A Community-based Epidemiological Study on non-fatal Road Traffic Accidents in Puducherry, South India

Introduction: Road traffic accidents are the sixth leading cause of death in India with a greater share of hospitalization, disabilities, deaths and socio-economic losses. Objective: To identify the pattern of non-fatal road traffic accidents, socio-demographic profile of accident victims and antecedent factors influencing these road traffic injuries. Method: A cross-sectional study was conducted for six months in Puducherry. From existing 27 wards of Lawspet, six wards were selected by simple random sampling technique and all the households in selected wards were included. The minimum required sample size was estimated to be 165 by considering prevalence of non-fatal road traffic accidents in Puducherry as 5.6%. Face-to-face interview with a semi-structured questionnaire was used for data collection. Data entry and analysis were performed using Epi-data manager 4.2.0. Results: Total 169 accident victims were included in the study from the households of selected wards. Mean age of the accident victims was found to be 36.2 (11.4) years. Two‑wheeler accidents accounted for 144 (85.2%) and 123 (72.7%) accident victims were drivers at the time of accident. Majority (95.1 %) of the victims did not wear helmet while driving two-wheelers and none of the four-wheel drivers/pillions wore seat belts. Majority of the accidents occurred on usual tar roads 116 (68.6%) and 42 (24.9%) on highways. 102 (60.4%) accidents occurred in bi-directional roads.Conclusion: Simple or minor injuries were high compared to serious injuries requiring hospitalization. Majority of the accidents occurred during Fridays, Saturdays and Sundays. The accidents exhibited a bimodal distribution with day and night time

Multi centre study from Malaysia on student preparedness for clinical learning- Perspectives of lecturers and students from medicine, pharmacy and allied health sciences

Objectives: To determine the characteristics important in health profession students’ preparedness for clinical learning from the perspectives of lecturers and studentsMethods: A descriptive cross sectional study was conducted at International Medical University, Perdana University and Monash University in Malaysia. All lecturers involved in preparing students for clinical learning in medicine, dentistry, nursing, pharmacy, nutrition and dietetics, chiropractic and Chinese medicine and immediate preclinical students were invited. We explored views regarding student preparedness on knowledge and understanding, willingness to learn, professionalism, communication and interaction, personal attributes and interpersonal skills rated on a 7 point Likert scale in a questionnaire with 62 items.Results: A total of 187 lecturers and 317 students participated. Fifty percent of lecturers had 5-9year of experience. Neither the lecturers nor the students had differentiated or identified specific characteristics as more important over the others but rated all 62 items as important (score >5) for training. The mean score of the 6 themes for lecturers and students respectively were for knowledge and understanding (5.44,5.09), willingness (5.95,5.51), professionalism (5.89,5.49), communication and interaction (5.54,5.34), personal attributes (5.54,5.35) and interpersonal skills (5.54,5.38). Interesting suggestions such as promotion of inter-professional learning among student from different disciplines, case discussions as a team with other professional categories, self reflection for lecturers regarding their attitudes towards students and teaching methods had been stated by students.Conclusions: Both lecturers and students deem that the knowledge and understanding is not the most important characteristic that makes a student better prepared for clinical learning.

Effects of Cyclic Strain and Growth Factors on Vascular Smooth Muscle Cell Responses

Under physiological and pathological conditions, vascular smooth muscle cells (SMC) are exposed to different biochemical factors and biomechanical forces. Previous studies pertaining to SMC responses have not investigated the effects of both factors on SMCs. Thus, in our research we investigated the combined effects of growth factors like Bfgf (basic fibroblast growth factor), TGF-β (transforming growth factor β) and PDGF (platelet-derived growth factor) along with physiological cyclic strain on SMC responses. Physiological cyclic strain (10% strain) significantly reduced SMC proliferation compared to static controls while addition of growth factors bFGF, TGF-β or PDGF-AB had a positive influence on SMC growth compared to strain alone. Microarray analysis of SMCs exposed to these growth factors and cyclic strain showed that several bioactive genes (vascular endothelial growth factor, epidermal growth factor receptor, etc.) were altered upon exposure. Further work involving biochemical and pathological cyclic strain stimulation will help us better understand the role of cyclic strain and growth factors in vascular functions and development of vascular disorders

Impact of primary kidney disease on the effects of empagliflozin in patients with chronic kidney disease: secondary analyses of the EMPA-KIDNEY trial

