Medieval Jewry in Northern France

Originally published in 1974. Focusing on a set of Jewish communities, Robert Chazan tells how, by the eleventh century, French Jews had created for themselves a role as local merchants and moneylenders in adapting to the political, economic, and social limits imposed on them. French society, striving to become more powerful and civilized, was willing to extend aid and protection to the Jews in return for general stimulation of trade and urban life and for the immediate profit realized from taxation. While the authorities were relatively successful in protecting the Jews from others, there was no power to impose itself between the Jews and their protectors. The political and social well-being of the Jews was, therefore, dependent on the will of the governing authorities who taxed their holdings and regulated their activities. During the twelfth and thirteenth centuries, the position of the Jews was constantly under attack by reform elements in the church concerned with Jewish moneylending and blasphemous materials in Jewish books; these reformers were eventually devoted to a serious missionizing effort within the Jewish community. The Jews' situation was further complicated by deep popular animosity, expressing itself in a damaging set of slanders and occasionally in physical violence. Despite the impressive achievements of the Jews in medieval northern France, by the thirteenth century their community was increasingly constricted; and in 1306, they were expelled from royal France by Philip IV. Overcoming the handicap of a lack of copious source material, Chazan analyzes the Jews' political status, their relations with key elements of Christian society, their demographic development, their economic outlets, their internal organization, and their attitudes toward the Christian environment. As it highlights aspects of French society from an unusual perspective, Medieval Jewry in Northern France should be of special interest to the historian of medieval France as well as to the student of Jewish history. This story is also significant for all who are fascinated by the capacity of human groups to respond and adapt creatively to a hostile and limiting environment

Influence of inhaler and fine particle on efficacy of inhalation therapy in COPD

Farmakoterapia stosowana drogą inhalacyjną wykorzystuje efekt podania leku bezpośrednio do narządu docelowego. Umożliwia to podanie bardzo małej dawki leku, która wywiera efekt kliniczny porównywalny z terapią doustną przy wielokrotnie mniejszym efekcie toksycznym. Niemniej, także w terapii inhalacyjnej istnieją czynniki ograniczające dostęp molekuł leku do receptorów narządów docelowych. Dostarczenie pożądanej dawki leku z inhalatora do płuc zależy od typu inhalatora (ciśnieniowy, proszkowy), jego charakterystyki (opór wewnętrzny, średnica cząstek i dystrybucja ich poszczególnych frakcji w generowanym aerozolu), warunków termicznych powietrza oraz od zdolności inhalacyjnych samego chorego. Zastosowanie inhalatorów suchego proszku (DPI) dzięki uwalnianiu dawki leku wdechem wyeliminowało występujący u wielu chorych problem koordynacji wdechu z momentem uwolnienia aerozolu z inhalatora. Poszczególne inhalatory DPI różnią się jednak istotnie pod względem możliwości ich optymalnego stosowania przez chorych na obturacyjne choroby układu oddechowego. Z tego powodu powinny być z rozwagą dobierane do potrzeb i możliwości każdego chorego.Orally inhaled products delivered via inhalation exert their effect directly to the target organ. This allows to administer a very low dose of a drug compared with an oral route with similar clinical effect and significantly reduced toxicity. However inhalation therapy is also limited by several factors. Delivery of the desired dose of the drug to the airways depends on a type of the inhaler — pressurised metered-dose inhaler (pMDI) or dry powder inhaler (DPI), inhaler characteristics (low or high internal resistance, diameter of particles and distribution of the generated aerosol fine particles), thermal conditions of air, and ability of patient to generate sufficient inspiratory flow (for DPI) or to coordinate actuation with inhalation (for pMDI). Unlike pMDIs, DPIs are breath- -actuated, hence avoiding the need for the patient to coordinate actuation with inspiration. Furthermore, DPIs are propellant-free and do not produce the cold sensation on inhalation. Currently available DPIs vary widely in design, operating characteristics and performance. And poor inhalation technique may compromise treatment efficacy. Hence, there is a clear need for a careful selection of DPIs for different patient groups, including children, elderly patients and those with severe airway obstruction

The Impact of a Community-based Pilot Health Education Intervention for Older People as Caregivers of Orphaned and Sick Children as a Result of HIV and AIDS in South Africa

