453 research outputs found
Towards Accurate One-Stage Object Detection with AP-Loss
One-stage object detectors are trained by optimizing classification-loss and
localization-loss simultaneously, with the former suffering much from extreme
foreground-background class imbalance issue due to the large number of anchors.
This paper alleviates this issue by proposing a novel framework to replace the
classification task in one-stage detectors with a ranking task, and adopting
the Average-Precision loss (AP-loss) for the ranking problem. Due to its
non-differentiability and non-convexity, the AP-loss cannot be optimized
directly. For this purpose, we develop a novel optimization algorithm, which
seamlessly combines the error-driven update scheme in perceptron learning and
backpropagation algorithm in deep networks. We verify good convergence property
of the proposed algorithm theoretically and empirically. Experimental results
demonstrate notable performance improvement in state-of-the-art one-stage
detectors based on AP-loss over different kinds of classification-losses on
various benchmarks, without changing the network architectures. Code is
available at https://github.com/cccorn/AP-loss.Comment: 13 pages, 7 figures, 4 tables, main paper + supplementary material,
accepted to CVPR 201
Dynamics of a stochastic fractional nonlocal reaction-diffusion model driven by additive noise
In this paper, we are concerned with the long-time behavior of stochastic fractional nonlocal reaction-diffusion equations driven by additive noise. We use the techniques of random dynamical
systems to transform the stochastic model into a random one. To deal with the new nonlocal term
appeared in the transformed equation, we first use a generalization of Peano’s theorem to prove the
existence of local solutions, and then adopt the Galerkin method to prove existence and uniqueness of weak solutions. Next, the existence of pullback attractors for the equation and its associated
Wong-Zakai approximation equation driven by colored noise are shown, respectively. Furthermore, we
establish the upper semi-continuity of random attractors of the Wong-Zakai approximation equation
as δ → 0 +
Parameter Estimation of Induction Machine at Standstill Using Two-Stage Recursive Least Squares Method
This paper presents a two-stage recursive least squares (TSRLS) algorithm for the electric parameter estimation of the induction machine (IM) at standstill. The basic idea of this novel algorithm is to decouple an identifying system into two subsystems by using decomposition technique and identify the parameters of each subsystem, respectively. The TSRLS is an effective implementation of the recursive least squares (RLS). Compared with the conventional (RLS) algorithm, the TSRLS reduces the number of arithmetic operations. Experimental results verify the effectiveness of the proposed TSRLS algorithm for parameter estimation of IMs
mGluR5 regulated proliferation of neural stem cells after hypoxia with activation of MAPK signaling pathway
Self-renewal potential of NPCs decreased in vitro during human embryonic brain development with reduced activation of mitogen-activated protein kinases signaling
Small RNA zippers lock miRNA molecules and block miRNA function in mammalian cells.
MicroRNAs (miRNAs) loss-of-function phenotypes are mainly induced by chemically modified antisense oligonucleotides. Here we develop an alternative inhibitor for miRNAs, termed \u27small RNA zipper\u27. It is designed to connect miRNA molecules end to end, forming a DNA-RNA duplex through a complementary interaction with high affinity, high specificity and high stability. Two miRNAs, miR-221 and miR-17, are tested in human breast cancer cell lines, demonstrating the 70∼90% knockdown of miRNA levels by 30-50 nM small RNA zippers. The miR-221 zipper shows capability in rescuing the expression of target genes of miR-221 and reversing the oncogenic function of miR-221 in breast cancer cells. In addition, we demonstrate that the miR-221 zipper attenuates doxorubicin resistance with higher efficiency than anti-miR-221 in human breast cancer cells. Taken together, small RNA zippers are a miRNA inhibitor, which can be used to induce miRNA loss-of-function phenotypes and validate miRNA target genes
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