438 research outputs found

    Synthesis of CdS nanoparticles within thermally evaporated aerosol OT thin films

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    In this paper, we discuss the synthesis of cadmium sulfide (CdS) quantum dots within thermally evaporated sodium bis(2-ethylhexyl)sulfosuccinate (AOT) thin films. This procedure uses electrostatic interactions to entrap positively charged cadmium ions into thin films of the anionic surfactant AOT by a simple immersion of the film in electrolyte solution. Thereafter, the composite film is treated with H2S gas/Na2S solution resulting in the in-situ formation of CdS nanoparticles in the quantum size regime. It is believed that the ability of AOT molecules in the thermally evaporated thin films to form reverse micelles is responsible for the CdS nanoparticle size control observed. Investigation of the entrapment of cadmium ions in the AOT film and subsequent quantum dot synthesis was carried out by quartz crystal microgravimetry (QCM), UV-Vis spectroscopy, Fourier transform infrared (FTIR) spectroscopy and transmission electron microscopy (TEM) measurements

    Anti-Inflammatory Potential of Ethanolic Leaf Extract of Eupatorium adenophorum Spreng. Through Alteration in Production of TNF-α, ROS and Expression of Certain Genes

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    Search for a novel anti-inflammatory agent from a herbal source, such as Eupatorium adenophorum Spreng., a plant from the Eastern Himalayas, is of prime interest in the present investigation. Inflammation causes tissue destruction and development of diseases such as asthma, rheumatoid arthritis, and so forth. The ethanolic leaf extract of E. adenophorum (EEA) was administered intravenously and in other cases topically at the site of delayed type hypersensitivity (DTH) reaction in mouse foot paw induced with dinitrofluorobenzene. EEA can effectively inhibit DTH reaction and bring back normalcy to the paw much earlier than the controls. Efficacy of EEA on regulatory mechanisms for inflammation has also been considered. Intravenous administration of EEA increased the number of CD4+ T cells in spleen and tumor necrosis factor (TNF)-α in serum of DTH mice. Initially it was difficult to reconcile with the anti-inflammatory role of EEA and simultaneous induction of TNF-α, an established pro-inflammatory cytokine. EEA induces higher expression of TNF-α gene and amount of the cytokine in serum. We discussed the other role of TNF-α, its involvement in repairing tissue damage incurred in course of inflammatory reaction. EEA also induces TGF-β encoding a cytokine involved in tissue repair mechanism. EEA inhibits expression of another pro-inflammatory cytokine gene IL-1β and downregulates cycloxygenase 2 (COX2) gene responsible for metabolism of inflammatory mediators like prostaglandins. Furthermore, anti-inflammatory role of EEA is also revealed through its inhibition of hydroxyl radical generation. Notably EEA does not necessarily affect the expression of other inflammation-related genes such as IL-6, IL-10 and IKK. The present study reports and analyzes for the first time the anti-inflammatory property of the leaf extract of E. adenophorum

    Recent Trends in Big Data Analytics and Role in Business Decision Making

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    In this information overload era, we can see that a large amount of data has been available for everyone, and it helps business organizations to take strategic decisions. The rapid increase of internet and digital marketing has made increased in demand for data. And we can see that the volume of the data is very high which can't be handled using traditional systems. Data has become more valuable nowadays for organizations because of the valuable insights in the data. Present we can see that every day millions of data was generated through our daily transactions to customer interactions and various social media networks. As we can that data is of various types like structured, and unstructured data, the data need to be cleaned and it should be converted into meaningful information for the organizations. In this paper, we are focusing on how big data will show an impact on business decision-making, and how big data will play a crucial role in the decision-making process

    A Comprehensive Solution to Automated Inspection Device Selection Problems using ELECTRE Methods

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    Selection of an automated inspection device for an explicit industrial application is one of the most challenging problems in the current manufacturing environment. It has become more and more complicated due to increasing complexity, advanced features and facilities that are endlessly being integrated into the devices by different manufacturers. Selection of inspection devices plays a significant role in a manufacturing system for cost effectiveness and improved productivity. This paper focuses on the application of a very popular Multi-Criteria Decision-Making (MCDM) tool, i.e. ELimination and Et Choice Translating REality (ELECTRE) for solving an automated inspection device selection problem in a discrete manufacturing environment. Using a sample case study from the published literature, this paper attempts to show how different variants of the ELECTRE method, namely ELECTRE II, IS, III, IV and TRI can be suitably applied in choosing the most efficient alternative that accounts for both the decision maker’s intervention and other technical elements. Using different ELECTRE methods, a list of all the possible choices from the best to the worst suitable devices is obtained while taking into account different selection attributes. The ranking performance of these methods is also compared with that of the past researchers

    Analysis of the universal immunization programme and introduction of a rotavirus vaccine in India with IndiaSim

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    India has the highest under-five death toll globally, approximately 20% of which is attributed to vaccine-preventable diseases. India's Universal Immunization Programme (UIP) is working both to increase immunization coverage and to introduce new vaccines. Here, we analyze the disease and financial burden alleviated across India's population (by wealth quintile, rural or urban area, and state) through increasing vaccination rates and introducing a rotavirus vaccine. We use IndiaSim, a simulated agent-based model (ABM) of the Indian population (including socio-economic characteristics and immunization status) and the health system to model three interventions. In the first intervention, a rotavirus vaccine is introduced at the current DPT3 immunization coverage level in India. In the second intervention, coverage of three doses of rotavirus and DPT and one dose of the measles vaccine are increased to 90% randomly across the population. In the third, we evaluate an increase in immunization coverage to 90% through targeted increases in rural and urban regions (across all states) that are below that level at baseline. For each intervention, we evaluate the disease and financial burden alleviated, costs incurred, and the cost per disability-adjusted life-year (DALY) averted. Baseline immunization coverage is low and has a large variance across population segments and regions. Targeting specific regions can approximately equate the rural and urban immunization rates. Introducing a rotavirus vaccine at the current DPT3 level (intervention one) averts 34.7 (95% uncertainty range [UR], 31.7–37.7) deaths and 215,569(95215,569 (95% UR, 207,846–223,292)outofpocket(OOP)expenditureper100,000underfivechildren.Increasingallimmunizationratesto90223,292) out-of-pocket (OOP) expenditure per 100,000 under-five children. Increasing all immunization rates to 90% (intervention two) averts an additional 22.1 (95% UR, 18.6–25.7) deaths and 45,914 (95% UR, 37,90937,909–53,920) OOP expenditure. Scaling up immunization by targeting regions with low coverage (intervention three) averts a slightly higher number of deaths and OOP expenditure. The reduced burden of rotavirus diarrhea is the primary driver of the estimated health and economic benefits in all intervention scenarios. All three interventions are cost saving. Improving immunization coverage and the introduction of a rotavirus vaccine significantly alleviates disease and financial burden in Indian households. Population subgroups or regions with low existing immunization coverage benefit the most from the intervention. Increasing coverage by targeting those subgroups alleviates the burden more than simply increasing coverage in the population at large
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