Comments on the Quark Content of the Scalar Meson f0(1370)f_0(1370)

Based on the measurements of $(D_s^+,D^+)\to f_0(1370)\pi^+$ we determine, in a model independent way, the allowed $s\bar s$ content in the scalar meson $f_0(1370)$. We find that, on the one hand, if this isoscalar resonance is a pure $n\bar n$ state [ $n\bar n\equiv(u\bar u+d\bar d)/\sqrt{2} ]$, a very large $W$-annihilation term will be needed to accommodate $D_s^+\to f_0(1370)\pi^+$. On the other hand, the $s\bar s$ component of $f_0(1370)$ should be small enough to avoid excessive $D_s^+\to f_0(1370)\pi^+$ induced from the external $W$-emission. Measurement of $f_0(1370)$ production in the decay $D_s^+\to K^+K^-\pi^+$ will be useful to test the above picture. For the decay $D^0\to f_0(1370)\bar K^0$ which is kinematically barely or even not allowed, depending on the mass of $f_0(1370)$, we find that the finite width effect of $f_0(1370)$ plays a crucial role on the resonant three-body decay $D^0\to f_0(1370)\bar K^0\to\pi^+\pi^-\bar K^0$.Comment: 12 pages, 2 figure

Final-State Phases in Charmed Meson Two-Body Nonleptonic Decays

Observed decay rates indicate large phase differences among the amplitudes for the charge states in $D \to \bar K \pi$ and $D \to \bar K^* \pi$ but relatively real amplitudes in the charge states for $D \to \bar K \rho$. This feature is traced using an SU(3) flavor analysis to a sign flip in the contribution of one of the amplitudes contributing to the latter processes in comparison with its contribution to the other two sets. This amplitude may be regarded as an effect of rescattering and is found to be of magnitude comparable to others contributing to charmed particle two-body nonleptonic decays.Comment: 19 pages, latex, 4 figures, to be submitted to Phys. Rev.

Two-Body Cabibbo-Suppressed Charmed Meson Decays

Singly-Cabibbo-suppressed decays of charmed particles governed by the quark subprocesses $c \to s u \bar s$ and $c \to d u \bar d$ are analyzed using a flavor-topology approach, based on a previous analysis of the Cabibbo-favored decays governed by $c \to s u \bar d$. Decays to $PP$ and $PV$, where $P$ is a pseudoscalar meson and $V$ is a vector meson, are considered. We include processes in which $\eta$ and $\eta '$ are produced.Comment: 18 pages, latex, 2 figures, to be submitted to Phys. Rev.

Good Quantum Convolutional Error Correction Codes And Their Decoding Algorithm Exist

Quantum convolutional code was introduced recently as an alternative way to protect vital quantum information. To complete the analysis of quantum convolutional code, I report a way to decode certain quantum convolutional codes based on the classical Viterbi decoding algorithm. This decoding algorithm is optimal for a memoryless channel. I also report three simple criteria to test if decoding errors in a quantum convolutional code will terminate after a finite number of decoding steps whenever the Hilbert space dimension of each quantum register is a prime power. Finally, I show that certain quantum convolutional codes are in fact stabilizer codes. And hence, these quantum stabilizer convolutional codes have fault-tolerant implementations.Comment: Minor changes, to appear in PR

Quantum Convolutional Error Correcting Codes

I report two general methods to construct quantum convolutional codes for $N$-state quantum systems. Using these general methods, I construct a quantum convolutional code of rate 1/4, which can correct one quantum error for every eight consecutive quantum registers.Comment: Minor revisions and clarifications. To appear in Phys. Rev.

Hadronic Charmed Meson Decays Involving Tensor Mesons

Charmed meson decays into a pseudoscalar meson P and a tensor meson T are studied. The charm to tensor meson transition form factors are evaluated in the Isgur-Scora-Grinstein-Wise (ISGW) quark model. It is shown that the Cabibbo-allowed decay $D_s^+\to f_2(1270)\pi^+$ is dominated by the W-annihilation contribution and has the largest branching ratio in $D\to TP$ decays. We argue that the Cabibbo-suppressed mode $D^+\to f_2(1270)\pi^+$ should be suppressed by one order of magnitude relative to $D_s^+\to f_2(1270)\pi^+$. When the finite width effect of the tensor resonances is taken into account, the decay rate of $D\to TP$ is generally enhanced by a factor of $2\sim 3$. Except for $D_s^+\to f_2(1270)\pi^+$, the predicted branching ratios of $D\to TP$ decays are in general too small by one to two orders of magnitude compared to experiment. However, it is very unlikely that the $D\to T$ transition form factors can be enhanced by a factor of $3\sim 5$ within the ISGW quark model to account for the discrepancy between theory and experiment. As many of the current data are still preliminary and lack sufficient statistic significance, more accurate measurements are needed to pin down the issue.Comment: 11 page

