Degeneracy resolution capabilities of NOν\nuA and DUNE in the presence of light sterile neutrino

We investigate the implications of a sterile neutrino on the physics potential of the proposed experiment DUNE and future runs of NO$\nu$A using latest NO$\nu$A results. Using combined analysis of the disappearance and appearance data, NO$\nu$A reported preferred solutions at normal hierarchy (NH) with two degenerate best-fit points one in the lower octant (LO) and $\delta_{13}$ = 1.48$\pi$ and other in higher octant (HO) and $\delta_{13}$ = 0.74$\pi$. Another solution of inverted hierarchy (IH) which is 0.46$\sigma$ away from best fit was also reported. We discuss chances of resolving these degeneracies in the presence of sterile neutrino.Comment: 16 pages 5 figures,Updated for the journa

Measurement of the νe -Nucleus Charged-Current Double-Differential Cross Section at «eν »=2.4 GeV Using NOvA

The inclusive electron neutrino charged-current cross section is measured in the NOvA near detector using 8.02×1020 protons-on-target in the NuMI beam. The sample of GeV electron neutrino interactions is the largest analyzed to date and is limited by ≃17% systematic rather than the ≃7.4% statistical uncertainties. The double-differential cross section in final-state electron energy and angle is presented for the first time, together with the single-differential dependence on Q2 (squared four-momentum transfer) and energy, in the range 1 GeV≤Eν<6 GeV. Detailed comparisons are made to the predictions of the GENIE, GiBUU, NEUT, and NuWro neutrino event generators. The data do not strongly favor a model over the others consistently across all three cross sections measured, though some models have especially good or poor agreement in the single differential cross section vs Q2

Search for CP-violating Neutrino Non-Standard Interactions with the NOvA Experiment

This Letter reports a search for charge-parity (CP) symmetry violating non-standard interactions (NSI) of neutrinos with matter using the NOvA Experiment, and examines their effects on the determination of the standard oscillation parameters. Data from $\nu_{\mu}(\bar{\nu}_{\mu})\rightarrow\nu_{\mu}(\bar{\nu}_{\mu})$ and $\nu_{\mu}(\bar{\nu}_{\mu})\rightarrow\nu_{e}(\bar{\nu}_{e})$ oscillation channels are used to measure the effect of the NSI parameters $\varepsilon_{e\mu}$ and $\varepsilon_{e\tau}$. With 90% C.L. the magnitudes of the NSI couplings are constrained to be $|\varepsilon_{e\mu}| \, \lesssim 0.3$ and $|\varepsilon_{e\tau}| \, \lesssim 0.4$. A degeneracy at $|\varepsilon_{e\tau}| \, \approx 1.8$ is reported, and we observe that the presence of NSI limits sensitivity to the standard CP phase $\delta_{\tiny\text{CP}}$

Measurement of the νe−\nu_e-Nucleus Charged-Current Double-Differential Cross Section at <Eν>=\left< E_{\nu} \right> = 2.4 GeV using NOvA

The inclusive electron neutrino charged-current cross section is measured in the NOvA near detector using $8.02\times10^{20}$ protons-on-target (POT) in the NuMI beam. The sample of GeV electron neutrino interactions is the largest analyzed to date and is limited by $\simeq$ 17\% systematic rather than the $\simeq$ 7.4\% statistical uncertainties. The double-differential cross section in final-state electron energy and angle is presented for the first time, together with the single-differential dependence on $Q^{2}$ (squared four-momentum transfer) and energy, in the range 1 GeV $\leq E_{\nu} <$6 GeV. Detailed comparisons are made to the predictions of the GENIE, GiBUU, NEUT, and NuWro neutrino event generators. The data do not strongly favor a model over the others consistently across all three cross sections measured, though some models have especially good or poor agreement in the single differential cross section vs. $Q^{2}$

Complex Networks and SOA: Mathematical Modelling of Granularity Based Web Service Compositions

