Thermoregulatory responses of lactating dairy cows to an acute heat stress after a pharmacologically-induced LH surge

The objective of this study was to develop an in vivo model to assess thermoregulatory response of lactating dairy cows to heat stress. Hyperthermia occurring for 10 to 12 hours after LH surge reduces quality of maturing oocyte, thereby reducing fertility. Between the months of February through May, cows were transported to a climate-controlled facility and maintained at a temperature-humidity index (THI) of 65.9 ± [plus or minus] 0.2 (thermoneutral) or exposed to increases in THI of 0.8 ± 0.1 units per hour (heat stress) for 12 hours before rapidly cooling to thermoneutral conditions. Mixed model regressions with repeated measures were used to test respiration rates (RR) and rectal temperature (RT). Within 40 and 110 min of increasing THI, RR increased in a quadratic fashion (P \u3c [less than] 0.001); RT increased by 0.04 ± 0.1° [degree] C (P \u3c 0.001) per unit THI. Changes in RR lagged THI and preceded rises in RT by 30 min. Average THI 3-days prior to treatment influenced changes in RR (P = [equal] 0.050) and RT (P \u3c 0.001). Increased RR was more noticeable in heat-stressed cows when prior THI was in the 40s than low 60s. Rectal temperature of heat-stressed cows was 0.8 ± 0.02°C lower when prior THI was in the 40s versus low 60s. Progesterone and LH levels before treatment were predictive of thermoregulatory response in heat-stressed cows. Rapid cooling decreased RR by 0.6 ± 0.1 bpm (P \u3c 0.001) and RT by 0.02 ± 0.002°C per min (P \u3c 0.002). Speed and magnitude of thermoregulatory changes to an acute heat stress and after sudden cooling emphasizes the importance of strategic cooling before ovulation. Efforts to do so when prior THI approaches levels expected to induce mild stress are especially important. Respiration rate is a useful indicator of the degree of hyperthermia a lactating cow is experiencing during an acute heat stress event

Examining the efficacy of a digital version of the Self-Administered Interview

Objectives. The Self-Administered Interview (SAI©) is an investigative tool designed to facilitate the reporting of comprehensive initial statements by witnesses. Given increasing use of technology to communicate, many witnesses may prefer to provide investigators with accounts of what they have seen using online or mobile reporting platforms. Research shows that the SAI© elicits more accurate information from witnesses than other reporting formats. To date, however, the SAI© has only been tested in a paper-based format. The aim of the current research was to examine whether the benefits of the SAI© for witness reporting extend to digital reporting formats. Method: In two experiments, we examined whether completing the SAI© on a computer or mobile device (as opposed to using a paper-based format) had any effect on the quantity or quality of information reported by mock witnesses. We also assessed whether the format of the initial report had any impact on performance in a delayed recall test. Hypotheses. Based on available research on use of technology, we expected that witness accounts would be shorter when provided via mobile devices than via other formats. Drawing on past research outlined in the Introduction, we predicted that less detailed initial accounts would affect the quality of subsequent accounts. Results. We found no differences between computer, mobile, or paper-based formats with respect to the quantity or quality of information reported in the SAI© or content of follow-up reports collected oneweek later. Conclusion. The findings suggest that administering the SAI© in online or mobile formats is unlikely to be detrimental to witness reporting. Given the time and resource costs associated with paper forms, as well as the additional functionality that digital presentation may afford, a digital SAI© may prove to be a useful investigative tool

Engaging with First Responders to Prevent Falls in Older Adults

In order to further explore the circumstances of falls in the City of Novato’s older adults age 60 and over Novato Fire Protection District (NFPD) partnered with Dominican University Occupational Therapy Department to conduct a study with the support of County of Marin Mental Health Services Act funds. The following were the goals of this study: Identify fall risk factors in community-dwelling older adults. Understand the experiences of older adults who have fallen. Determine whether there is a relationship between falls and depression in older adults. Examine first responder experiences with fall-related calls in older adults. Identify approaches to prevent falls in older adults. Data sources included Patient Care Reports (PCRs) completed by EMS first responders with narratives coded by the researchers, two focus groups conducted with older adults living in adult care facilities, telephone interviews with four older adults residing at home in the community and a focus group with NFPD first responders

