38 research outputs found
Local atomic and magnetic structure of dilute magnetic semiconductor (Ba,K)(Zn,Mn)As
We have studied the atomic and magnetic structure of the dilute ferromagnetic
semiconductor system (Ba,K)(Zn,Mn)As through atomic and magnetic pair
distribution function analysis of temperature-dependent x-ray and neutron total
scattering data. We detected a change in curvature of the temperature-dependent
unit cell volume of the average tetragonal crystallographic structure at a
temperature coinciding with the onset of ferromagnetic order. We also observed
the existence of a well-defined local orthorhombic structure on a short length
scale of \AA, resulting in a rather asymmetrical local environment
of the Mn and As ions. Finally, the magnetic PDF revealed ferromagnetic
alignment of Mn spins along the crystallographic -axis, with robust
nearest-neighbor ferromagnetic correlations that exist even above the
ferromagnetic ordering temperature. We discuss these results in the context of
other experiments and theoretical studies on this system
Prognostic value of MRI-derived masticator space involvement in IMRT-treated nasopharyngeal carcinoma patients
New insights into the impact of polystyrene micro/nanoplastics on the nutritional quality of marine jacopever (Sebastes schlegelii)
Microplastics (MPs) and nanoplastics (NPs) are ubiquitous in the marine environments due to the wide use and mismanagement of plastics. However, the effect of MPs/NPs on the nutrition quality of economic species is poorly understood, and their underlying mechanisms remained unclear. We therefore investigated the impacts of polystyrene MPs/NPs on the nutrition composition of marine jacopever Sebastes schlegelii from the perspective of assimilation and metabolism. Results showed that NPs reduced more nutrition quality than MPs. Despite no notable impact on intestinal microbiota function, MPs/NPs influenced the assimilation of fish through intestinal damage. Furthermore, NPs induced greater damage to hepatocyte metabolism than MPs, caused by hepatocyte uptake through membrane protein pumps/channels and clathrin/caveolin-mediated endocytosis for NPs, while through phagocytosis/pinocytosis for MPs. NPs triggered more cell apoptosis signals in Ferroptosis and FoxO signaling pathways than MPs, destroying mitochondria structure. Compared with MP treatments, a significant upregulation of genes (PRODH and SLC25A25A) associated with the electron transfer chain of mitochondria was detected in the NP treatments, influencing the tricarboxylic acid cycle and interfering with liver metabolism of proteins, fatty acid, glycerol phospholipids, and carbohydrates. This work provides new insights into the potential impacts of MPs/NPs on the quality and safety of seafood.publishedVersio
Prolonged mixed phase induced by high pressure in MnRuP
Hexagonally structured MnRuP was studied under high pressure up to 35 GPa
from 5 to 300 K using synchrotron X-ray diffraction. We observed that a partial
phase transition from hexagonal to orthorhombic symmetry started at 11 GPa. The
new and denser orthorhombic phase coexisted with its parent phase for an
unusually long pressure range, {\Delta}P ~ 50 GPa. We attribute this structural
transformation to a magnetic origin, where a decisive criterion for the
boundary of the mixed phase lays in the different distances between the Mn-Mn
atoms. In addition, our theoretical study shows that the orthorhombic phase of
MnRuP remains steady even at very high pressures up to ~ 250 GPa, when it
should transform to a new tetragonal phase.Comment: 15 pages, 5 figures, supplementary materia
The application value of LAVA-flex sequences in enhanced MRI scans of nasopharyngeal carcinoma: comparison with T1WI-IDEAL
IntroductionMagnetic resonance imaging (MRI) staging scans are critical for the diagnosis and treatment of patients with nasopharyngeal cancer (NPC). We aimed to evaluate the application value of LAVA-Flex and T1WI-IDEAL sequences in MRI staging scans.MethodsEighty-four newly diagnosed NPC patients underwent both LAVA-Flex and T1WI-IDEAL sequences during MRI examinations. Two radiologists independently scored the acquisitions of image quality, fat suppression quality, artifacts, vascular and nerve display. The obtained scores were compared using the Wilcoxon signed rank test. According to the signal intensity (SI) measurements, the uniformity of fat suppression, contrast between tumor lesions and subcutaneous fat tissue, and signal-to-noise ratio (SNR) were compared by the paired t-test.ResultsCompared to the T1WI-IDEAL sequence, LAVA-Flex exhibited fewer artifacts (P<0.05), better visualization of nerves and vessels (P<0.05), and performed superior in the fat contrast ratio of the primary lesion and metastatic lymph nodes (0.80 vs. 0.52, 0.81 vs. 0.56, separately, P<0.001). There was no statistically significant difference in overall image quality, tumor signal-to-noise ratio (SNR), muscle SNR, and the detection rate of lesions between the two sequences (P>0.05). T1WI-IDEAL was superior to LAVA-Flex in the evaluation of fat suppression uniformity (P<0.05).DiscussionLAVA-Flex sequence provides satisfactory image quality and better visualization of nerves and vessels for NPC with shorter scanning times
Development of a prognostic nomogram and risk stratification system for upper thoracic esophageal squamous cell carcinoma