Service Oriented Architecture (SOA) can be defined as a way of defining and implementing enterprise applications that deals with the intercommunication of loosely coupled, coarse grained (business level), reusable artifacts (services). In this paper, we attempt to mathematically model the preliminary steps in the larger problem of providing an optimal architecture. The problem is treated as a complex network, particularly a process-task-network. We employ statistical and graph-theoretic methods namely, Jaccard\u27s distance analysis, Multiple Correspondence method and the Minimum Spanning Tree method, to find appropriate clusters. These methods are used to cluster tasks across business processes to propose services. Additional properties and features of these clusters are discussed. We propose a leverage factor which demonstrates the importance of a task within the service and its impact on service composition

Zebrafish Sensitivity to Botulinum Neurotoxins

Botulinum neurotoxins (BoNT) are the most potent known toxins. The mouse LD50 assay is the gold standard for testing BoNT potency, but is not sensitive enough to detect the extremely low levels of neurotoxin that may be present in the serum of sensitive animal species that are showing the effects of BoNT toxicity, such as channel catfish affected by visceral toxicosis of catfish. Since zebrafish are an important animal model for diverse biomedical and basic research, they are readily available and have defined genetic lines that facilitate reproducibility. This makes them attractive for use as an alternative bioassay organism. The utility of zebrafish as a bioassay model organism for BoNT was investigated. The 96 h median immobilizing doses of BoNT/A, BoNT/C, BoNT/E, and BoNT/F for adult male Tübingen strain zebrafish (0.32 g mean weight) at 25 °C were 16.31, 124.6, 4.7, and 0.61 picograms (pg)/fish, respectively. These findings support the use of the zebrafish-based bioassays for evaluating the presence of BoNT/A, BoNT/E, and BoNT/F. Evaluating the basis of the relatively high resistance of zebrafish to BoNT/C and the extreme sensitivity to BoNT/F may reveal unique functional patterns to the action of these neurotoxins

Hydrodeoxygenation activity of W modified Ni/H-ZSM-5 catalyst for single step conversion of levulinic acid to pentanoic acid: An insight on the reaction mechanism and structure activity relationship

Direct conversion of levulinic acid (LA) to pentanoic acid (PA) was achieved over the W modified Ni supported on SiO2, Al2O3 and H-ZSM-5 catalysts at 270 degrees C and ambient H-2 pressure in a continuous flow fixed-bed reactor. The interaction between Ni and W was the key which is rationalized by XRD, XPS, TGA-TPD of NH3, DRIFTS, TEM, CO-pulse chemisorption and H-2-TPR analyses. PA rate of similar to 1.24 mu mol s(-1) g(eat)(-1) (with highest LA conversion similar to 40% and selectivity similar to 65% after 6 h of continuous operation) achieved over W modified Ni/H-ZSM-5 catalyst compared to others. The better PA rate on Ni-W/H-ZSM-5 catalyst was manifested by the presence of not only strong acid sites and also due to a higher number surface ionic Ni species which were responsible for the ring opening of gamma-valerolactone (GVL) and the beta-proton abstraction that occurred on basic sites. On the contrary, Ni-W/SiO2, Ni-W/Al2O3 and Ni/H-ZSM-5 were found to be less selective towards PA and more selective towards GVL, exemplifying the role of support and W for the PA selectivity. The surface active sites for the PA formation are illustrated by using probes such as pyridine (strong base) and/or acetone (mild base) and formic acid adsorbed DRIFT spectroscopy. Based on the product distribution, a plausible surface mechanism was also elucidated and discussed

Novel Etoposide Analogue Modulates Expression of Angiogenesis Associated microRNAs and Regulates Cell Proliferation by Targeting STAT3 in Breast Cancer.

Tumor microenvironment play role in angiogenesis and carcinogenesis. Etoposide, a known topoisomerase II inhibitor induces DNA damage resulting in cell cycle arrest. We developed a novel Etoposide analogue, Quinazolino-4β-amidopodophyllotoxin (C-10) that show better efficacy in regulating cell proliferation and angiogenesis. We evaluated its role on expression of microRNAs-15, 16, 17 and 221 and its targets Bcl-2, STAT3 and VEGF that dictate cell proliferation and angiogenesis. Docking studies clearly demonstrated the binding of Etoposide and C-10 to STAT3. We conclude that combination of Etoposide or C-10 with miR-15, 16, 17 and 221 as a new approach to induce apoptosis and control angiogenesis in breast cancer