Determining Epipole Location Integrity by Multimodal Sampling

International audienceIn urban cluttered scenes, a photo provided by a wear-able camera may be used by a walking law-enforcement agent as an additional source of information for localizing themselves, or elements of interest related to public safety and security. In this work, we study the problem of locating the epipole, corresponding to the position of the moving camera, in the field of view of a reference camera. We show that the presence of outliers in the standard pipeline for camera relative pose estimation not only prevents the correct estimation of the epipole localization but also degrades the standard uncertainty propagation for the epipole position. We propose a robust method for constructing an epipole location map, and we evaluate its accuracy as well as its level of integrity with respect to standard approaches

Neurotrophic basis to the pathogenesis of depression and phytotherapy

Depression is a major neuropsychiatric disease that considerably impacts individuals’ psychosocial function and life quality. Neurotrophic factors are now connected to the pathogenesis of depression, while the definitive neurotrophic basis remains elusive. Besides, phytotherapy is alternative to conventional antidepressants that may minimize undesirable adverse reactions. Thus, further research into the interaction between neurotrophic factors and depression and phytochemicals that repair neurotrophic factors deficit is highly required. This review highlighted the implication of neurotrophic factors in depression, with a focus on the brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), vascular endothelial growth factor (VEGF), and nerve growth factor (NGF), and detailed the antidepressant activities of various phytochemicals targeting neurotrophic factors. Additionally, we presented future opportunities for novel diagnostic and therapeutic strategies for depression and provided solutions to challenges in this area to accelerate the clinical translation of neurotrophic factors for the treatment of depression

Multiple Solutions to Fractional Difference Boundary Value Problems

The following fractional difference boundary value problems ▵νyt=-ft+ν-1,yt+ν-1, y(ν-2)=y(ν+b+1)=0 are considered, where 1<ν≤2 is a real number and ▵νy(t) is the standard Riemann-Liouville fractional difference. Based on the Krasnosel’skiǐ theorem and the Schauder fixed point theorem, we establish some conditions on f which are able to guarantee that this FBVP has at least two positive solutions and one solution, respectively. Our results significantly improve and generalize those in the literature. A number of examples are given to illustrate our main results

Multiobjective Location Routing Problem considering Uncertain Data after Disasters

The relief distributions after large disasters play an important role for rescue works. After disasters there is a high degree of uncertainty, such as the demands of disaster points and the damage of paths. The demands of affected points and the velocities between two points on the paths are uncertain in this article, and the robust optimization method is applied to deal with the uncertain parameters. This paper proposes a nonlinear location routing problem with half-time windows and with three objectives. The affected points can be visited more than one time. The goals are the total costs of the transportation, the satisfaction rates of disaster nodes, and the path transport capacities which are denoted by vehicle velocities. Finally, the genetic algorithm is applied to solve a number of numerical examples, and the results show that the genetic algorithm is very stable and effective for this problem

Ginsenoside Rg1 Ameliorates Neuroinflammation via Suppression of Connexin43 Ubiquitination to Attenuate Depression

Depression is an inflammation-associated disease that results in major depression as inflammation increases and progresses. Ginsenoside Rg1 (Rg1), the major bioactive ingredient derived from ginseng, possesses remarkable anti-depressant and anti-inflammatory effects. Our previous studies showed that the pathogenesis of depression was concomitant with the acceleration of connexin43 (Cx43) ubiquitin degradation, while Rg1 could upregulate Cx43 expression to attenuate depression. However, whether the ubiquitination of Cx43 is the specific correlation between depression and inflammation, and how Rg1 ameliorates neuroinflammation to attenuate depression, are still under investigation. In in vivo experiments, Rg1 treatment significantly ameliorated depression-like behaviors in rats subjected to chronic unpredictable stress (CUS). Moreover, these CUS rats treated with Rg1 exhibited attenuated neuroinflammation, together with the suppression of Cx43 ubiquitination. In in vitro experiments, Rg1 reduced the secretion of inflammatory cytokines and the ubiquitination of Cx43 in lipopolysaccharide-induced glial cells. Furthermore, treatment with ubiquitin-proteasome inhibitor MG132 suppressing the ubiquitination of Cx43 ameliorated lipopolysaccharide-induced neuroinflammation. The results suggest that Rg1 attenuates depression-like behavioral performances in CUS-exposed rats; and the main mechanism of the antidepressant-like effects of Rg1 appears to involve protection against neuroinflammation via suppression of Cx43 ubiquitination. In conclusion, Rg1 could ameliorate neuroinflammation via suppression of Cx43 ubiquitination to attenuate depression, which represents the perspective of an innovative therapy of Rg1 in the treatment of inflammation-associated depression

Transmembrane routes of cationic liposome-mediated gene delivery using human throat epidermis cancer cells

For studying the mechanism of cationic liposome-mediated transmembrane routes for gene delivery, various inhibitors of endocytosis were used to treat human throat epidermis cancer cells, Hep-2, before transfection with Lipofectamine 2000/pGFP-N2 or Lipofectamine 2000/pGL3. To eliminate the effect of inhibitor toxicity on transfection, the RLU/survival rate was used to represent the transfection efficiency. Chlorpromazine and wortmannin, clathrin inhibitors, decreased transfection efficiency by 44 % (100 μM) and 31 % (100 nM), respectively. At the same time, genistein, a caveolin inhibitor, decreased it by 30 % (200 μM). Thus combined transmembrane routes through the clathrin and caveolae-mediated pathways were major mechanisms of cell uptake for the cationic liposome-mediated gene delivery. After entering the cells, microtubules played an important role on gene delivery as vinblastine, a microtubulin inhibitor, could reduce transfection efficiency by 41 % (200 nM)