On The Role Of Harmonia In Plato’s Philosophy

In this dissertation, I investigate Plato’s apparently diverse usages of the notion ‘harmonia’ in order to ascertain a) whether these usages have anything in common and, relatedly, b) whether this notion plays a significant role in Plato’s philosophy. I begin with a survey of pre-Platonic texts before turning to four key Platonic dialogues: the Gorgias, the Phaedo, the Republic, and the Timaeus in order to argue that, even though most contemporary studies of Plato’s thought fail to study this notion in any detail, it nonetheless plays an important role in many of his central doctrines. I contend that harmonia is an intelligible, mathematical structure that operates throughout the microcosm (soul, body, city-state) and macrocosm (the universe) and, in each case, it serves to improve the entities in which it is instantiated. We need harmonia in order to ascend to the study of the Good which, for Plato, is the highest study; harmonia is, then, a crucial means to the most important end

Spectrum of Pediatric Malignancies: An Observational Single Center Study from Western India

Cancer is a leading cause of death for children and adolescent worldwide. The cure rates in low middle-income countries are dismal (20%) in comparison to high income countries (80%). The first move is to assemble precise data on epidemiology of pediatric cancer across the country and its region wide variation. This study attempts to provide spectrum of pediatric malignancies from a tertiary care hospital in the state of Rajasthan, India. A total of 140 cases were studied retrospectively over a period of two years (April 2018-March 2020). Patients, 0-18 years of age that are diagnosed as a case of malignancy were included in this study. The records of these patients were retrieved and analyzed. Patients were stratified in 4 groups; 0-4 years, 5-9 years, 10-14 years and 15-18 years. Most of the patients fell in 15-18 year group (35.7%), followed by 5-9 year group (28.5%). Majority of cases, 67.8% were male. The male to female ratio is 2.1:1. Leukemia (40%) was the most common malignancy followed by lymphoma, retinoblastoma and malignant bone tumors. Acute lymphoblastic leukemia comprises majority (35/56) of leukemia. Retinoblastoma was predominant malignancy among <5-year children. In all other groups, leukemia was predominant. This study gauges the trend of pediatric malignancies at one of the largest tertiary care hospitals in Rajasthan, which is important in the planning and evaluation of health strategies. As we lack a dedicated pediatric cancer registry, such epidemiological studies play a significant part for this small but distinguished group of patients

Gabapentin a pre-emptive analgesic in post-operative pain: a randomised double blind placebo controlled study

Background: Conventional analgesics, used in peri-operative period cause numerous adverse effects and are not free from interactions with co-administered drugs. Gabapentin has been shown to be effective in various types of neuropathic pain. The primary aim of this study was to evaluate gabapentin as a post-operative analgesic. The study also evaluates the analgesic requirement and safety of gabapentin in post-operative period.Methods: Forty patients undergoing elective laparoscopic cholecystectomy were randomized to receive gabapentin or a matching placebo. The patients of group I received gabapentin 600mg orally 2 hrs before surgery and 12hrs after the first dose. The patients in group II received a matching placebo. Patients in both groups received diclofenac sodium 75mg i.m b.i.d for pain. Additional doses were given on demand and recorded.Results: The present study found that gabapentin significantly reduced pain score and analgesic consumption as compared to a placebo for a period of 24 hours.Conclusions: Gabapentin in the doses used was found to be effective in postoperative pain in patients undergoing planned laparoscopic cholecystectomy. It was found to be safe and no serious adverse events were reported

Gabapentin pre-treatment for pressor response to direct laryngoscopy and tracheal intubation: a randomized, double-blind, placebo-controlled study

Background: Laryngoscopy and endotracheal intubation are associated with an increase in blood pressure (BP) and heart rate (HR). The present study was conducted to evaluate the role of gabapentin in attenuation of these hemodynamic changes.Methods: Forty patients undergoing elective laparoscopic cholecystectomy under general anesthesia with standardized premedication and anesthetics were randomized to receive gabapentin or a matching placebo. The patients of Group I received gabapentin 600 mg orally 2 hrs before surgery and patients in Group II received a matching placebo. Patient’s HR, systolic BP (SBP), diastolic BP (DBP), mean BP (MBP), were monitored before and after 1, 2, 5, and 10 mins of endotracheal intubation.Results: Comparison of SBP, DBP, and MBP at 1, 2, 5 and 10 mins after endotracheal intubation showed statistically significant attenuation in the gabapentin group when compared to placebo. Changes in the HR were not significant.Conclusion: Gabapentin 600 mg, given 2 hrs before induction is effective in attenuating the pressor response to laryngoscopy and tracheal intubation