Bridging text spotting and SLAM with junction features

Navigating in a previously unknown environment and recognizing naturally occurring text in a scene are two important autonomous capabilities that are typically treated as distinct. However, these two tasks are potentially complementary, (i) scene and pose priors can benefit text spotting, and (ii) the ability to identify and associate text features can benefit navigation accuracy through loop closures. Previous approaches to autonomous text spotting typically require significant training data and are too slow for real-time implementation. In this work, we propose a novel high-level feature descriptor, the “junction”, which is particularly well-suited to text representation and is also fast to compute. We show that we are able to improve SLAM through text spotting on datasets collected with a Google Tango, illustrating how location priors enable improved loop closure with text features.Andrea Bocelli FoundationEast Japan Railway CompanyUnited States. Office of Naval Research (N00014-10-1-0936, N00014-11-1-0688, N00014-13-1-0588)National Science Foundation (U.S.) (IIS-1318392

Implementing a Novel Facility-Community Intervention for Strengthening Integration of Infant Nutrition and Family Planning in Mara and Kagera, Tanzania

Tanzania has high fertility, low contraceptive prevalence and low exclusive breastfeeding (EBF). The Lake Zone, including Mara and Kagera regions, leads the country in total fertility; use of the lactational amenorrhea method (LAM) is negligible. This pre-/post-study explored the effects of a multi-level facility and community intervention (service delivery support, community engagement, media and LAM tracking) to integrate maternal and infant nutrition and postpartum family planning (FP) within existing health contacts. Mixed methods were used, including service statistics, exit interviews, patient-tracking tools for community health workers, client self-tracking tools, supervision data, focus group discussions and in-depth interviews. Results are presented using the reach, effectiveness, adoption, implementation and maintenance (RE-AIM) implementation science framework. The intervention reached primarily the second and fourth wealth quintiles, increased FP and EBF at six weeks postpartum. LAM was very acceptable, provided an entry point for FP conversations and for addressing misconceptions, and reinforced EBF practices. Partners felt encouraged to support spousal nutrition, breastfeeding and FP. Higher adoption in Kagera may be influenced by performance-based financing. The intervention was implemented with generally high fidelity. Maintenance data reflected stakeholder interest in continuing the intervention. A multi-level facility and community intervention was feasible to implement and likely contributed to improved EBF practices and FP uptake, including LAM use

Prescription Opioid Use and Concurrent Psychotropic Drug Use During Pregnancy: A Population-Based Retrospective Cohort Study Utilizing Linked Administrative Data

Introduction It is important to investigate the use of prescription opioids during pregnancy to gain insight into the potential impact of maternal opioid exposure during pregnancy on children. We report the prevalence of prescription opioid use and concurrent psychotropic drug use in a large, Canadian population-based cohort of pregnant women. Objectives and Approach Using population-level linked administrative data from a universal health care system, this study included all women with a live birth in Manitoba from 1996 to 2014. Dispensing of opioids was determined from prescription drug data. Patterns of prescription opioids dispensed to pregnant women were investigated by demographic characteristics, region of residence, and socioeconomic status. Concurrent psychotropic therapies were also measured. These data address limitations associated with re-call bias, cilitate longitudinal analaysis, and allow the investigation of rare outcomes, difficult to study using other data sources. Results In a large population level sample of pregnancies (N=245,784), 2.43% of pregnancies were exposed to 2+ dispensations of opioids. An additional 4.95% of pregnancies recorded at a single opioid dispensation. Compared to women who were not dispensed any opioid prescriptions, the proportion of opioid exposed pregnancies who were also prescribed anti-depressants (SSRI/SNRI) was sevenfold higher (22.5% vs 3.05%). The same pattern was found for anxiolytics (37.2% vs 1.5%) and antipsychotics (3.5% vs 0.34%). Conclusion/Implications These data demonstrate high proportions of women were dispensed opioids during pregnancy. Further research should be done on the short term and long term effects of these medications on infants and children. Moreover, these results highlight the need for further investigation into the effects of exposure to multiple psychotropic drug

