A Review on Detection of Traumatic brain Injury using Visual-Contextual model in MRI Images

Recently, there are various computational methods to analyze the traumatic brain injury (TBI) from magnetic resonance imaging (MRI).The detection of brain injury is very difficult task in the medical science. There are various soft techniques for the detection of the patch of brain injury on the basis of MRI image contents. This paper gives brief analysis about the different methods to determine the normal and abnormal tissues of the brain

Numerical Modelling of Flow Over Aerator of Orifice Spillway

Source: ICHE Conference Archive - https://mdi-de.baw.de/icheArchiv

High Density Planting in Mango cv. Alphonso

A trial was conducted to optimize spacing for high density planting in mango cv. Alphonso to obtain higher yield/ unit area at the Agriculture Research Station, Mulde, during 2006-07 to 2008-09 with four close spacings and one normal spacing as control. Highest yield (6.4 MT/ha) was recorded with a spacing of 5 m x 5 m without reduction in fruit size in 10 year old plants compared to the mean yield of 1.12 MT/ha in 10m x 10m normal spacing. High density plantation helped to get significantly higher yield per unit area compared to the normal spacing, without affecting size and quality of mango fruits. The highest cost:benefit ratio (2.33) was recorded in high density plantation of 5m x 5m, with maximum net returns of Rs.1,12,000/- per hectare. The present findings show promise for more yield and returns per unit area during the initial years of mango plantation by adopting 5m x 5m high density planting

The Tertiary sequence of Varkala coastal cliffs, southwestern India: An ideal site for Global Geopark

Varkala, along the southwestern coast of Peninsular India, has a unique place in Indian geology and geomorphology due to the presence of coastal lateritic cliffs, which exposes the entire Mio-Pliocene sequence of Warkalli Formation, and is declared as the type area. Stratigraphically, this formation exposes carbonaceous clay with lenses of lignite and sticks of marcasite, followed by variegated clays and sandstone. The presence of variegated lithounits endows beauty to these cliffs. Varkala cliffs, edging the Arabian Sea, run for a length of 7.5 km. These cliffs, together with confined beaches, made Varkala a popular tourist destination. Several geodiversity spots within the Varkala Cliff geoheritage site make Varkala geologically unique, just like the vestiges of the last separation of Indian subcontinent from the Mascarene Plateau; showcasing lateritization and distribution of beach placers, and jarosite, formed as a diagenetic replacement mineral from marcasite and considered as a Martian analog, are distinctiveness of the cliff. Additionally, Varkala is an internationally acclaimed beach tourist destination. Furthermore, there are several geoheritage sites as well as socio-cultural-historical sites in the hinterland of Varkala Cliff geoheritage site, which are within the proposed Varkala Global Geopark jurisdiction. Thus, this area fulfills all the criteria to be a Global Geopark. The socio-economic-environmental analysis showcases the changes that have occurred in these 3-end members. When the economic sphere was unaffected, the social scenario was slightly affected (25%) whereas the environmental aspect then drastically deteriorated by 75%. But, the SWOT analysis still elects Varkala as a potential Global Geopark. The concept of geopark contributes to at least one of the 17 goals in Agenda 2030 Sustainable Development Goals (SDG) of the United Nations (UN). Consequently, this work also aims at propagating, not only the need for converting the geologically prominent areas to a geopark, but also attaining SDG, whatever is possible through geoparks

Variability Studies in Soybean [Glycine max (L.) Merrill]

   Genetic variability, heritability and genetic advance were studied for thirty genotypes of soybean sown in RBD with three replications and data was analysed for eleven quantitative characters. It was observed that high amount of genetic variability with high heritability was present for most of the yield components studied

The data paper: a mechanism to incentivize data publishing in biodiversity science

<p/> <p>Background</p> <p>Free and open access to primary biodiversity data is essential for informed decision-making to achieve conservation of biodiversity and sustainable development. However, primary biodiversity data are neither easily accessible nor discoverable. Among several impediments, one is a lack of incentives to data publishers for publishing of their data resources. One such mechanism currently lacking is recognition through conventional scholarly publication of enriched metadata, which should ensure rapid discovery of 'fit-for-use' biodiversity data resources.</p> <p>Discussion</p> <p>We review the state of the art of data discovery options and the mechanisms in place for incentivizing data publishers efforts towards easy, efficient and enhanced publishing, dissemination, sharing and re-use of biodiversity data. We propose the establishment of the 'biodiversity data paper' as one possible mechanism to offer scholarly recognition for efforts and investment by data publishers in authoring rich metadata and publishing them as citable academic papers. While detailing the benefits to data publishers, we describe the objectives, work flow and outcomes of the pilot project commissioned by the Global Biodiversity Information Facility in collaboration with scholarly publishers and pioneered by Pensoft Publishers through its journals <it>Zookeys</it>, <it>PhytoKeys</it>, <it>MycoKeys</it>, <it>BioRisk</it>, <it>NeoBiota</it>, <it>Nature Conservation</it> and the forthcoming <it>Biodiversity Data Journal</it>. We then debate further enhancements of the data paper beyond the pilot project and attempt to forecast the future uptake of data papers as an incentivization mechanism by the stakeholder communities.</p> <p>Conclusions</p> <p>We believe that in addition to recognition for those involved in the data publishing enterprise, data papers will also expedite publishing of fit-for-use biodiversity data resources. However, uptake and establishment of the data paper as a potential mechanism of scholarly recognition requires a high degree of commitment and investment by the cross-sectional stakeholder communities.</p