Gabapentin for post-operative nausea and vomiting: a pilot study

Background: Gabapentin has been used in perioperative setting for the management of post-operative pain for surgery performed under general anaesthesia. Post-operative nausea and vomiting (PONV) even with the use of newer agents remains a major problem. The primary aim of this study was to see if gabapentin use decreased PONV.Methods: A total of 40 patients undergoing elective laparoscopic cholecystectomy under general anesthesia with standardized premedication and anesthetics were randomized to receive gabapentin or a matching placebo. The patients in Group I received gabapentin 600 mg orally 2 hrs before surgery and 12 hrs after the first dose. The patients in Group II received a matching placebo orally 2 hrs before surgery and 12hrs after the first dose. Patients in both groups received diclofenac sodium 75 mg i.m b.i.d for pain and ondensetron 4 mg i.v for PONV. Additional doses were given on demand and recorded. The treatment was double blinded.Results: The present study did not find significant reduction in PONV score and antiemetic consumption in gabapentin group when compared to a placebo for a period of 24 hrs.Conclusions: Gabapentin in the doses used was found to ineffective in post-operative nausea and vomiting in patients undergoing planned laparoscopic cholecystectomy with standardized pre-anaesthetic and anaesthetic medication

Medium optimization for the production of lipstatin by Streptomyces toxytricini using full factorial design of experiment

Abstract: Full factorial design of experiment for medium optimization was employed for lipstatin production by Streptomyces toxytricini in shake flask study. The full factorial DOE was very much effective in screening of nutritional parameters within the stipulated time frame in a limited number of experiments. A maximum lipstatin production was achieved 3.290 g/l with the following optimized factors: soya flour 35g/l and soya oil 25g/l. Validation experiments were also carried out to verify the adequacy and the accuracy of the model. The results also give a scope for large scale fermentation of lipstatin production. [Luthra, U., Kumar, H., Kulshreshtha, N., Tripathi, A., Trivedi, A., Khadpekar, S., Chaturvedi, A. and Dubey, R.C. Medium optimization for the production of lipstatin by Streptomyces toxytricini using full factorial design of experiment. Nat Sci 2013;1

On The Role Of Harmonia In Plato’s Philosophy

In this dissertation, I investigate Plato’s apparently diverse usages of the notion ‘harmonia’ in order to ascertain a) whether these usages have anything in common and, relatedly, b) whether this notion plays a significant role in Plato’s philosophy. I begin with a survey of pre-Platonic texts before turning to four key Platonic dialogues: the Gorgias, the Phaedo, the Republic, and the Timaeus in order to argue that, even though most contemporary studies of Plato’s thought fail to study this notion in any detail, it nonetheless plays an important role in many of his central doctrines. I contend that harmonia is an intelligible, mathematical structure that operates throughout the microcosm (soul, body, city-state) and macrocosm (the universe) and, in each case, it serves to improve the entities in which it is instantiated. We need harmonia in order to ascend to the study of the Good which, for Plato, is the highest study; harmonia is, then, a crucial means to the most important end

On the Role of Harmonia in Plato\u27s Philosophy

In this dissertation, I investigate Plato’s apparently diverse usages of the notion ‘harmonia’ in order to ascertain a) whether these usages have anything in common and, relatedly, b) whether this notion plays a significant role in Plato’s philosophy. I begin with a survey of pre-Platonic texts before turning to four key Platonic dialogues: the Gorgias, the Phaedo, the Republic , and the Timaeus in order to argue that, even though most contemporary studies of Plato’s thought fail to study this notion in any detail, it nonetheless plays an important role in many of his central doctrines. I contend that harmonia is an intelligible, mathematical structure that operates throughout the microcosm (soul, body, city-state) and macrocosm (the universe) and, in each case, it serves to improve the entities in which it is instantiated. We need harmonia in order to ascend to the study of the Good which, for Plato, is the highest study; harmonia is, then, a crucial means to the most important end.

Estimation procedures for reliability functions of Kumaraswamy-G Distributions based on Type II Censoring and the sampling scheme of Bartholomew

In this paper, we consider Kumaraswamy-G distributions and derive a Uniformly Minimum Variance Unbiased Estimator (UMVUE) and a Maximum Likelihood Estimator (MLE) of the two measures of reliability, namely R(t) = P(X > t) and P = P(X > Y) under Type II censoring scheme and sampling scheme of Bartholomew (1963). We also develop interval estimates of the reliability measures. A comparative study of the different methods of point estimation has been conducted on the basis of simulation studies. An analysis of a real data set has been presented for illustration purposes