In-Utero SSRI and SNRI Exposure and the Risk of Long Term Adverse Mental and Educational Outcomes in Children: A Population-Based Retrospective Cohort Study Utilizing Linked Administrative Data

Introduction Few studies are capable of investigating the impact of untreated maternal depression versus in-utero antidepressant exposure on long-term effects on children. Previous studies are limited by confounding by indication and are unable to follow children over time to accurately investigate long term outcomes present in childhood and adolescence. Objectives and Approach We utilize linkable administrative data to facilitate longitudinal analysis to investigate mental and educational outcomes in children exposed to in utero antidepressants. Using population-level linked administrative data from a universal health system, this study included all mother-newborn dyads in Manitoba (born 1996 to 2009, with follow-up through 2014). High Dimensional Propensity Scores and inverse probability treatment weighting were used to address confounding by indication and disease severity.Cox Proportional Hazard Regression models were used to estimate risk of mood and anxiety disorder in children and educational outcomes. Results Asymmetric trimming of the study cohort resulted in a total of 4998 mother-child dyads; 4159 children whose mothers did not use SSRIs/SNRIs during pregnancy and 839 children who were exposed to 2+ prescriptions in-utero. Use of SSRIs/SNRIs during pregnancy was not associated with an increased risk of mood/anxiety disorder in children HR 1.32 (95% CI 0.67 to 2.62). Initial results on the association between in-utero antidepressant use and early childhood development index (EDI) scores indicate no impact on school readiness (31.9% vs 29.3%), or scores on standardized tests of literacy and numeracy in Grade 3 (28.4% meeting expectation versus 31.4%) and in Grade 7 (68.8% versus 70.0%). Conclusion/Implications Administrative data facilitate investigation into an important clinical concern. These data provide robust evidence demonstrating in a large population based sample, in utero exposure to serotonergic antidepressants compared with no exposure does not increase risk of the onset of mood and anxiety disorders and adverse educational outcomes in children

In-Utero SSRI and SNRI Exposure and the Risk of Neurodevelopmental Disorders in Children: A Population-Based Retrospective Cohort Study Utilizing Linked Administrative Data

Introduction Many studies demonstrating an association between in utero exposure to serotonergic antidepressants and higher risk of neurodevelopmental disorders in children are confounded by history of maternal depression and disease severity. We conducted a population-based analysis of women diagnosed with mood/anxiety disorder, a patient population for whom pharmacotherapy is clearly indicated. Objectives and Approach Using linked population-based administrative data, we identified all mother-newborn pairs in Manitoba (born 1996 to 2009, with follow-up through 2014). High dimensional propensity scores and inverse probability treatment weighting were used to address confounding by indication and disease severity. The final trimmed cohort consisted of mothers who were diagnosed with a mood/anxiety disorder from 90 days prior to conception until delivery (n=4995). Cox Proportional Hazard Regression models were used to estimate risk of Autism Spectrum Disorder, epilepsy and attention deficit hyperactivity disorder (ADHD) in offspring. In addition to clinical data, we used novel education data to define outcomes in children. Results Among the cohort of mothers diagnosed with a mood/anxiety disorder during pregnancy or up to 90 days before, 16.8% received at least two dispensations of an SSRI or SNRI during pregnancy. We did not observe an association between use of SSRIs/SNRIs during pregnancy and increased risk of Autism Spectrum Disorder (hazard ratio 0.92; 95% CI 0.42 to 2.03), epilepsy (hazard ratio 1.21; 95% CI 0.48 to 3.05), or ADHD (hazard ratio 1.13, 95% CI 0.78 to 1.64) among offspring. Conclusion/Implications In the absence of randomized control trials, large observation studies using sophisticated data analysis are the gold standard of evidence to help patients and clinicians making the decision to continue antidepressant use during pregnancy. Results of this study reassure women for whom the medication is clinically indicated