Avaliação das alterações hemodinâmicas e do sensório em pacientes submetidos à rinoplastia estética sob anestesia local

OBJECTIVE: To determine the extension of hemodynamic changes in patients submitted to rhinoplasty under local anesthesia.MATERIALS AND METHODS: One hundred consecutive patients were investigated. They were operated between September 1988 and February 1989 at Clinica Planas,Barcelona, Spain. The evaluation included continuous monitoring of patients’ heart rate, arterial pressure, oxygen saturation, cardiac rhythm, and consciousness level throughout the procedure.RESULTS: The curve of arterial pressure variation was in accordance with the adrenaline peak, when injected subcutaneously (slower). This underscores theimportance of waiting at least 20 minutes before starting the procedure, in order to have the best vasoconstrictive effect. Sinus tachycardia is the most remarkable rhythmalteration observed in this study. It is present in almost all patients at the adrenaline peak. Hemodynamic alterations, mainly arterial hypertension, must be carefully observed, especially on predisposed patients.CONCLUSION: When the patient receives adequate preoperative care and intraoperative monitoring, rhinoplasty under local anesthesia is a safe procedure.OBJETIVO: Determinar as alterações hemodinâmicas em pacientes submetidos à rinoplastia estética sob anestesia local.MÉTODO: Foram investigados 100 pacientes consecutivos submetidos à rinoplastia estética sob anestesia local e sedação, no período de setembro de 1988 a fevereiro de 1989, na Clínica Planas, Barcelona, Espanha. A avaliação foi feita pela monitorização da freqüência cardíaca, pressão arterial sistêmica, saturação do oxigênio, ritmo cardíaco e nível de consciência do paciente, continuamente, do início ao término da intervenção.RESULTADOS: A curva de variação da pressão arterial esteve de acordo com o pico de ação da adrenalina, quando injetada subcutaneamente (mais lento), demonstrando a importância de esperar ao redor de 20 minutos após a injeção local para a obtençãode um efeito vasoconstritor ótimo. A taquicardia sinusal é a alteração de ritmo mais marcante neste estudo, aparecendo no pico de ação da adrenalina em quase todos os pacientes. As alterações hemodinâmicas, notadamente a hipertensão arterial, devem merecer cuidados, principalmente em pacientes predispostos.CONCLUSÃO: Quando o paciente está adequadamente assistido e monitorizado, a rinoplastia sob anestesia local é um procedimento seguro

A Surface Energy Transfer Nanoruler for Measuring Binding Site Distances on Live Cell Surfaces

Measuring distances at molecular length scales in living systems is a significant challenge. Methods like Forster resonance energy transfer (FRET) have limitations due to short detection distances and strict oriental ions. Recently, surface energy transfer (SET) has been used in bulk solutions; however, it cannot be applied to living systems. Here, we have developed an SET nanoruler, using aptamer-gold nanoparticle conjugates with different diameters, to monitor the distance between binding sites of a receptor on living cells. The nanoruler can measure separation distances well beyond the detection limit of FRET. Thus, for the firs: time, we have developed an effective SET nanoruler for live cells with long distance, easy construction, fast detection, and low background. This is also the first time that the distance between the aptamer and antibody binding sites in the membrane protein PTK7 was measured accurately. The SET nanoruler represents the next leap forward to monitor structural components within living cell membranes.Chinese Government ; Academic Women Madelyn Lockhart Dissertation Fellowship ; NIH ; NSF ; National Basic Research Program of China [2007CB935603, 2010CB732402]; [2009ZX10004-312

A portable battery monitor for the in in natural waters -powered flow injection situ analysis of nitrate

1993 A portable battery-powered flow injection monitor for the in situ analysis of nitrate in natural waters

Catalytically active gold on ordered titania supports

Almost two decades have passed since supported An nanoparticles were found to be active for CO oxidation. This discovery inspired extensive research addressing the origin of the unique properties of supported Au nanoparticles, the design and synthesis of potentially technical An catalysts, and the extension of An catalysis to other reactions. This tutorial review summarises the current understanding of the origin of the unique properties of titania-supported ALL catalysts for carbon monoxide oxidation. The key issues of catalysis by nanostructured An, effects of oxide support and active site/structure, especially those provided from model studies are discussed in detail. The successful synthesis of a highly catalytically active gold bilayer may lead to the design and synthesis of practically active Au nanofilm catalysts.Department of Energy ; Office of Basic Energy ; Division of Chemical Sciences ; Robert A. Welch Foundatio