BackgroundThe study aimed to develop a nomogram model to predict overall survival (OS) and construct a risk stratification system of upper thoracic esophageal squamous cell carcinoma (ESCC).MethodsNewly diagnosed 568 patients with upper ESCC at Fujian Medical University Cancer Hospital were taken as a training cohort, and additional 155 patients with upper ESCC from Sichuan Cancer Hospital Institute were used as a validation cohort. A nomogram was established using Cox proportional hazard regression to identify prognostic factors for OS. The predictive power of nomogram model was evaluated by using 4 indices: concordance statistics (C-index), time-dependent ROC (ROCt) curve, net reclassification index (NRI) and integrated discrimination improvement (IDI).ResultsIn this study, multivariate analysis revealed that gender, clinical T stage, clinical N stage and primary gross tumor volume were independent prognostic factors for OS in the training cohort. The nomogram based on these factors presented favorable prognostic efficacy in the both training and validation cohorts, with concordance statistics (C-index) of 0.622, 0.713, and area under the curve (AUC) value of 0.709, 0.739, respectively, which appeared superior to those of the American Joint Committee on Cancer (AJCC) staging system. Additionally, net reclassification index (NRI) and integrated discrimination improvement (IDI) of the nomogram presented better discrimination ability to predict survival than those of AJCC staging. Furthermore, decision curve analysis (DCA) of the nomogram exhibited greater clinical performance than that of AJCC staging. Finally, the nomogram fairly distinguished the OS rates among low, moderate, and high risk groups, whereas the OS curves of clinical stage could not be well separated among clinical AJCC stage.ConclusionWe built an effective nomogram model for predicting OS of upper ESCC, which may improve clinicians’ abilities to predict individualized survival and facilitate to further stratify the management of patients at risk
A targetable nanogenerator of nitric oxide for light-triggered cytotoxicity
NSF China [21305116, 21272196, 21072162]; 973 program [2013CB933901]; PCSIRT; NFFTBS [J1310024]; Fundamental Research Funds for the Central Universities [2011121020]Nanoscale-vesicles that can target pathogens are valuable for biomedical applications. In this study, a photo-responsive nanogenerator of nitric oxide (NO) comprised of a hydrophobic core of 3trifluoromethyl- 4-nitroaniline (TFNA) and a hydrophilic shell of mannosylated poly[styrene-alter-(maleic acid)] was constructed to target and kill lectin-expressing cells. The release of NO from the nanogenerator (T@ P-M) was effectively induced by luminol-derived chemiluminescence (CL), leading to high-efficiency killing of Escherichia coli (E. coli) treated with T@ P-M. In addition, the uptake of T@ P-M by Raw 264.7 macrophages was achieved by cell surface lectin-mediated endocytosis, enabling the intracellular release of NO from the internalized T@ P-M upon the induction of extracellular chemiluminescence. Because in vivo-generated CL can overcome the limited penetration of exogenous light into biological tissues, T@ P-M has potential uses as a targetable photo-activatable microbicide to combat pathogens bearing lectins or residing in macrophages
Disentangling superconducting and magnetic orders in NaFe_1-xNi_xAs using muon spin rotation
Muon spin rotation and relaxation studies have been performed on a "111"
family of iron-based superconductors NaFe_1-xNi_xAs. Static magnetic order was
characterized by obtaining the temperature and doping dependences of the local
ordered magnetic moment size and the volume fraction of the magnetically
ordered regions. For x = 0 and 0.4 %, a transition to a nearly-homogeneous long
range magnetically ordered state is observed, while for higher x than 0.4 %
magnetic order becomes more disordered and is completely suppressed for x = 1.5
%. The magnetic volume fraction continuously decreases with increasing x. The
combination of magnetic and superconducting volumes implies that a
spatially-overlapping coexistence of magnetism and superconductivity spans a
large region of the T-x phase diagram for NaFe_1-xNi_xAs . A strong reduction
of both the ordered moment size and the volume fraction is observed below the
superconducting T_C for x = 0.6, 1.0, and 1.3 %, in contrast to other iron
pnictides in which one of these two parameters exhibits a reduction below TC,
but not both. The suppression of magnetic order is further enhanced with
increased Ni doping, leading to a reentrant non-magnetic state below T_C for x
= 1.3 %. The reentrant behavior indicates an interplay between
antiferromagnetism and superconductivity involving competition for the same
electrons. These observations are consistent with the sign-changing s-wave
superconducting state, which is expected to appear on the verge of microscopic
coexistence and phase separation with magnetism. We also present a universal
linear relationship between the local ordered moment size and the
antiferromagnetic ordering temperature TN across a variety of iron-based
superconductors. We argue that this linear relationship is consistent with an
itinerant-electron approach, in which Fermi surface nesting drives
antiferromagnetic ordering.Comment: 20 pages, 14 figures, Correspondence should be addressed to Prof.
Yasutomo Uemura: [email protected]