The spatial competition between containerised rail and sea transport in Eurasia

The competition in space between rail and sea transport is of great significance to the integration of Eurasia. This paper proposes a land and sea transport spatial balance model for container transport, which can extract a partition line on which transport costs by rail and sea are equal given a destination. Four scenarios are discussed to analyse the effects of different factors on the model. Then the model is empirically tested on current rail and sea transport networks to identify the transport competition pattern in Eurasia. The location of destinations, the freight costs, and time costs are the three main factors affecting the model. Among them, time costs are determined by the value of a container and its contents, the interest rate, and by time differences between land and sea transport. The case study shows that Eurasia forms a transport competition pattern with a land area to sea area ratio of about 1:2; this ratio, however, changes to 1:1 when time costs are considered. Further, the land and sea transport balance lines are consistent with the theories of geopolitics, which indicate that the same processes may exist in the spatial pattern of geo-economics and geopolitics in Eurasia. According to the balance lines, we get a spatial partition, dividing Eurasia into the land transport preferred area, the land–sea transport indifference area, and the sea transport preferred area. The paper brings a new perspective to the exploration of geopolitical economic spatial patterns of Eurasia and provides a practical geographic theory as an analytic basis for the implementation of the Belt and Road Initiative

Open String Creation by S-Branes

An sp-brane can be viewed as the creation and decay of an unstable D(p+1)-brane. It is argued that the decaying half of an sp-brane can be described by a variant of boundary Liouville theory. The pair creation of open strings by a decaying s-brane is studied in the minisuperspace approximation to the Liouville theory. In this approximation a Hagedorn-like divergence is found in the pair creation rate, suggesting the s-brane energy is rapidly transferred into closed string radiation.Comment: Talk presented at the Hangzhou String 2002 Conference, August 12-1

Modeling the functional genomics of autism using human neurons.

Human neural progenitors from a variety of sources present new opportunities to model aspects of human neuropsychiatric disease in vitro. Such in vitro models provide the advantages of a human genetic background combined with rapid and easy manipulation, making them highly useful adjuncts to animal models. Here, we examined whether a human neuronal culture system could be utilized to assess the transcriptional program involved in human neural differentiation and to model some of the molecular features of a neurodevelopmental disorder, such as autism. Primary normal human neuronal progenitors (NHNPs) were differentiated into a post-mitotic neuronal state through addition of specific growth factors and whole-genome gene expression was examined throughout a time course of neuronal differentiation. After 4 weeks of differentiation, a significant number of genes associated with autism spectrum disorders (ASDs) are either induced or repressed. This includes the ASD susceptibility gene neurexin 1, which showed a distinct pattern from neurexin 3 in vitro, and which we validated in vivo in fetal human brain. Using weighted gene co-expression network analysis, we visualized the network structure of transcriptional regulation, demonstrating via this unbiased analysis that a significant number of ASD candidate genes are coordinately regulated during the differentiation process. As NHNPs are genetically tractable and manipulable, they can be used to study both the effects of mutations in multiple ASD candidate genes on neuronal differentiation and gene expression in combination with the effects of potential therapeutic molecules. These data also provide a step towards better understanding of the signaling pathways disrupted in ASD

86 PFLOPS Deep Potential Molecular Dynamics simulation of 100 million atoms with ab initio accuracy

We present the GPU version of DeePMD-kit, which, upon training a deep neural network model using ab initio data, can drive extremely large-scale molecular dynamics (MD) simulation with ab initio accuracy. Our tests show that the GPU version is 7 times faster than the CPU version with the same power consumption. The code can scale up to the entire Summit supercomputer. For a copper system of 113, 246, 208 atoms, the code can perform one nanosecond MD simulation per day, reaching a peak performance of 86 PFLOPS (43% of the peak). Such unprecedented ability to perform MD simulation with ab initio accuracy opens up the possibility of studying many important issues in materials and molecules, such as heterogeneous catalysis, electrochemical cells, irradiation damage, crack propagation, and biochemical reactions.Comment: 29 pages, 11 figure

High photo-excited carrier multiplication by charged InAs dots in AlAs/GaAs/AlAs resonant tunneling diode

We present an approach for the highly sensitive photon detection based on the quantum dots (QDs) operating at temperature of 77K. The detection structure is based on an AlAs/GaAs/AlAs double barrier resonant tunneling diode combined with a layer of self-assembled InAs QDs (QD-RTD). A photon rate of 115 photons per second had induced 10nA photocurrent in this structure, corresponding to the photo-excited carrier multiplication factor of 10^7. This high multiplication factor is achieved by the quantum dot induced memory effect and the resonant tunneling tuning effect of QD-RTD structure.Comment: 10 pages,5 figures. Submitted to Applied Physics Letter

Effect of sequence and metal ions on UVB-induced anti cyclobutane pyrimidine dimer formation in human telomeric DNA sequence

Irradiation of G-quadruplex forming human telomeric DNA with ultraviolet B (UVB) light results in the formation of anti cyclobutane pyrimidine dimers (CPDs) between loop 1 and loop 3 in the presence of potassium ions but not sodium ions. This was unexpected because the sequences involved favor the nonphotoreactive hybrid conformations in K+ solution, whereas a potentially photoreactive basket conformation is favored in Na+ solution. To account for these contradictory results, it was proposed that the loops are too far apart in the basket conformation in Na+ solution but close enough in a two G-tetrad basket-like form 3 conformation that can form in K+ solution. In the current study, Na+ was still found to inhibit anti CPD formation in sequences designed to stabilize the form 3 conformation. Furthermore, anti CPD formation in K+ solution was slower for the sequence previously shown to exist primarily in the proposed photoreactive form 3 conformation than the sequence shown to exist primarily in a nonphotoreactive hybrid conformation. These results suggest that the form 3 conformation is not the principal photoreactive conformation, and that G-quadruplexes in K+ solution are dynamic and able to access photoreactive conformations more easily than in Na+ solution

The contribution of ultracompact dark matter minihalos to the isotropic radio background

The ultracompact minihalos could be formed during the earlier epoch of the universe. The dark matter annihilation within them is very strong due to the steep density profile, $\rho \sim r^{-2.25}$. The high energy electrons and positrons from the dark matter annihilation can inverse Compton scatter (ICS) with the background photons, such as CMB photons, to acquire higher energy. On the other hand, the synchrotron radiation can also be produced when they meet the magnetic field. In this paper, we study the signals from the UCMHs due to the dark matter annihilation for the radio, X-ray and $\gamma$-ray band. We found that for the radio emission the UCMHs can provide one kind of source for the radio excess observed by ARCADE 2. But the X-ray signals due to the ICS effect or the $\gamma$-ray signals mainly due to the prompt emission from dark matter would exceed the present observations, such as Fermi, COMPTEL and CHANDRA. We found that the strongest limits on the fraction of UCMHs come from the X-ray observations and the constraints from the radio data are the weakest.Comment: 6 pages, 8 figures, Comments Welcome! Some Refs. are added, some presentation have been corrected. The conclusions remain unchanged. One important reference has been corrected. Some presentations are changed and added according to the referee's comments. Accepted for publication in PR