Background: The EMPA KIDNEY trial showed that empagliflozin reduced the risk of the primary composite outcome of kidney disease progression or cardiovascular death in patients with chronic kidney disease mainly through slowing progression. We aimed to assess how effects of empagliflozin might differ by primary kidney disease across its broad population. Methods: EMPA-KIDNEY, a randomised, controlled, phase 3 trial, was conducted at 241 centres in eight countries (Canada, China, Germany, Italy, Japan, Malaysia, the UK, and the USA). Patients were eligible if their estimated glomerular filtration rate (eGFR) was 20 to less than 45 mL/min per 1·73 m2, or 45 to less than 90 mL/min per 1·73 m2 with a urinary albumin-to-creatinine ratio (uACR) of 200 mg/g or higher at screening. They were randomly assigned (1:1) to 10 mg oral empagliflozin once daily or matching placebo. Effects on kidney disease progression (defined as a sustained ≥40% eGFR decline from randomisation, end-stage kidney disease, a sustained eGFR below 10 mL/min per 1·73 m2, or death from kidney failure) were assessed using prespecified Cox models, and eGFR slope analyses used shared parameter models. Subgroup comparisons were performed by including relevant interaction terms in models. EMPA-KIDNEY is registered with ClinicalTrials.gov, NCT03594110. Findings: Between May 15, 2019, and April 16, 2021, 6609 participants were randomly assigned and followed up for a median of 2·0 years (IQR 1·5–2·4). Prespecified subgroupings by primary kidney disease included 2057 (31·1%) participants with diabetic kidney disease, 1669 (25·3%) with glomerular disease, 1445 (21·9%) with hypertensive or renovascular disease, and 1438 (21·8%) with other or unknown causes. Kidney disease progression occurred in 384 (11·6%) of 3304 patients in the empagliflozin group and 504 (15·2%) of 3305 patients in the placebo group (hazard ratio 0·71 [95% CI 0·62–0·81]), with no evidence that the relative effect size varied significantly by primary kidney disease (pheterogeneity=0·62). The between-group difference in chronic eGFR slopes (ie, from 2 months to final follow-up) was 1·37 mL/min per 1·73 m2 per year (95% CI 1·16–1·59), representing a 50% (42–58) reduction in the rate of chronic eGFR decline. This relative effect of empagliflozin on chronic eGFR slope was similar in analyses by different primary kidney diseases, including in explorations by type of glomerular disease and diabetes (p values for heterogeneity all >0·1). Interpretation: In a broad range of patients with chronic kidney disease at risk of progression, including a wide range of non-diabetic causes of chronic kidney disease, empagliflozin reduced risk of kidney disease progression. Relative effect sizes were broadly similar irrespective of the cause of primary kidney disease, suggesting that SGLT2 inhibitors should be part of a standard of care to minimise risk of kidney failure in chronic kidney disease. Funding: Boehringer Ingelheim, Eli Lilly, and UK Medical Research Council

Association of socio-demographic determinants with quality of life among road traffic accident victims

Background: Road traffic accidents are the sixth leading cause of death in India with a greater share of hospitalization, disabilities, deaths, and socio-economic losses. Objectives: To assess the socio-demographic determinants associated with quality-of-life among road traffic accident victims. Methodology: A community-based, longitudinal study was conducted for 2 years in South India. Simple random sampling was employed to include 169 accident victims. Baseline data were collected with a semi-structured questionnaire on socio-demographic details and using SF-32. Follow-up was at the 6th and 12th month from the day of accident. Data entry and analysis were performed using Epi-data manager 4.2.0. Written informed consent from each participant was sought. Ethical clearance was obtained. Results: The mean ± standard deviation age of the subjects was found to be 36.2 ± 11.4 years. The results of the study showed that there was a statistically significant incremental change in quality of life among the accident survivors at baseline, 6 and 12 months (P < 0.05). Socio-economic determinants such as education, occupation, marital status, and religion were found to be associated with different domains of quality of life. (P < 0.05). Conclusion: The improvement in the quality of life of the victims over 1-year period was found to be significant

Not Available

Not AvailableThe 4 (L) distributory of Pollachi main canal, Parambikulam-Aliyar-Palar (PAP) basin has been selected for an in-depth water management study. The project area has been divided into two zones namely, A zone and B zone. Each zone would get water from the canal system once in every two years. From the analysis of rainfall data of the rain gauge stations located in Parambikulam-Aliyar-Palar basin, it was observed that there was a wide temporal and spatial variability in annual rainfall over the years. The lowest annual rainfall recorded was 210.6 mm (over the plain) in 2003 and the highest of 5346.4 mm (in the hills) in 2007. The average annual rainfall for the period 1988-2010 was 1372.1 mm. The irrigation water requirement for the crops grown in the 4 (L) distributory was estimated using AquaCrop3.1 model for the years 2000-2010. The total irrigation water requirement during deficit rainfall year (2002) was 58.4 percent which is higher compared to normal year (2008). During the excess rainfall year (2007), the demand was 5.32 percent lower than the normal year demand. Therefore, the conjunctive use management of surface and groundwater resources in a command area can play a significant role in managing water by distributing the water throughout the season, while also maintaining the long-term sustainability of groundwater resources.Not Availabl

ELISA detection of SARS-CoV-2 antibodies in saliva

To facilitate containment of the COVID-19 pandemic currently active in the United States and across the world, options for easy, non-invasive antibody testing are required. Here we have adapted a commercially available, serum-based enzyme-linked immunosorbent assay (ELISA) for use with saliva samples, achieving 84.2% sensitivity and 100% specificity in a set of 149 clinical samples. This strategy will enable widespread, affordable testing for patients who experienced this disease, whilst minimizing exposure risk for healthcare workers