Sleep‐disordered breathing in major depressive disorder

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/99077/1/jsr12029.pd

CO-OPETITION STRATEGY FROM THE PATENT ANALYSIS PERSPECTIVE: THE CASE OF THE STENT MARKET

Information about technological innovation and its evolutionary path can be explored by patent analysis. Therefore, for those firms which are dependant on large investments and a high business performance, such as stent manufacturers, integrating patent information with business strategy is the critical issue. The competition between stent manufactures is intensifying because of increasing global volume demand and improving technological performance. From a resource-based view, adopting a co-opetition strategy is essential for firms to keep sustainable competitive advantage. Over the last decade, patent rights have become a major tool of the co-opetition strategy. This study analyzes patent data from the USPTO during 1984 to 2005 and constructs patent information indicators to verify the process of technology evolution. On these grounds, we can understand the relative technological position and technological strength of the major manufacturers in this industry and also inspect their changes of position and business scope to examine the relationship between each firm's technology strategy and business strategy.patent strategy, co-opetition strategy, stent

Deciphering Early-Stage Molecular Mechanisms of Negative Pressure Wound Therapy in a Murine Model

Negative Pressure Wound Therapy (NPWT) is a commonly employed clinical strategy for wound healing, yet its early-stage mechanisms remain poorly understood. To address this knowledge gap and overcome the limitations of human trials, we establish an NPWT C57BL/6JNarl mouse model to investigate the molecular mechanisms involved in NPWT. In this study, we investigate the intricate molecular mechanisms through which NPWT expedites wound healing. Our focus is on NPWT’s modulation of inflammatory immune responses and the concurrent orchestration of multiple signal transduction pathways, resulting in shortened coagulation time and reduced inflammation. Notably, we observe a significant rise in dickkopf-related protein 1 (DKK-1) concentration during NPWT, promoting the differentiation of Hair Follicle Stem Cells (HFSCs) into epidermal cells, expediting wound closure. Under negative pressure, macrophages express and release DKK-1 cytokines, crucial for stimulating HFSC differentiation, as validated in animal experiments and in vitro studies. Our findings illuminate the inflammatory dynamics under NPWT, revealing potential signal transduction pathways. The proposed framework, involving early hemostasis, balanced inflammation, and macrophage-mediated DKK-1 induction, provides a novel perspective on enhancing wound healing during NPWT. Furthermore, these insights lay the groundwork for future pharmacological advancements in managing extensive wounds, opening avenues for targeted therapeutic interventions in wound care