Pharmaceutical standardization and physicochemical characterization of traditional ayurvedic mineral drug red ochre roasted in cow‘s ghee (Shuddha Gairik)

303-316Rasashastra is a pharmaceutics branch of Ayurveda describing scientific methods to convert metals and minerals into bio-compatible formulations used individually or plant admixed to enhance their bioavailability and efficacy. In the present study, red ochre (Gairik) powder was processed in cow‘s ghee by textual method of roasting. The steps of preparation and changes in the properties therein were documented and validated in triplicate batches to develop a monograph. Ayurvedic and basic tests were performed to determine the properties of Shuddha Gairik. The physical characterization included Scanning Electron Microscopy (SEM), X-ray Diffraction (XRD), Fourier Transform Infra-red (FT-IR), Dynamic Light Scattering (DLS) and Thermo-gravimetric Analysis (TGA). Elemental composition was estimated by titration and gravimetric analysis while heavy metal limits were assessed using Inductively Coupled Plasma Optical Emission Spectrophotometry (ICPOES). This study depicted that crude red ochre, containing Kaolinite with high iron percentage, on roasting in cow‘s ghee led to the formation of fatty acids adsorbed red ochre particles. The developed monograph will be a guideline to the Ayurvedic industry for precise formulation of Shuddha Gairik. This will help researchers for better understanding the importance of Ayurvedic methods of pharmaceutical preparations and carry out their mechanistic studies in various diseases

Galantamine Attenuates Type 1 Diabetes and Inhibits Anti-Insulin Antibodies in Non-Obese Diabetic Mice

Type 1 diabetes in mice is characterized by autoimmune destruction of insulin-producing pancreatic beta cells. Disease pathogenesis involves invasion of pancreatic islets by immune cells, including macrophages and T cells, and production of antibodies to self-antigens, including insulin. Activation of the inflammatory reflex, the neural circuit that inhibits inflammation, culminates on cholinergic receptor signals on immune cells to attenuate cytokine release and inhibit B cell antibody production. Here, we show that galantamine, a centrally acting acetylcholinesterase inhibitor and an activator of the inflammatory reflex, attenuates murine experimental type 1 diabetes. Administration of galantamine to animals immunized with keyhole limpet hemocyanin (KLH) significantly suppressed splenocyte release of immunoglobulin G (IgG), interleukin-4 and -6 (IL-4 and IL-6) during KLH-challenge ex vivo. Administration of galantamine beginning at one month of age in non-obese diabetic (NOD) mice significantly delayed the onset of hyperglycemia, attenuated immune cell infiltration in pancreatic islets and decreased anti-insulin antibodies in serum. These observations indicate that galantamine attenuates experimental type 1 diabetes in mice and suggest that activation of the inflammatory reflex should be further studied as a potential therapeutic approach

Synthesis and Pharmacological Evaluation of Pyrazoline and Pyrimidine Analogs of Combretastatin-A4 as Anticancer, Anti-inflammatory and Antioxidant Agents

A library of 3,5-diaryl-1-carbothioamide-pyrazoline (5a–j), N1-phenyl sulfonyl pyrazoline (6a–e) and pyrimidine (7a) analogs of combretastatin-A4 were synthesized and evaluated for their in vitro anticancer, anti-inflammatory and antioxidant activity. Results of in vitro assay against human breast cancer cell line (MCF-7) showed several compounds endowed with significant cytotoxicity compared to the adriamycin, a standard anticancer drug. Among the compounds synthesized, 7a was found to possess significant antiproliferative activity (GI50 < 0.1 µM) against the MCF-7 cell line as good as adriamycin (GI50 < 0.1 µM) whereas, compounds 6c, 5j and 5g also displayed good cytotoxicity (GI50 = 25.3–42.6 µM). Besides this, most active compound 7a was also evaluated against human myeloid leukemia cell line K562 and the remarkable result was obtained with GI50 < 0.1 µM, comparable to that of adriamycin (GI50 < 0.1 µM). In addition, all the synthesized compounds were evaluated for their anti-inflammatory and antioxidant activity. The percent inhibition studies revealed that most of the compounds were found to possess substantial anti-inflammatory and antioxidant activities. This work is licensed under a Creative Commons Attribution 4.0 International License