IGD) remain unknown. Investigating sex-specific neural features that underlie the core risk factor (i.e., risk-taking) of IGD would help in understanding sex-specific vulnerabilities to IGD and advance sex-specific treatments and prevention for IGD. Methods: 111 participants (28 IGD males, 27 IGD females, 26 recreational game user (RGU) males, 30 RGU females) completed a probability discounting task during fMRI scanning. Results: First, among RGUs, males showed a higher risk-taking tendency and greater neural activation associated with risk/ value evaluation for reward (the ventromedial prefrontal cortex (vmPFC), anterior cingulate cortex (ACC), left putamen) and smaller activation associated with cognitive control (the inferior frontal gyrus) than females during the contrast of risky-safe choices. Moreover, males showed a greater modulatory effect of risky choices on the connection from the vmPFC/ACC to the left putamen than females. Second, IGD males showed decreased activation in the vmPFC/ACC and left putamen compared to RGU males, whereas this decrease did not exist in IGD females. Discussion: Males show a higher risktaking tendency than females. Altered neural substrates associated with risky decision-making exist in IGD males but not in IGD females. Conclusions: The present findings fill the gap in information on the behavioral and neural substrates underlying IGD among females and demonstrate that a high risk-taking tendency is a risk factor and core symptom only in IGD males but not in IGD females. It is necessary to design and adopt distinct treatments and prevention strategies for IGD in males and females

Deep muscularis propria tumor invasion without lymph node metastasis as a unique subclassification of stage IB gastric cancer: a retrospective study

BACKGROUND: The prognosis difference based on the depth of tumor muscularis propria invasion in gastric cancer (GC) was still debated, and therapy strategy for stage IB GC patient required further investigation. METHODS: A total of 380 patients with pT2 GC after radical surgery were retrospectively analyzed, including 185 in superficial muscularis propria (sMP) group and 195 in deep muscularis propria (dMP) group. RESULTS: The overall survival (OS) was significantly better for patients in sMP group than for patients in dMP group (P = 0.007). In multivariate analysis, depth of tumor invasion, pN stage, age, primary location, positive expression of p53, elevated maximal LDH, elevated initial CA19-9 and AFP level were independent prognostic factors for OS. The sMP group had a significantly better OS than dMP group (P = 0.014) in pN0 stage. After further stratification, the survival outcomes were not significantly different between deep muscularis propria tumor invasion without lymph node metastasis (dMPN0) group (stage IB) and superficial muscularis propria tumor invasion with stage 1-2 lymph node metastasis (sMPN1-2) group (stage II) (P = 0.100). Patients with adjuvant chemotherapy had a statistically better survival than those without in dMPN0 group (P = 0.045) and dMPN0 patients with adjuvant chemotherapy had better OS than sMPN1-2 patients (P = 0.015). In addition, greater postoperative survival could be observed in sMPN0 patients than dMPN0 patients in p53-positive group (P = 0.002), and similar OS could be seen between dMPN0 patients with p53-positive and T2N1-2 patients (P = 0.872). CONCLUSION: As a unique subclassification of stage IB GC, appropriate adjuvant chemotherapy should be considered for patients with dMPN0 stage. In addition, positive expression of p53, elevated LDH could be potential factors in identifying the different prognoses for stage IB GC patients

A cohort study of the efficacy and safety of immune checkpoint inhibitors plus anlotinib versus immune checkpoint inhibitors alone as the treatment of advanced non-small cell lung cancer in the real world