The increasing HIV and AIDS epidemic in South Africa poses a substantial burden to older people, in particular older women who mainly provide care for sick adult children and their grandchildren who have become orphaned and rendered vulnerable by the death or illness of their parents. In this study, 202 isiXhosa speaking older caregivers from Motherwell in the Eastern Cape Province of South Africa were trained to provide care for grandchildren and adult children living with HIV or AIDS. Based on a community needs assessment, a health education intervention comprising four modules was designed to improve skills and knowledge which would be used to assist older people in their care-giving tasks. Some topics were HIV and AIDS knowledge, effective intergenerational communication, providing home-based basic nursing care, accessing social services and grants, and relaxation techniques. Structured one-on-one interviews measured differences between pre-intervention and post-intervention scores among those who attended all four modules vs. those that missed one or more of the sessions. The results demonstrated that older people who participated in all four workshops perceived themselves more able and in control to provide nursing care. The participants also showed a more positive attitude towards people living with HIV or AIDS and reported an increased level of HIV and AIDS knowledge. The results provided valuable information upon which the development of future interventions may be based and psychosocial and structural needs of the older caregivers may be addressed by relevant stakeholders

Single-cell RNA sequencing of liver fine-needle aspirates captures immune diversity in the blood and liver in chronic hepatitis B patients

Background and Aims: HBV infection is restricted to the liver, where it drives exhaustion of virus-specific T and B cells and pathogenesis through dysregulation of intrahepatic immunity. Our understanding of liver-specific events related to viral control and liver damage has relied almost solely on animal models, and we lack useable peripheral biomarkers to quantify intrahepatic immune activation beyond cytokine measurement. Our objective was to overcome the practical obstacles of liver sampling using fine-needle aspiration and develop an optimized workflow to comprehensively compare the blood and liver compartments within patients with chronic hepatitis B using single-cell RNA sequencing. Approach and Results: We developed a workflow that enabled multi-site international studies and centralized single-cell RNA sequencing. Blood and liver fine-needle aspirations were collected, and cellular and molecular captures were compared between the Seq-Well S3 picowell-based and the 10× Chromium reverse-emulsion droplet–based single-cell RNA sequencing technologies. Both technologies captured the cellular diversity of the liver, but Seq-Well S3 effectively captured neutrophils, which were absent in the 10× dataset. CD8 T cells and neutrophils displayed distinct transcriptional profiles between blood and liver. In addition, liver fine-needle aspirations captured a heterogeneous liver macrophage population. Comparison between untreated patients with chronic hepatitis B and patients treated with nucleoside analogs showed that myeloid cells were highly sensitive to environmental changes while lymphocytes displayed minimal differences. Conclusions: The ability to electively sample and intensively profile the immune landscape of the liver, and generate high-resolution data, will enable multi-site clinical studies to identify biomarkers for intrahepatic immune activity in HBV and beyond.</p

Medieval stereotypes and modern antisemitism

The twelfth century in Europe, hailed by historians as a time of intellectual and spiritual vitality, had a dark side. As Robert Chazan points out, the marginalization of minorities emerged during the "twelfth-century renaissance" as part of a growing pattern of persecution, and among those stigmatized the Jews figured prominently.The migration of Jews to northern Europe in the late tenth century led to the development of a new set of Jewish communities. This northern Jewry prospered, only to decline sharply two centuries later. Chazan locates the cause of the decline primarily in the creation of new, negative images of Jews. He shows how these damaging twelfth-century stereotypes developed and goes on to chart the powerful, lasting role of the new anti-Jewish imagery in the historical development of antisemitism.This coupling of the twelfth century's notable intellectual bequests to the growth of Western civilization with its legacy of virulent anti-Jewish motifs offers an important new key to understanding modern antisemitism

A Twelfth-Century Communal History of Spires Jewry

Chazan Robert. A Twelfth-Century Communal History of Spires Jewry. In: Revue des études juives, tome 128, n°2-3, avril-septembre 1969. pp. 253-257

The Persecution of 992

Chazan Robert. The Persecution of 992. In: Revue des études juives, tome 129, n°2-4, avril-décembre 1970. pp. 217-221