Oral Sulopenem and Tebipenem for Complicated Urinary Tract Infection and Pyelonephritis in patients with Extended-Spectrum Beta-Lactamase (ESBL)-producing Gram Negative, Susceptible Bacteria

ESBL-producing gram negative Enterobacteria is becoming more prevalent, and carbapenems play a key role in combating against ESBL for complicated urinary tract infections (cUTI). However, carbapenems are only available intravenously in the U.S. FDA is currently reviewing the newly developed oral carbapenems (sulopenem and tebipenem) and have requested additional clinical trial information before granting approval for cUTI. Currently available phase 3 clinical trials for tebipenem and sulopenem are reviewed

A prospective study of artificially sweetened beverage intake and cardiometabolic health among women at high risk

BackgroundArtificially sweetened beverages (ASBs) are commonly consumed and recommended for individuals at high risk for cardiometabolic diseases; however, the health effects of ASBs remain contradictory. Given that cross-sectional analyses are subject to reverse causation, prospective studies with long-term follow-up are needed to evaluate associations between ASBs and cardiometabolic health, especially among high-risk individuals.ObjectiveThe aim of this study was to examine associations of ASB intake and cardiometabolic health among high-risk women with prior gestational diabetes mellitus (GDM).MethodsWe included 607 women with GDM from the Danish National Birth Cohort (DNBC; 1996-2002) who completed a clinical exam 9-16 y after the DNBC pregnancy for the Diabetes & Women's Health (DWH) Study (2012-2014). We assessed ASB intake using FFQs completed during the DNBC pregnancy and at the DWH Study clinical exam. We examined cardiometabolic outcomes at the DWH clinical exam. We estimated percentage differences in continuous cardiometabolic markers and RRs for clinical endpoints in association with ASB intake both during pregnancy and at follow-up adjusted for prepregnancy BMI, diet, and lifestyle factors. Sensitivity analyses to account for reverse causation were performed.ResultsIn pregnancy and at follow-up, 30.4% and 36.4% of women regularly (≥2 servings/wk) consumed ASB, respectively. Consumption of ASBs, both during pregnancy and at follow-up, was associated with higher glycated hemoglobin (HbA1c), insulin, HOMA-IR, triglycerides, liver fat, and adiposity and with lower HDL at follow-up. After adjustment for covariates, particularly prepregnancy BMI, the majority of associations between ASB intake in pregnancy and outcomes at follow-up became null with the exception of HbA1c. ASB intake at follow-up (≥1 serving/d compared with <1 serving/mo) was associated with higher HbA1c (6.5%; 95% CI: 1.9, 11.3; P-trend = 0.007); however, associations were not upheld in sensitivity analyses for reverse causation.ConclusionsAmong Danish women with a history of GDM, ASB intake was not significantly associated with cardiometabolic profiles

Understanding Social Media Users’ Intentions to Disclose Negative Emotions - Dual Persuasion Paths Perspective

This article aims at investigating the influence mechanism of central route factors which guided by negative emotions and peripheral route factors that reflect social environment on the willingness of social media users to disclose negative emotions. By applying the Elaboration Likelihood Model (ELM), combined with use and satisfaction theory, a theoretical model to investigate social media users\u27 willingness to disclose negative emotions is developed and an empirical analysis is conducted. The findings indicate that disclosure of negative emotions in social media is the result of joint decision-making through dual (personal and social environmental) persuasive paths and is mediated by two psychological needs, in which need for negative emotional expression shows a positive effect while need for impression management exhibits a negative effect. Among the central route factors, the intensity of negative emotions gives positive impact on need for negative emotional expression and negatively affects the need for impression management, in turn promoting negative emotional disclosure intention, while the negative emotion regulation ability has the opposite effect. As the peripheral route factor, social support positively affects the need for negative emotional expression, negatively affects the need for impression management, and finally lead to negative emotional disclosure intention. The influence of emotional support is relatively more significant. Limitations and implications for both research and practice are discussed

The complete mitochondrial genome of the Acropora cerealis

In this study, the complete mitogenome sequence of the Acropora cerealis (Acropora), has been sequenced by next-generation sequence method. The overall of A. cerealis mitogenome is 24.88% for A, 14.15% for C, 24.13% for G, and 36.84% for T, as well as 38.28% for low GC. The assembled mitogenome, consisting of 17,940 bp, has unique 13 protein-coding genes (PCGs), 2 transfer RNA genes and 2 ribosomal RNA genes. The complete mitogenome provides essential and important DNA molecular data for further phylogenetic and evolutionary analysis of stony coral phylogeny

22nd annual Applied Statistics Symposium of the International Chinese Statistical Association (ICSA), jointly with the International Society for Biopharmaceutical Statistics (ISBS)

This volume is a unique combination of papers that cover critical topics in biostatistics from academic, government, and industry perspectives. The six sections cover Bayesian methods in biomedical research; Diagnostic medicine and classification; Innovative clinical trials design; Modelling and data analysis; Personalized medicine; and Statistical genomics. The real world applications are in clinical trials, diagnostic medicine and genetics. The peer-reviewed contributions were solicited and selected from some 400 presentations at the annual meeting of the International Chinese Statistical Association (ICSA), held with the International Society for Biopharmaceutical Statistics (ISBS). The conference was held in Bethesda in June 2013, and the material has been subsequently edited and expanded to cover the most recent developments