Promotional Effects of Au in Pd-Au Catalysts for Vinyl Acetate Synthesis

Silica Supported Pd-Au bimetallic catalysts are highly selective for the acetoxylation of ethylene to vinyl acetate (VA). In this study we have used model catalysts consisting of planer surfaces and supported nanoparticles to investigate the promotional effects of Au in Pd-Au bimetallic catalysts. Low energy ion scattering spectroscopy, low energy electron diffraction, X-ray photoelectron spectroscopy, infrared reflection adsorption spectroscopy, and temperature-programmed desorption et al, were used to characterize the model systems. The catalytic performance for acetoxylation of ethylene to VA was examined for these model surfaces. In this paper, We summarize the Current understanding of the promotional effects of Au in Pd-Au bimetallic catalysts for VA synthesis. The key results are that An atoms break contiguous Pd atom ensembles at the surface into isolated Pd monomers. The absence of contiguous Pd sites significantly reduces the formation of combustion by-products and Suppresses the poison effects of CO, thus enhancing the VA formation selectivity and activity.Department of Energy, Office of Basic Energy, Division of Chemical Science ; Robert A. Welch Foundatio

INFLUENCE OF LINEAR ALKYLBENZENE SULFONATE (LAS) AS ORGANIC COSOLVENT ON LEACHING BEHAVIOR OF PCDD/FS FROM FLY-ASH AND SOIL

The leaching of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) was measured in soil and standard fly ash column eluted with pure water and linear alkylbenzene sulfonate (LAS)- water. The data obtained were used to evaluate the leachability of PCDD/Fs from waste dump like incineration residual slag and fly ash deposition. The leaching rate was shown to be increased significantly by using LAS water. The leachate contents of PCDD/Fs were above their known water solubility. Concentration of PCDD/Fs in the leachates as well as the relative leaching (calculated on the fly ash content) increased with increasing chlorinating degree and decreasing water solubility. LAS above the critical micelle concentration (CMC) probably enhances PCDD/Fs solubility

Cutaneous lupus erythematosus after treatment with paclitaxel and bevacizumab for metastatic breast cancer: a case report

Abstract Introduction The monoclonal anti-vascular endothelial growth factor antibody bevacizumab is increasingly used in the treatment of several malignant tumors. The usual side effects of this drug are hypertension and proteinuria. Paclitaxel is widely used in the treatment of breast cancer and head and neck carcinomas. Neither of these two drugs typically causes skin disorders. Paclitaxel-related cutaneous lupus erythematosus has been described before, but in earlier cases patients had a history of autoimmune disease. Case presentation We report a case of a 65-year-old Caucasian woman who presented with cutaneous lupus erythematosus after receiving paclitaxel-bevacizumab combination treatment as first-line therapy for metastatic breast cancer. Her cutaneous symptoms and increased serum anti-SSA and anti-SSB antibodies disappeared shortly after the discontinuation of therapy. Conclusion We conclude that cutaneous lupus erythematosus can also be seen in patients without earlier anamnesis of autoimmune disorders and that, furthermore, bevacizumab might cause atypical cutaneous side effects.</p

CRYSTAL ORIENTATION EFFECTS DURING FABRICATION OF SINGLE OR MULTI-CRYSTAL NB SRF CAVITIES*

Abstract Single and large-grain Nb SRF cavities are of interest due to possible reduction of cost and problems associated with inconsistent texture and surface finish among batches of rolled polycrystalline Nb sheet. The effect of crystal orientation on dislocation density, surface quality, and recrystallization after plastic deformation and e-beam welding was investigated, as understanding of their interrelations is needed. These were evaluated for three samples of different orientations at steps similar to those in typical cavity forming, with deformation modeled using a crystal plasticity approach. Initial dislocation density was higher than expected, increased with deformation, after welding was reduced in recovered areas, and was similar to initial density in recrystallized grains; there was also evidence that Nb has a higher tolerance for dislocations than other metals. Surface quality depends on a complex relation of crystal orientation, slip system activity, and prior surface treatment. Recrystallization nucleated outside the melt pool, and the new orientations grew both epitaxially into the weld as it solidified, and away until heat and time were insufficient to continue growth

Sulfur K-Edge XAS and DFT Calculations on [Fe4S4]2+Clusters: Effects of H-bonding and Structural Distortion on Covalency and SpinTopology

Sulfur K-edge X-ray absorption spectroscopy of a hydrogen-bonded elongated [Fe{sub 4}S{sub 4}]{sup 2+} cube is reported. The data show that this synthetic cube is less covalent than a normal compressed cube with no hydrogen bonding. DFT calculations reveal that the observed difference in electronic structure has significant contributions from both the cluster distortion and from hydrogen bonding. The elongated and compressed Fe{sub 4}S{sub 4} structures are found to have different spin topologies (i.e., orientation of the delocalized Fe{sub 2}S{sub 2} subclusters which are antiferromagnetically coupled to each other). It is suggested that the H-bonding interaction with the counterion does not contribute to the cluster elongation. A magneto-structural correlation is developed for the Fe{sub 4}S{sub 4} cube that is used to identify the redoxactive Fe{sub 2}S{sub 2} subclusters in active sites of HiPIP and ferredoxin proteins involving these clusters