BACKGROUND: Anlotinib is a new multi-target tyrosine kinase inhibitor (TKI) and has been shown to have antitumor effects and synergistic antitumor effects with immunotherapy only in animal studies and in the 2nd-line treatment in small clinical trials. A real-world study with large sample to compare the efficacy and safety of anlotinib plus immune checkpoint inhibitors (ICIs) with ICIs alone in the multiline treatment of advanced non-small cell lung cancer (NSCLC) was urgently needed. METHODS: The data of 535 advanced NSCLC patients were collected from January 1, 2018, to December 31, 2021. The patients were divided into 2 groups: (I) ICI monotherapy (230 patients); (II) ICI + anlotinib (305 patients). After propensity-score matching (PSM) to reduce the effects of biases and confounding variables, the progression-free survival time (PFS), occurrence of adverse events, disease control rate (DCR), and objective response rate (ORR) of the 2 groups were compared. The effects of clinical factors, including age, gender, gene mutations, tumor proportion score, metastases, and combined radiotherapy, were also analyzed. RESULTS: After PSM, the baseline clinical characteristics were well balanced and the 2 group had a good comparability. Patients in the ICI + anlotinib group had significantly longer median PFS in both the 2nd-line treatment (7.73 vs. 4.70 months; P=0.003) and 3rd-line treatment (5.90 vs. 3.37 months; P=0.020), but the difference lacked statistical significance in the 1st-line treatment (8.40 vs. 5.20 months; P=0.229). The overall median PFS of patients in the ICI + anlotinib group was also much longer than that of patients in the ICI monotherapy group (6.37 vs. 3.90 months; P<0.001). The ICI + anlotinib group also tended to have a higher DCR, a higher ORR, and a higher probability of severe adverse drug reactions during the treatment than the ICI monotherapy group, but the differences were not statistically significant. Combining ICI + anlotinib could improve the outcomes of patients with bone metastasis. CONCLUSIONS: Anlotinib + ICI therapy could have greater efficacy in the treatment of advanced NSCLC patients than ICI monotherapy. The probability of adverse events might increase in the combined treatment, but could be controlled

General and Food-Specific Inhibitory Control As Moderators of the Effects of the Impulsive Systems on Food Choices

The present study aimed to extend the application of the reflective-impulsive model to restrained eating and explore the effect of automatic attention (impulsive system) on food choices. Furthermore, we examined the moderating effects of general inhibitory control (G-IC) and food-specific inhibitory control (F-IC) on successful and unsuccessful restrained eaters (US-REs). Automatic attention was measured using “the EyeLink 1000,” which tracked eye movements during the process of making food choices, and G-IC and F-IC were measured using the Stop-Signal Task. The results showed that food choices were related to automatic attention and that G-IC and F-IC moderated the predictive relationship between automatic attention and food choices. Furthermore, among successful restrained eaters (S-REs), automatic attention to high caloric foods did not predict food choices, regardless of whether G-IC or F-IC was high or low. Whereas food choice was positively correlated with automatic attention among US-REs with poor F-IC, this pattern was not observed in those with poor G-IC. In conclusion, the S-REs had more effective self-management skills and their food choices were affected less by automatic attention and inhibitory control. Unsuccessful restrained eating was associated with poor F-IC (not G-IC) and greater automatic attention to high caloric foods. Thus, clinical interventions should focus on enhancing F-IC, not G-IC, and on reducing automatic attention to high caloric foods

Genetic architecture of microhabitat adaptation traits in a pair of sympatric Primulina species

AbstractExploring the genetic basis of adaptive divergence at fine spatial scales can broaden our basic understanding of evolution and how organisms may adapt to changing environments in the future. Cave-associated microhabitats provide a unique opportunity to gain insight into microgeographic adaptation. We studied the genetic architecture of microhabitat-related divergence in flower phenology and leaf traits between two sister species of Primulina, P. depressa and P. danxiaensis, which live in sympatry but occupy contrasting microhabitats. We identified 40 significant quantitative trait loci (QTLs) associated with the interspecific differences in these microhabitat adaptation traits. Flowering time was controlled by one major-effect and six minor-effect QTLs, while leaf traits were influenced by 9–12 QTLs of small to moderate effect. The genetic architecture of the flowering time and the specific leaf area was genetically independent of other traits. Our results suggest that microhabitat adaptation in sympatric populations of Primulina differs according to different traits, with leaf traits diverging with the accumulation of many small changes and flowering phenology being driven by major effect variance

Supplementary Figures for "Genetic architecture of microhabitat adaptation traits"

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