Flavor SU(3) symmetry and QCD factorization in B→PPB \to PP and PVPV decays

Using flavor SU(3) symmetry, we perform a model-independent analysis of charmless $\bar B_{u,d} (\bar B_s) \to PP, ~PV$ decays. All the relevant topological diagrams, including the presumably subleading diagrams, such as the QCD- and EW-penguin exchange diagrams and flavor-singlet weak annihilation ones, are introduced. Indeed, the QCD-penguin exchange diagram turns out to be important in understanding the data for penguin-dominated decay modes. In this work we make efforts to bridge the (model-independent but less quantitative) topological diagram or flavor SU(3) approach and the (quantitative but somewhat model-dependent) QCD factorization (QCDF) approach in these decays, by explicitly showing how to translate each flavor SU(3) amplitude into the corresponding terms in the QCDF framework. After estimating each flavor SU(3) amplitude numerically using QCDF, we discuss various physical consequences, including SU(3) breaking effects and some useful SU(3) relations among decay amplitudes of $\bar B_s \to PV$ and $\bar B_d \to PV$.Comment: 47 pages, 3 figures, 28 table

Glucocerebrosidase activity, cathepsin D and monomeric α-synuclein interactions in a stem cell derived neuronal model of a PD associated GBA1 mutation.

The presence of GBA1 gene mutations increases risk for Parkinson's disease (PD), but the pathogenic mechanisms of GBA1 associated PD remain unknown. Given that impaired α-synuclein turnover is a hallmark of PD pathogenesis and cathepsin D is a key enzyme involved in α-synuclein degradation in neuronal cells, we have examined the relationship of glucocerebrosidase (GCase), cathepsin D and monomeric α-synuclein in human neural crest stem cell derived dopaminergic neurons. We found that normal activity of GCase is necessary for cathepsin D to perform its function of monomeric α-synuclein removal from neurons. GBA1 mutations lead to a lower level of cathepsin D protein and activity, and higher level of monomeric α-synuclein in neurons. When GBA1 mutant neurons were treated with GCase replacement or chaperone therapy; cathepsin D protein levels and activity were restored, and monomeric α-synuclein decreased. When cathepsin D was inhibited, GCase replacement failed to reduce monomeric α-synuclein levels in GBA1 mutant neurons. These data indicate that GBA1 gene mutations increase monomeric α-synuclein levels via an effect on lysosomal cathepsin D in neurons

Hadronic Charmed Meson Decays Involving Axial Vector Mesons

Cabibbo-allowed charmed meson decays into a pseudoscalar meson and an axial-vector meson are studied. The charm to axial-vector meson transition form factors are evaluated in the Isgur-Scora-Grinstein-Wise quark model. The dipole momentum dependence of the $D\to K$ transition form factor and the presence of a sizable long-distance $W$-exchange are the two key ingredients for understanding the data of $D\to \bar Ka_1$. The $K_{1A}-K_{1B}$ mixing angle of the strange axial-vector mesons is found to be $\approx \pm37^\circ$ or $\pm58^\circ$ from $\tau\to K_1\nu_\tau$ decays. The study of $D\to K_1(1270)\pi, K_1(1400)\pi$ decays excludes the positive mixing-angle solutions. It is pointed out that an observation of the decay $D^0\to K_1^-(1400)\pi^+$ at the level of $5\times 10^{-4}$ will rule out $\theta\approx -37^\circ$ and favor the solution $\theta\approx -58^\circ$. Though the decays $D^0\to \bar K_1^0\pi^0$ are color suppressed, they are comparable to and even larger than the color-allowed counterparts: $\bar K_1^0(1270)\pi^0\sim K_1^-(1270)\pi^+$ and $\bar K_1^0(1400)\pi^0> K_1^-(1400)\pi^+$. The finite width effect of the axial-vector resonance is examined. It becomes important for $a_1(1260)$ in particular when its width is near 600 MeV.Comment: 19 page

In Vivo screening and discovery of novel candidate thalidomide analogs in the zebrafish embryo and chicken embryo model systems

This study was supported by a Wellcome Trust-NIH PhD Studentship to SB, WDF and NV. Grant number 098252/Z/12/Z. SB, CHC and WDF are supported by the Intramural Research Program, NCI, NIH. NHG and WL are supported by the Intramural Research Program, NIA, NIH.Peer reviewedPublisher PD